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Gene · 5069

PAPPA: pappalysin 1

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. PAPPA: pappalysin 1. Genes, record 5069. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/5069

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
PAPPA
HGNC
Name
pappalysin 1
HGNC
NCBI Gene ID
5069
NCBI Gene
HGNC ID
HGNC:8602
HGNC
Ensembl
ENSG00000182752
NCBI Gene
Aliases
ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13219Pappalysin-11,6278Ensembl, GeneID, HGNC

Source UniProt

Patents57

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026219836 A12026-10-2257Q13219Espacenet
US 12606639 B22026-04-211Q13219Espacenet
JP 2026004568 A2026-01-1458988Q13219Espacenet
JP 2025539937 A2025-12-1079Q13219Espacenet
WO 2025242652 A12025-11-271Q13219Espacenet
EP 4650780 A22025-11-195868Q13219Espacenet
EP 4641201 A22025-10-295590Q13219Espacenet
JP 2025147176 A2025-10-069992Q13219Espacenet
EP 4619023 A12025-09-2479Q13219Espacenet
JP 2025529142 A2025-09-047266Q13219Espacenet

1 to 10 of 57

See all 57 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,176

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
T32DK007352Diabetes and Metabolism82025
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition82025
K12HD000849Reproductive Scientist Development Program42025
R37AG013925Effect of Aging on Preadipocyte Differentiation42025
P30CA016672Cancer Center Support Grant32025
P30CA047904Cancer Center Support Grant32025
P50HD103555Baylor College of Medicine Intellectual and Developmental Disabilities Research Center32025
R01DK075787Biological Insights from Genetic Investigation of ANthropometric Traits (GIANT) Across the Allelic Spectrum32025
R01HD055651Prenatal Genetic Diagnosis by Genomic Sequencing: A Prospective Evaluation32025
R35GM126956Discovery and mechanisms of biosynthetic enzymes32025

1 to 10 of 1,176Source NIH's project files

See all 1,176 nih grants

Papers4,258

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42801806PubTator, text miningPubMed
42796410PubTator, text miningPubMed
42794985PubTator, text miningPubMed
42793480PubTator, text miningPubMed
42766089PubTator, text miningPubMed
42759252PubTator, text miningPubMed
42739747PubTator, text miningPubMed
42732549PubTator, text miningPubMed
42732391PubTator, text miningPubMed
42725516PubTator, text miningPubMed

1 to 10 of 4,258

See all 4,258 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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