ConductScience.org, home

Library / Genes

IL22: interleukin 22

1 protein, 527 patents, 1 drug, 3 trials, 6,907 NIH grants and 17,975 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIL22HGNC
Nameinterleukin 22HGNC
NCBI Gene ID50616NCBI Gene
HGNC IDHGNC:14900HGNC
EnsemblENSG00000127318NCBI Gene
AliasesIL-21, IL-22, IL-D110, IL-TIF, ILTIF, MGC79382, MGC79384, TIFIL-23, TIFa, zcyto18NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9GZX6Interleukin-221796Ensembl, GeneID, HGNCUniProt

Patents 527

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4805380 A12026-09-167Q9GZX6Espacenet
JP 2026102603 A2026-06-231Q9GZX6Espacenet
EP 4705273 A22026-03-11554Q9GZX6Espacenet
JP 2026505362 A2026-02-1344Q9GZX6Espacenet
EP 4661884 A22025-12-1744Q9GZX6Espacenet
EP 4650780 A22025-11-195809Q9GZX6Espacenet
US 12473363 B22025-11-18917Q9GZX6Espacenet
JP 2025169256 A2025-11-1210Q9GZX6Espacenet
EP 4641203 A22025-10-29179Q9GZX6Espacenet
JP 2025147176 A2025-10-067010Q9GZX6Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
FEZAKINUMABCHEMBL1743017Interleukin-22 inhibitorINHIBITORChEMBL

Trials 3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01941537FEZAKINUMABPHASE22019-05-07ClinicalTrials.gov
NCT00883896FEZAKINUMABPHASE22022-10-21ClinicalTrials.gov
NCT00563524FEZAKINUMABPHASE12024-08-23ClinicalTrials.gov

NIH grants 6907

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant512,025NIH's project files
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success402,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital282,025NIH's project files
ZIAAR041159Cytokine Signaling, Immunoregulation and Autoimmune and Immunodeficiency Diseases282,025NIH's project files
ZIAAI000647Genes And Gene Products As Immunoadjuvants242,025NIH's project files
P51OD011104Tulane National Primate Research Center232,025NIH's project files
U01AI095608Regulation of mucosal immunity by neuronal pathways222,025NIH's project files
P51OD011132Emory National Primate Research Center212,025NIH's project files
ZIAAI000646Transgenic Animal Models Of Human Immune Defects212,025NIH's project files
ZIAAI001065India International Center for Excellence in Research212,025NIH's project files

Papers 17975

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42816751PubTator, text miningPubMed
42813198PubTator, text miningPubMed
42812331PubTator, text miningPubMed
42811603PubTator, text miningPubMed
42810772PubTator, text miningPubMed
42810144PubTator, text miningPubMed
42809927PubTator, text miningPubMed
42805450PubTator, text miningPubMed
42802957PubTator, text miningPubMed
42797040PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license