Gene · 5063
PAK3: p21 (RAC1) activated kinase 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PAK3: p21 (RAC1) activated kinase 3. Genes, record 5063. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5063
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O75914 | Serine/threonine-protein kinase PAK 3 | 559 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents23
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 56839 | O75914 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 56842 | O75914 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1696 | O75914 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1696 | O75914 | Espacenet |
| JP 2023536814 A | 2023-08-30 | 7182 | O75914 | Espacenet |
| KR 1020230049661 A | 2023-04-13 | 7165 | O75914 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 60793 | O75914 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 60796 | O75914 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 163764 | O75914 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 163767 | O75914 | Espacenet |
1 to 10 of 23
See all 23 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants976
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PAK3 papers | Newest fiscal year |
|---|---|---|---|
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 9 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| R01MH071316 | Rac-GEF signaling in dendritic spines | 5 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| P30CA077598 | Cancer Center Support Grant | 3 | 2025 |
| P50CA098252 | SPORE in Cervical Cancer | 3 | 2025 |
| R01GM102262 | LIM domain kinases: regulation and substrate recognition | 3 | 2025 |
1 to 10 of 976Source NIH's project files
See all 976 nih grantsPapers1,511
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| AI-powered histopathology classifiers identify transcriptomic biomarkers associated with cell cycle regulation and increased mitotic activity in poorly differentiated neuroendocrine carcinoma. | Hum Genomics | 2026 | 42800881 | PubTator, text mining | PubMed |
| Correlation between Antiretinal Antibodies and OCT Manifestations in Nonparaneoplastic Autoimmune Retinopathy. | Ophthalmol Sci | 2026 | 42437120 | PubTator, text mining | PubMed |
| Integrative transcriptomic analysis reveals novel targets for personalized medicine across seven metastatic breast cancer subtypes. | Sci Rep | 2026 | 42120607 | PubTator, text mining | PubMed |
| Editorial Expression of Concern: Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation. | Nat Commun | 2026 | 41882015 | PubTator, text mining | PubMed |
| Clinicopathologic and Genetic Analysis of Inverted Follicular Keratosis With Emphasis on Its Similarity to Seborrheic Keratosis. | J Cutan Pathol | 2026 | 41850715 | PubTator, text mining | PubMed |
| Identification of MTURN as a trained immunity-related biomarker for heart failure via integrative transcriptomic machine learning analysis and experimental validation. | Front Immunol | 2026 | 41789108 | PubTator, text mining | PubMed |
| Cancer-associated fibroblasts drive gemcitabine resistance in pancreatic cancer by promoting ferroptosis resistance via the PAX6/PAK3/SLC3A2 axis. | Cancer Lett | 2026 | 41786277 | PubTator, text mining | PubMed |
| Frequency and severity of 192 foods causing food allergy in adults. | J Allergy Clin Immunol Glob | 2026 | 41777454 | PubTator, text mining | PubMed |
| Precision Medicine in Plant Food Allergy: a Systematic Review of Biomarkers Under a Clinical Approach. | Clin Rev Allergy Immunol | 2026 | 41739332 | PubTator, text mining | PubMed |
| The role of gut microbes in production of aromatic carboxaldehydes. | Gut Microbes | 2026 | 41723571 | PubTator, text mining | PubMed |
1 to 10 of 1,511
See all 1,511 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5063
GET https://conductscience.org/api/genes/v1/5063/patents?page=2