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Gene · 51024

FIS1: fission, mitochondrial 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FIS1: fission, mitochondrial 1. Genes, record 51024. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51024

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Gene

Symbol
FIS1
HGNC
Name
fission, mitochondrial 1
HGNC
NCBI Gene ID
51024
NCBI Gene
HGNC ID
HGNC:21689
HGNC
Ensembl
ENSG00000214253
NCBI Gene
Aliases
CGI-135, H_NH0132A01.6, TTC11
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y3D6Mitochondrial fission 1 protein15212Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1446374Q9Y3D6Espacenet
EP 4650780 A22025-11-19587Q9Y3D6Espacenet
JP 2025529142 A2025-09-041576Q9Y3D6Espacenet
US 12371689 B22025-07-291576Q9Y3D6Espacenet
JP 2025517970 A2025-06-12587Q9Y3D6Espacenet
EP 4484957 A12025-01-01234Q9Y3D6Espacenet
WO 2023162878 A2023-08-31234Q9Y3D6Espacenet
US 11446398 B22022-09-2032181Q9Y3D6Espacenet
US 11400116 B22022-08-024160Q9Y3D6Espacenet
JP 2022524081 A2022-04-27135152Q9Y3D6Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,753

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFIS1 papersNewest fiscal year
ZIANS002859Targeting Protein Aggregates for Autophagosomal Degradation142025
ZIANS003123Role of mitochondria in neurodegenerative diseases112025
P30AG028740University of Florida Older Americans Independence Center (OAIC)82025
ZIANS003127Mechanisms of Autophagy82025
R01AA011147Ethanol and aldehyde dehydrogenases in health and disease72025
P30CA014195Cancer Center Support Grant (CCSG)52025
P30CA033572Cancer Center Support Grant52025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center52025
R01HL091469Cysteine oxidation in the heart52025
R01MH128022Defining brain pericytes as a novel and myeloid-derived HIV reservoir52025

1 to 10 of 1,753Source NIH's project files

See all 1,753 nih grants

Papers3,164

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Polydatin improves mitochondrial dynamics dysrhythmia by regulating BMAL1 to prevent and treat metabolic dysfunction-associated fatty liver disease.J Ethnopharmacol202742468884PubTator, text miningPubMed
Mitochondrial Quality Control: A Gatekeeper of Spermatogenesis.J Vis Exp202642813713PubTator, text miningPubMed
Benzamil-induced cytotoxicity in non-small cell lung cancer is associated with mitochondrial damage, mitochondrial elongation, and altered XIAP signaling.J Pharmacol Sci202642810781PubTator, text miningPubMed
Mitophagy-Related Gene Dysregulation: Links With Telomere Attrition and Impaired Lung Function in Sulfur Mustard-Exposed Veterans.J Appl Toxicol202642775893PubTator, text miningPubMed
Recent advances in mitochondrial fission and fusion in diabetic cardiomyopathy.Front Cardiovasc Med202642761440PubTator, text miningPubMed
ARMC10 (S43) phosphorylation mediates trimethyltin chloride-induced cognitive impairment through mitochondrial dynamics disruption.J Hazard Mater202642748816PubTator, text miningPubMed
Mitochondrial Fis1 tunes Rab7A activity via TBC1D15 modulating STING degradation.Cell Rep202642715104PubTator, text miningPubMed
Septic Cardiomyopathy and Mitochondrial Quality Control.Front Biosci (Landmark Ed)202642690004PubTator, text miningPubMed
Lactylation in sepsis-associated acute kidney injury: regulatory mechanisms and therapeutic prospects.Front Mol Biosci202642688716PubTator, text miningPubMed
Long-read sequencing reveals widespread novel splicing and neojunction-derived neoantigens in nasopharyngeal carcinoma.Genome Res202642680560PubTator, text miningPubMed

1 to 10 of 3,164

See all 3,164 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/51024

GET https://conductscience.org/api/genes/v1/51024/patents?page=2