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NOX4: NADPH oxidase 4

1 protein, 12 patents, 1 drug, 6 trials, 3,393 NIH grants and 8,576 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNOX4HGNC
NameNADPH oxidase 4HGNC
NCBI Gene ID50507NCBI Gene
HGNC IDHGNC:7891HGNC
EnsemblENSG00000086991NCBI Gene
AliasesKOX, KOX-1, RENOXNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9NPH5NADPH oxidase 45780Ensembl, GeneID, HGNCUniProt

Patents 12

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455008Q9NPH5Espacenet
KR 1020250158875 A2025-11-072Q9NPH5Espacenet
EP 4641201 A22025-10-291760Q9NPH5Espacenet
JP 2025529142 A2025-09-042868Q9NPH5Espacenet
US 12371689 B22025-07-292868Q9NPH5Espacenet
JP 2025517969 A2025-06-121760Q9NPH5Espacenet
US 11446398 B22022-09-2055290Q9NPH5Espacenet
KR 1020220052829 A2022-04-282Q9NPH5Espacenet
JP 2022524081 A2022-04-27158261Q9NPH5Espacenet
JP 2019054813 A2019-04-11235443Q9NPH5Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
SETANAXIBCHEMBL4303187NADPH oxidase 4 inhibitorINHIBITORChEMBL

Trials 6

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06274489SETANAXIBPHASE1/PHASE2ClinicalTrials.gov
NCT05323656SETANAXIBPHASE22025-05-09ClinicalTrials.gov
NCT05014672SETANAXIBPHASE22025-04-24ClinicalTrials.gov
NCT03865927SETANAXIBPHASE2ClinicalTrials.gov
NCT03226067SETANAXIBPHASE22022-03-31ClinicalTrials.gov
NCT02010242SETANAXIBPHASE22025-02-28ClinicalTrials.gov

NIH grants 3393

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL091469Cysteine oxidation in the heart172,025NIH's project files
ZIABC010677NADPH Oxidases as Novel Targets for Cancer Therapy112,025NIH's project files
I01BX003056Sirtuins in Lung Aging and Fibrosis102,025NIH's project files
P30CA016672Cancer Center Support Grant92,025NIH's project files
P30CA086862Cancer Center Support Grant82,025NIH's project files
P30ES005605Environmental Health Sciences Research Center82,025NIH's project files
R01EY015130Mechanisms of Angiogenesis in ROP82,025NIH's project files
R01EY017011Endothelial Transmigration in Neovascular Age-related Macular Degeneration82,025NIH's project files
R01HL125926Galectin-3: A mediator of vascular remodeling in pulmonary arterial hypertension82,025NIH's project files
P30CA054174Mays Cancer Center at UT Health SA72,025NIH's project files

Papers 8576

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822124PubTator, text miningPubMed
42818031PubTator, text miningPubMed
42807617PubTator, text miningPubMed
42794778PubTator, text miningPubMed
42792154PubTator, text miningPubMed
42756429PubTator, text miningPubMed
42750707PubTator, text miningPubMed
42741546PubTator, text miningPubMed
42704499PubTator, text miningPubMed
42700514PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license