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Gene · 5062

PAK2: p21 (RAC1) activated kinase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PAK2: p21 (RAC1) activated kinase 2. Genes, record 5062. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5062

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Gene

Symbol
PAK2
HGNC
Name
p21 (RAC1) activated kinase 2
HGNC
NCBI Gene ID
5062
NCBI Gene
HGNC ID
HGNC:8591
HGNC
Ensembl
ENSG00000180370
NCBI Gene
Aliases
KNO2, PAK65, PAKgamma
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13177Serine/threonine-protein kinase PAK 25245Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456838Q13177Espacenet
EP 4650780 A22025-11-194940Q13177Espacenet
JP 2025517970 A2025-06-124940Q13177Espacenet
US 11708396 B22023-07-251831Q13177Espacenet
US 11685954 B22023-06-2746Q13177Espacenet
US 11685954 B22023-06-2747Q13177Espacenet
US 11685954 B22023-06-2748Q13177Espacenet
US 11685954 B22023-06-2750Q13177Espacenet
US 11446398 B22022-09-2060791Q13177Espacenet
JP 2022524081 A2022-04-27163762Q13177Espacenet

1 to 10 of 27

See all 27 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,718

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePAK2 papersNewest fiscal year
P30CA006927Comprehensive Cancer Center Program at Fox Chase232025
P30CA008748Cancer Center Support Grant92025
P30CA016672Cancer Center Support Grant92025
P30CA076292Moffitt Cancer Center Support Grant62025
P30CA016058Cancer Center Support Grant42025
P30CA016086Cancer Center Support Grant42025
P30CA030199Cancer Center Support Grant (CCSG)42025
P30CA086862Cancer Center Support Grant42025
R01GM102262LIM domain kinases: regulation and substrate recognition42025
R01MH071316Rac-GEF signaling in dendritic spines42025

1 to 10 of 1,718Source NIH's project files

See all 1,718 nih grants

Papers2,274

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
DISC1 Orchestrates Mitochondrial Calcium Overload in Diabetic Encephalopathy Through a Dual Nucleocytoplasmic Mechanism.Biomolecules202642793198PubTator, text miningPubMed
Phosphorylation Protects Oncogenic RAS from LZTR1-Mediated Degradation.Blood Cancer Discov202642671911PubTator, text miningPubMed
Identification of a nuclear transcriptional module associated with ERα and E2F/FOXM1 signaling across PAM50 breast cancer subtypes.Front Oncol202642620280PubTator, text miningPubMed
Cellular Logistics and Synaptic Vesicle Vulnerability in Major Depressive Disorder and Amyotrophic Lateral Sclerosis Comorbidity: Insights From Nicotinamide Mononucleotide Rescue and Transcriptome-Wide Association Study Integration.
Cureus202642529685PubTator, text miningPubMed
Deciphering Site-Specific Regulatory Networks of the Kinesin Protein KIF21A Through Integrative Phosphoproteomic Analysis.Int J Mol Sci202642511730PubTator, text miningPubMed
Identification of DNA sequence variants in the Vasculo-Behcet disease patient using whole exome sequencing: a pilot study from Pakistan.Sci Rep202642386946PubTator, text miningPubMed
Phosphorylated HAND1 contributes to trophoblast cell migration during placentation by activating the Vav2-Rac1-PAK signaling.Eur J Pharmacol202642361881PubTator, text miningPubMed
PAK2 mediates PhIP-induced proliferative and oxidative stress responses in colorectal cancer cells.Chem Biol Interact202642276320PubTator, text miningPubMed
Comprehensive Clinicopathologic and Molecular Analysis of Mesenchymal Tumors With BRAF Fusions.Genes Chromosomes Cancer202642192570PubTator, text miningPubMed
Evaluation of translational potential of mRNA vaccine candidate antigens for pancreatic cancer: a systematic review based on clinical evidence and stratified prioritization strategies.Front Immunol202642131338PubTator, text miningPubMed

1 to 10 of 2,274

See all 2,274 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5062

GET https://conductscience.org/api/genes/v1/5062/patents?page=2