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PAK1: p21 (RAC1) activated kinase 1

1 protein, 35 patents, 0 drugs, 0 trials, 3,717 NIH grants and 5,831 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPAK1HGNC
Namep21 (RAC1) activated kinase 1HGNC
NCBI Gene ID5058NCBI Gene
HGNC IDHGNC:8590HGNC
EnsemblENSG00000149269NCBI Gene
AliasesIDDMSSD, PAKalpha, alpha-PAK, p65-PAKNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q13153Serine/threonine-protein kinase PAK 154541Ensembl, GeneID, HGNCUniProt

Patents 35

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026000906 A2026-01-0678Q13153Espacenet
JP 2024123008 A2024-09-107497Q13153Espacenet
US 11892452 B22024-02-0669Q13153Espacenet
US 11892452 B22024-02-0690Q13153Espacenet
JP 2023521339 A2023-05-2478Q13153Espacenet
US 11446398 B22022-09-2060780Q13153Espacenet
JP 2022524081 A2022-04-27163751Q13153Espacenet
WO 2021204910 A12021-10-1478Q13153Espacenet
US 11078247 B22021-08-038092Q13153Espacenet
US 11065251 B22021-07-203Q13153Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3717

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant422,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase402,025NIH's project files
P30CA008748Cancer Center Support Grant302,025NIH's project files
P30CA068485Cancer Center Support Grant112,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant112,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant102,025NIH's project files
P30CA118100University of New Mexico Cancer Center Support Grant102,025NIH's project files
P40OD010440Caenorhabditis Genetics Center92,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program82,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant82,025NIH's project files

Papers 5831

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42800740PubTator, text miningPubMed
42800115PubTator, text miningPubMed
42733189PubTator, text miningPubMed
42671911PubTator, text miningPubMed
42641889PubTator, text miningPubMed
42596835PubTator, text miningPubMed
42529685PubTator, text miningPubMed
42519490PubTator, text miningPubMed
42432304PubTator, text miningPubMed
42418247PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license