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Gene · 5093

PCBP1: poly(rC) binding protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PCBP1: poly(rC) binding protein 1. Genes, record 5093. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5093

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Gene

Symbol
PCBP1
HGNC
Name
poly(rC) binding protein 1
HGNC
NCBI Gene ID
5093
NCBI Gene
HGNC ID
HGNC:8647
HGNC
Ensembl
ENSG00000169564
NCBI Gene
Aliases
HEL-S-85, HNRPE1, HNRPX, hnRNP-E1, hnRNP-X
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15365Poly(rC)-binding protein 13563Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458361Q15365Espacenet
EP 4650780 A22025-11-194353Q15365Espacenet
EP 4641201 A22025-10-293896Q15365Espacenet
JP 2025147176 A2025-10-0615473Q15365Espacenet
JP 2025517969 A2025-06-123896Q15365Espacenet
JP 2025517970 A2025-06-124353Q15365Espacenet
JP 2025032204 A2025-03-1133051Q15365Espacenet
JP 2025028160 A2025-02-2815473Q15365Espacenet
KR 1020250010750 A2025-01-2115473Q15365Espacenet
EP 4461818 A22024-11-1333051Q15365Espacenet

1 to 10 of 41

See all 41 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,103

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePCBP1 papersNewest fiscal year
R01CA154663TGFbeta-regulated epithelial-mesenchymal transition (EMT)202025
ZIADK054510Identification of human genes of iron homeostasis182025
P30CA008748Cancer Center Support Grant52025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant52025
ZIABC010419Molecular Mechanisms of TGF-beta Signaling Pathway52025
U54DK110858Center for Iron & Heme Disorders at the University of Utah42025
ZIAHD008814Mammalian iron-sulfur cluster biogenesis42025
P01CA013106Targeting Transcription and Splicing in Cancer32025
P01CA092584Structural Cell Biology of DNA Repair Machines32025
P30CA016058Cancer Center Support Grant32025

1 to 10 of 1,103Source NIH's project files

See all 1,103 nih grants

Papers1,671

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Promising reference genes for RT-qPCR normalization in breast tumors and normal adjacent tissues.Mol Biol Rep202642801429PubTator, text miningPubMed
De novo variants in the poly(rC)-binding protein gene PCBP1 cause a neurodevelopmental disorder.Mol Psychiatry202642749777PubTator, text miningPubMed
Corrigendum to "TBBPA induced hepatocyte ferroptosis by PCBP1-mediated ferritinophagy" [J Hazard Mater 494 (2025) 138515].J Hazard Mater202642692919PubTator, text miningPubMed
PCBP1 Joins the Regulatory Network of the Endothelial-to-Hematopoietic Transition.Exp Hematol202642603606PubTator, text miningPubMed
TDP-43 drives ferroptosis evasion by modulating PCBP1/PCBP2 axis to promote lung adenocarcinoma growth.Redox Biol202642585793PubTator, text miningPubMed
The emerging role of ZDHHC9 in cancer: from protein palmitoylation to tumor progression and immune regulation.Front Immunol202642528569PubTator, text miningPubMed
Colorectal cancer-associated PCBP1 mutations disrupt protein stability in a dominant-negative manner.J Biol Chem202642520935PubTator, text miningPubMed
"Lights, camera, (ac)tion!": Damage-induced PCBP1 deacetylation releases PARP1 to engage DNA double-strand breaks.Mol Cell202642462698PubTator, text miningPubMed
APE1 binds and processes abasic sites present in i-motif DNA and cooperates with PCBP1 in maintenance of telomeric stability.Nucleic Acids Res202642417194PubTator, text miningPubMed
A P-body-related risk score predicts prognosis and immune microenvironment in lung adenocarcinoma.Transl Cancer Res202642305460PubTator, text miningPubMed

1 to 10 of 1,671

See all 1,671 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5093

GET https://conductscience.org/api/genes/v1/5093/patents?page=2