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Gene · 5066

PAM: peptidylglycine alpha-amidating monooxygenase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PAM: peptidylglycine alpha-amidating monooxygenase. Genes, record 5066. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5066

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Gene

Symbol
PAM
HGNC
Name
peptidylglycine alpha-amidating monooxygenase
HGNC
NCBI Gene ID
5066
NCBI Gene
HGNC ID
HGNC:8596
HGNC
Ensembl
ENSG00000145730
NCBI Gene
Aliases
PAL, PAM-1, PHM
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P19021Peptidyl-glycine alpha-amidating monooxygenase9730Ensembl, GeneID, HGNC

Source UniProt

Patents54

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026510789 A2026-04-101P19021Espacenet
JP 2026004568 A2026-01-1457293P19021Espacenet
JP 2025172069 A2025-11-20374P19021Espacenet
EP 4650780 A22025-11-1912787P19021Espacenet
EP 4640849 A22025-10-292144P19021Espacenet
EP 4641201 A22025-10-2914228P19021Espacenet
JP 2025147176 A2025-10-069974P19021Espacenet
JP 2025529142 A2025-09-043333P19021Espacenet
JP 2025529142 A2025-09-047263P19021Espacenet
US 12371689 B22025-07-293333P19021Espacenet

1 to 10 of 54

See all 54 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,033

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePAM papersNewest fiscal year
R01DK031450Mechanistic Intermediates in Copper Oxygenases and Oxidases222025
P30DK116074Stanford Diabetes Research Center62025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION42025
ZIAHG000024Genetic analysis of type II diabetes42025
P30CA008748Cancer Center Support Grant32025
P30DA018310Neurometabolomics and Neuroproteomics Center on Cell-Cell Signaling32025
P30DA018343Yale/NIDA Neuroproteomics Center32025
P30GM133894A Synchrotron Radiation Structural Biology Resource32025
R01DK093757Genetic epidemiology of rare and regulatory variants for metabolic traits32025

1 to 10 of 1,033Source NIH's project files

See all 1,033 nih grants

Papers2,423

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Impaired peptide amidation and risk of incident dementia in the Malmoe preventive project cohort.Alzheimers Res Ther202642811373PubTator, text miningPubMed
Haplotype-resolved autotetraploid genome of Dioscorea nipponica provides insights into recent polyploidization, metabolic rewiring, and environmental adaptation.Plant J202642804372PubTator, text miningPubMed
Genetically supported targets and drug repurposing for sleep disorders: a Mendelian randomization systematic study.Naunyn Schmiedebergs Arch Pharmacol202642760376PubTator, text miningPubMed
Evolution and Expression Divergence of Legume PAL Genes Suggest Associations with Drought Response and Root Nodule Development.J Agric Food Chem202642715939PubTator, text miningPubMed
Takotsubo syndrome diagnosis: the biomarker-based BioTAK score.Eur Heart J202642670759PubTator, text miningPubMed
Adrenomedullin system dysregulation predicts cardiogenic shock and mortality in acute coronary syndromes.Eur Heart J202642668424PubTator, text miningPubMed
Effects of Electrolyzed Functional Water Combined with Modified Atmosphere Storage on Postharvest Quality of Arrow Bamboo Shoots.Foods202642650592PubTator, text miningPubMed
Concentration-Dependent Effects of Salicylic Acid and Methyl Salicylate on Chlorophylls, Carotenoids, Fatty Acids, and Phenolic Compounds in the Green Microalga Planktochlorella nurekis.Mar Drugs202642646483PubTator, text miningPubMed
Genomes of Poaceae relatives reveal key metabolic innovations preceding the evolution of grasses.Science202642623474PubTator, text miningPubMed
Tri-frequency ultrasonication priming enhances germination, nutritional quality and techno-functional properties of tartary buckwheat.Ultrason Sonochem202642604605PubTator, text miningPubMed

1 to 10 of 2,423

See all 2,423 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5066

GET https://conductscience.org/api/genes/v1/5066/patents?page=2