ConductScience.org, home

Gene · 5055

SERPINB2: serpin family B member 2

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. SERPINB2: serpin family B member 2. Genes, record 5055. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5055

On this page

Gene

Symbol
SERPINB2
HGNC
Name
serpin family B member 2
HGNC
NCBI Gene ID
5055
NCBI Gene
HGNC ID
HGNC:8584
HGNC
Ensembl
ENSG00000197632
NCBI Gene
Aliases
HsT1201, PAI, PAI-2, PAI2, PLANH2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P05120Plasminogen activator inhibitor 24154Ensembl, GeneID, HGNC

Source UniProt

Patents145

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11239P05120Espacenet
EP 4650780 A22025-11-193944P05120Espacenet
EP 4641201 A22025-10-293521P05120Espacenet
JP 2025147176 A2025-10-0612078P05120Espacenet
JP 2025147176 A2025-10-0612079P05120Espacenet
JP 2025529142 A2025-09-047684P05120Espacenet
US 12371689 B22025-07-297684P05120Espacenet
JP 2025517969 A2025-06-123521P05120Espacenet
JP 2025517970 A2025-06-123944P05120Espacenet
JP 2025028160 A2025-02-2812078P05120Espacenet

1 to 10 of 145

See all 145 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,602

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSERPINB2 papersNewest fiscal year
P51OD011092Support for National Primate Research Center82025
P30CA016672Cancer Center Support Grant72025
P30CA134274UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT72025
R01HL080414Phenotypic and biological features of mucus plugs in asthma52025
U19AI077439Immune-driven Airway Epithelial Dysfunction in Muco-obstructive Asthma52025
P30CA010815Consolidated Basic Cancer Research Program42025
P30ES006694Southwest Environmental Health Sciences Center42025
R37AG013925Effect of Aging on Preadipocyte Differentiation42025
U19AI070235Epithelial Genes in Allergic Inflammation42025
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition42025

1 to 10 of 1,602Source NIH's project files

See all 1,602 nih grants

Papers3,233

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A serpin-myeloid axis in pancreatic cancer heterogeneity and immune evasion.Nature202642717081PubTator, text miningPubMed
Combining co-expression analysis and machine learning to explore the diagnostic value of complement and coagulation cascade-related genes in asthma and the functional role of SERPINB2.Brief Funct Genomics202642647769PubTator, text miningPubMed
Allicin Attenuates Silica-Induced Pulmonary Fibrosis by Targeting the Serpinb2/NF-κB Pathway.J Biochem Mol Toxicol202642438949PubTator, text miningPubMed
Inhibition of inflammation and senescence with azole compound C7 enables expansion of hematopoietic stem and progenitor cells.Stem Cells Transl Med202642387854PubTator, text miningPubMed
Increased induced sputum ITGB5 expression was correlated with airway inflammation and lung function in asthma.J Asthma202642370849PubTator, text miningPubMed
Transcriptomic Profile of Genes Regulating Cellular Response to Extra- and Intracellular Stimuli in Porcine Ovarian Granulosa Cells During In Vitro Cultivation.Int J Mol Sci202642353161PubTator, text miningPubMed
Epithelial SERPINB2 Overexpression Contributes to Impaired Fibrinolysis in Chronic Rhinosinusitis With Nasal Polyps via tPA Downregulation.Front Biosci (Landmark Ed)202642216541PubTator, text miningPubMed
PTSD and complex PTSD differ significantly in plasma levels of IL2 and MMP9: patterns associated with traumatic brain injury.Naunyn Schmiedebergs Arch Pharmacol202642012659PubTator, text miningPubMed
Author Correction: Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation.Nat Commun202641997981PubTator, text miningPubMed
Tumor-Specific Pro-Thrombotic Gene Expression in Head and Neck Squamous Cell Carcinoma: A Multi-Cohort Transcriptomic Analysis.Cancers (Basel)202641976278PubTator, text miningPubMed

1 to 10 of 3,233

See all 3,233 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5055

GET https://conductscience.org/api/genes/v1/5055/patents?page=2