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SOST: sclerostin

1 protein, 248 patents, 5 drugs, 38 trials, 2,023 NIH grants and 6,157 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSOSTHGNC
NamesclerostinHGNC
NCBI Gene ID50964NCBI Gene
HGNC IDHGNC:13771HGNC
EnsemblENSG00000167941NCBI Gene
AliasesCDD, DAND6, SOST1, VBCHNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9BQB4Sclerostin2133Ensembl, GeneID, HGNCUniProt

Patents 248

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026095400 A2026-06-101Q9BQB4Espacenet
WO 2026048885 A2026-03-0514Q9BQB4Espacenet
JP 2026034588 A2026-02-277Q9BQB4Espacenet
JP 2026004467 A2026-01-147Q9BQB4Espacenet
JP 2026004568 A2026-01-1462730Q9BQB4Espacenet
EP 4650780 A22025-11-194092Q9BQB4Espacenet
JP 2025147176 A2025-10-0612639Q9BQB4Espacenet
JP 2025529142 A2025-09-047767Q9BQB4Espacenet
US 12371689 B22025-07-297767Q9BQB4Espacenet
US 12351822 B22025-07-087Q9BQB4Espacenet

Drugs 5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMG-167CHEMBL2109571Sclerostin inhibitorINHIBITORChEMBL
ANTI-SCLEROSTINCHEMBL2109572Sclerostin inhibitorINHIBITORChEMBL
BLOSOZUMABCHEMBL1742993Sclerostin inhibitorINHIBITORChEMBL
ROMOSOZUMABCHEMBL2107874Sclerostin inhibitorINHIBITORChEMBL
SETRUSUMABCHEMBL4297918Sclerostin inhibitorINHIBITORChEMBL

Trials 38

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07283887ROMOSOZUMABPHASE4ClinicalTrials.gov
NCT06973109ROMOSOZUMABPHASE2ClinicalTrials.gov
NCT06938152ROMOSOZUMABPHASE4ClinicalTrials.gov
NCT06811363ROMOSOZUMABClinicalTrials.gov
NCT06720350ROMOSOZUMABPHASE4ClinicalTrials.gov
NCT06636071SETRUSUMABPHASE3ClinicalTrials.gov
NCT06558188ROMOSOZUMABPHASE4ClinicalTrials.gov
NCT06472050ROMOSOZUMABPHASE4ClinicalTrials.gov
NCT06164795ROMOSOZUMABClinicalTrials.gov
NCT06079476ROMOSOZUMABPHASE4ClinicalTrials.gov

NIH grants 2023

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01AR053237Lrp5 and Lrp6 signaling in bone mechanotransduction and metabolism282,025NIH's project files
P20GM125503Center for Musculoskeletal Disease Research (CMDR)152,025NIH's project files
I01BX001478Harnessing the anabolic potential of Wnt signaling to improve bone health132,025NIH's project files
P01AG062413Targeting Cellular Senescence to Extend Healthspan122,025NIH's project files
P20GM121301Phase II COBRE in Mesenchymal and Neural Regulation of Metabolic Networks122,025NIH's project files
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)122,025NIH's project files
R01AR041398Novel Molecular Biomarkers of Bone Microarchitecture122,025NIH's project files
R01CA209882Contribution of osteocytes to the musculoskeletal effects of Multiple Myeloma92,025NIH's project files
T32AR065971Comprehensive Musculoskeletal Training Program92,025NIH's project files
P30AR069620Michigan Integrative Musculoskeletal Health Core Center (Overall Application)82,025NIH's project files

Papers 6157

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825685PubTator, text miningPubMed
42808166PubTator, text miningPubMed
42804367PubTator, text miningPubMed
42787268PubTator, text miningPubMed
42786882PubTator, text miningPubMed
42786145PubTator, text miningPubMed
42784573PubTator, text miningPubMed
42781632PubTator, text miningPubMed
42761784PubTator, text miningPubMed
42761068PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license