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Gene · 5063

PAK3: p21 (RAC1) activated kinase 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PAK3: p21 (RAC1) activated kinase 3. Genes, record 5063. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5063

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Gene

Symbol
PAK3
HGNC
Name
p21 (RAC1) activated kinase 3
HGNC
NCBI Gene ID
5063
NCBI Gene
HGNC ID
HGNC:8592
HGNC
Ensembl
ENSG00000077264
NCBI Gene
Aliases
ARA, MRX30, MRX47, OPHN3, PAK-3, PAK3beta, XLID30, bPAK, beta-PAK, hPAK3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75914Serine/threonine-protein kinase PAK 35591Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456839O75914Espacenet
JP 2026004568 A2026-01-1456842O75914Espacenet
EP 4641201 A22025-10-291696O75914Espacenet
JP 2025517969 A2025-06-121696O75914Espacenet
JP 2023536814 A2023-08-307182O75914Espacenet
KR 1020230049661 A2023-04-137165O75914Espacenet
US 11446398 B22022-09-2060793O75914Espacenet
US 11446398 B22022-09-2060796O75914Espacenet
JP 2022524081 A2022-04-27163764O75914Espacenet
JP 2022524081 A2022-04-27163767O75914Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants976

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePAK3 papersNewest fiscal year
P30CA006927Comprehensive Cancer Center Program at Fox Chase92025
P30CA016672Cancer Center Support Grant52025
R01MH071316Rac-GEF signaling in dendritic spines52025
P30CA006973Regional Oncology Research Center32025
P30CA008748Cancer Center Support Grant32025
P30CA016056Roswell Park Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
P30CA077598Cancer Center Support Grant32025
P50CA098252SPORE in Cervical Cancer32025
R01GM102262LIM domain kinases: regulation and substrate recognition32025

1 to 10 of 976Source NIH's project files

See all 976 nih grants

Papers1,511

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
AI-powered histopathology classifiers identify transcriptomic biomarkers associated with cell cycle regulation and increased mitotic activity in poorly differentiated neuroendocrine carcinoma.Hum Genomics202642800881PubTator, text miningPubMed
Correlation between Antiretinal Antibodies and OCT Manifestations in Nonparaneoplastic Autoimmune Retinopathy.Ophthalmol Sci202642437120PubTator, text miningPubMed
Integrative transcriptomic analysis reveals novel targets for personalized medicine across seven metastatic breast cancer subtypes.Sci Rep202642120607PubTator, text miningPubMed
Editorial Expression of Concern: Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation.Nat Commun202641882015PubTator, text miningPubMed
Clinicopathologic and Genetic Analysis of Inverted Follicular Keratosis With Emphasis on Its Similarity to Seborrheic Keratosis.J Cutan Pathol202641850715PubTator, text miningPubMed
Identification of MTURN as a trained immunity-related biomarker for heart failure via integrative transcriptomic machine learning analysis and experimental validation.Front Immunol202641789108PubTator, text miningPubMed
Cancer-associated fibroblasts drive gemcitabine resistance in pancreatic cancer by promoting ferroptosis resistance via the PAX6/PAK3/SLC3A2 axis.Cancer Lett202641786277PubTator, text miningPubMed
Frequency and severity of 192 foods causing food allergy in adults.J Allergy Clin Immunol Glob202641777454PubTator, text miningPubMed
Precision Medicine in Plant Food Allergy: a Systematic Review of Biomarkers Under a Clinical Approach.Clin Rev Allergy Immunol202641739332PubTator, text miningPubMed
The role of gut microbes in production of aromatic carboxaldehydes.Gut Microbes202641723571PubTator, text miningPubMed

1 to 10 of 1,511

See all 1,511 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5063

GET https://conductscience.org/api/genes/v1/5063/patents?page=2