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PRKN: parkin RBR E3 ubiquitin protein ligase

1 protein, 55 patents, 0 drugs, 0 trials, 6,270 NIH grants and 15,505 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPRKNHGNC
Nameparkin RBR E3 ubiquitin protein ligaseHGNC
NCBI Gene ID5071NCBI Gene
HGNC IDHGNC:8607HGNC
EnsemblENSG00000185345NCBI Gene
AliasesAR-JP, LPRS2, PARK2, PDJ, parkinNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O60260E3 ubiquitin-protein ligase parkin46521Ensembl, GeneID, HGNCUniProt

Patents 55

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4770680 A12026-07-0811O60260Espacenet
JP 2026108757 A2026-06-307O60260Espacenet
JP 2026507518 A2026-03-04157O60260Espacenet
US 12539325 B22026-02-0358O60260Espacenet
JP 2026004568 A2026-01-1457112O60260Espacenet
EP 4665771 A12025-12-24157O60260Espacenet
EP 4641201 A22025-10-298277O60260Espacenet
US 12351611 B22025-07-087O60260Espacenet
JP 2025517969 A2025-06-128277O60260Espacenet
US 12274699 B22025-04-1510O60260Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 6270

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIANS003123Role of mitochondria in neurodegenerative diseases382,025NIH's project files
R01ES010563Mechanisms of Manganese Neurotoxicity372,025NIH's project files
P30CA008748Cancer Center Support Grant302,025NIH's project files
R01ES007331Mechanisms of Methylmercury Induced Neuronal Toxicity242,025NIH's project files
ZIANS003127Mechanisms of Autophagy222,025NIH's project files
P40OD010440Caenorhabditis Genetics Center172,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award162,025NIH's project files
P30CA016672Cancer Center Support Grant152,025NIH's project files
ZIAAG000953DJ-1 and hexokinases152,025NIH's project files
ZIANS003154Genetic characterization of atypical parkinsonism152,025NIH's project files

Papers 15505

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42817107PubTator, text miningPubMed
42817106PubTator, text miningPubMed
42815263PubTator, text miningPubMed
42815086PubTator, text miningPubMed
42814283PubTator, text miningPubMed
42813713PubTator, text miningPubMed
42812598PubTator, text miningPubMed
42806156PubTator, text miningPubMed
42803978PubTator, text miningPubMed
42802722PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license