Gene · 5062
PAK2: p21 (RAC1) activated kinase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PAK2: p21 (RAC1) activated kinase 2. Genes, record 5062. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5062
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13177 | Serine/threonine-protein kinase PAK 2 | 524 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents27
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 56838 | Q13177 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4940 | Q13177 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4940 | Q13177 | Espacenet |
| US 11708396 B2 | 2023-07-25 | 1831 | Q13177 | Espacenet |
| US 11685954 B2 | 2023-06-27 | 46 | Q13177 | Espacenet |
| US 11685954 B2 | 2023-06-27 | 47 | Q13177 | Espacenet |
| US 11685954 B2 | 2023-06-27 | 48 | Q13177 | Espacenet |
| US 11685954 B2 | 2023-06-27 | 50 | Q13177 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 60791 | Q13177 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 163762 | Q13177 | Espacenet |
1 to 10 of 27
See all 27 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,718
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PAK2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 23 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 6 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 4 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 4 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 4 | 2025 |
| R01GM102262 | LIM domain kinases: regulation and substrate recognition | 4 | 2025 |
| R01MH071316 | Rac-GEF signaling in dendritic spines | 4 | 2025 |
1 to 10 of 1,718Source NIH's project files
See all 1,718 nih grantsPapers2,274
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| DISC1 Orchestrates Mitochondrial Calcium Overload in Diabetic Encephalopathy Through a Dual Nucleocytoplasmic Mechanism. | Biomolecules | 2026 | 42793198 | PubTator, text mining | PubMed |
| Phosphorylation Protects Oncogenic RAS from LZTR1-Mediated Degradation. | Blood Cancer Discov | 2026 | 42671911 | PubTator, text mining | PubMed |
| Identification of a nuclear transcriptional module associated with ERα and E2F/FOXM1 signaling across PAM50 breast cancer subtypes. | Front Oncol | 2026 | 42620280 | PubTator, text mining | PubMed |
Cellular Logistics and Synaptic Vesicle Vulnerability in Major Depressive Disorder and Amyotrophic Lateral Sclerosis Comorbidity: Insights From Nicotinamide Mononucleotide Rescue and Transcriptome-Wide Association Study Integration. | Cureus | 2026 | 42529685 | PubTator, text mining | PubMed |
| Deciphering Site-Specific Regulatory Networks of the Kinesin Protein KIF21A Through Integrative Phosphoproteomic Analysis. | Int J Mol Sci | 2026 | 42511730 | PubTator, text mining | PubMed |
| Identification of DNA sequence variants in the Vasculo-Behcet disease patient using whole exome sequencing: a pilot study from Pakistan. | Sci Rep | 2026 | 42386946 | PubTator, text mining | PubMed |
| Phosphorylated HAND1 contributes to trophoblast cell migration during placentation by activating the Vav2-Rac1-PAK signaling. | Eur J Pharmacol | 2026 | 42361881 | PubTator, text mining | PubMed |
| PAK2 mediates PhIP-induced proliferative and oxidative stress responses in colorectal cancer cells. | Chem Biol Interact | 2026 | 42276320 | PubTator, text mining | PubMed |
| Comprehensive Clinicopathologic and Molecular Analysis of Mesenchymal Tumors With BRAF Fusions. | Genes Chromosomes Cancer | 2026 | 42192570 | PubTator, text mining | PubMed |
| Evaluation of translational potential of mRNA vaccine candidate antigens for pancreatic cancer: a systematic review based on clinical evidence and stratified prioritization strategies. | Front Immunol | 2026 | 42131338 | PubTator, text mining | PubMed |
1 to 10 of 2,274
See all 2,274 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5062
GET https://conductscience.org/api/genes/v1/5062/patents?page=2