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SERPINE1: serpin family E member 1

1 protein, 196 patents, 1 drug, 1 trial, 10,924 NIH grants and 32,564 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSERPINE1HGNC
Nameserpin family E member 1HGNC
NCBI Gene ID5054NCBI Gene
HGNC IDHGNC:8583HGNC
EnsemblENSG00000106366NCBI Gene
AliasesPAI, PAI-1, PAI1, PLANH1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P05121Plasminogen activator inhibitor 140229Ensembl, GeneID, HGNCUniProt

Patents 196

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11238P05121Espacenet
JP 2026016529 A2026-02-032P05121Espacenet
WO 2025257350 A12025-12-18250P05121Espacenet
EP 4650780 A22025-11-19584P05121Espacenet
JP 2025147176 A2025-10-0612084P05121Espacenet
JP 2025529142 A2025-09-047687P05121Espacenet
US 12371689 B22025-07-297687P05121Espacenet
JP 2025517970 A2025-06-12584P05121Espacenet
JP 2025028160 A2025-02-2812084P05121Espacenet
JP 2025013347 A2025-01-24238P05121Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALEPLASININCHEMBL325424Plasminogen activator inhibitor-1 inhibitorINHIBITORChEMBL

Trials 1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT00739037ALEPLASININPHASE1ClinicalTrials.gov

NIH grants 10924

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant782,025NIH's project files
R01HL055374Unraveling the role of tPA in the neurovascular unit462,025NIH's project files
P30CA008748Cancer Center Support Grant442,025NIH's project files
T32GM008315Mechanisms of Trauma-Induced Coagulopathy412,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award262,025NIH's project files
P30CA068485Cancer Center Support Grant232,025NIH's project files
R37AG013925Effect of Aging on Preadipocyte Differentiation212,025NIH's project files
P30DK036836Diabetes Research Center202,025NIH's project files
P30DK063491Diabetes Research Center (DRC)202,025NIH's project files
T32ES011564UOFL ENVIRONMENTAL HEALTH SCIENCES TRAINING PROGRAM192,025NIH's project files

Papers 32564

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826913PubTator, text miningPubMed
42820896PubTator, text miningPubMed
42811984PubTator, text miningPubMed
42809927PubTator, text miningPubMed
42804094PubTator, text miningPubMed
42793067PubTator, text miningPubMed
42787653PubTator, text miningPubMed
42780071PubTator, text miningPubMed
42778910PubTator, text miningPubMed
42769819PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license