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PAH: phenylalanine hydroxylase

1 protein, 132 patents, 2 drugs, 66 trials, 4,362 NIH grants and 11,351 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPAHHGNC
Namephenylalanine hydroxylaseHGNC
NCBI Gene ID5053NCBI Gene
HGNC IDHGNC:8582HGNC
EnsemblENSG00000171759NCBI Gene
AliasesPH, PKU, PKU1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00439Phenylalanine-4-hydroxylase45220Ensembl, GeneID, HGNCUniProt

Patents 132

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026193218 A12026-09-17365P00439Espacenet
JP 2026126190 A2026-08-041P00439Espacenet
EP 4777618 A12026-07-22647P00439Espacenet
JP 2026120675 A2026-07-22701P00439Espacenet
JP 2026067851 A2026-04-2178P00439Espacenet
US 12599679 B22026-04-14207P00439Espacenet
WO 2025250751 A12025-12-044034P00439Espacenet
EP 4650780 A22025-11-1916539P00439Espacenet
JP 2025169942 A2025-11-141197P00439Espacenet
JP 2025537178 A2025-11-14207P00439Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
SAPROPTERINCHEMBL1201774Phenylalanine-4-hydroxylase activatorACTIVATORChEMBL
SAPROPTERIN DIHYDROCHLORIDECHEMBL1201775Phenylalanine-4-hydroxylase activatorACTIVATORChEMBL

Trials 66

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07574034SAPROPTERINClinicalTrials.gov
NCT06396637SAPROPTERIN DIHYDROCHLORIDEPHASE2ClinicalTrials.gov
NCT05299203SAPROPTERINPHASE1ClinicalTrials.gov
NCT05138887SAPROPTERINPHASE2ClinicalTrials.gov
NCT05114226SAPROPTERINPHASE1ClinicalTrials.gov
NCT04800692SAPROPTERINPHASE1ClinicalTrials.gov
NCT04054973SAPROPTERIN DIHYDROCHLORIDEPHASE2ClinicalTrials.gov
NCT04014712SAPROPTERINPHASE1ClinicalTrials.gov
NCT03864029SAPROPTERIN DIHYDROCHLORIDEClinicalTrials.gov
NCT03820804SAPROPTERIN DIHYDROCHLORIDEClinicalTrials.gov

NIH grants 4362

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1192,025NIH's project files
P30CA008748Cancer Center Support Grant232,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)192,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase122,025NIH's project files
P42ES016465Center for the Science, Technology, and Emerging Health Risks of PAHs122,025NIH's project files
U24CA076518A Data Resource for Blood and Marrow Transplants and Adoptive Cellular Therapy Research112,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award112,025NIH's project files
ZIABC007365Regulation of ADP-ribosylation factor112,025NIH's project files
P30ES009089Center for Environmental Health in Northern Manhattan102,025NIH's project files
P30CA016058Cancer Center Support Grant92,025NIH's project files

Papers 11351

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826228PubTator, text miningPubMed
42812630PubTator, text miningPubMed
42794727PubTator, text miningPubMed
42774687PubTator, text miningPubMed
42746482PubTator, text miningPubMed
42742788PubTator, text miningPubMed
42736418PubTator, text miningPubMed
42732828PubTator, text miningPubMed
42688806PubTator, text miningPubMed
42664530PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license