Gene · 5105
PCK1: phosphoenolpyruvate carboxykinase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PCK1: phosphoenolpyruvate carboxykinase 1. Genes, record 5105. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5105
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P35558 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 622 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents28
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 57790 | P35558 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5272 | P35558 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 5272 | P35558 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 33107 | P35558 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 33107 | P35558 | Espacenet |
| JP 2024517713 A | 2024-04-23 | 204 | P35558 | Espacenet |
| KR 1020240007179 A | 2024-01-16 | 73 | P35558 | Espacenet |
| US 11795436 B2 | 2023-10-24 | 26 | P35558 | Espacenet |
| JP 2023123507 A | 2023-09-05 | 338 | P35558 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 33107 | P35558 | Espacenet |
1 to 10 of 28
See all 28 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,671
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PCK1 papers | Newest fiscal year |
|---|---|---|---|
| P30DK045735 | Yale Diabetes Research Center | 9 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 9 | 2025 |
| P20GM113226 | Hepatobiology and Toxicology COBRE | 6 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 6 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 6 | 2025 |
| R01DA012864 | Mechanisms and Cellular Function of Opioid Receptor Endocytosis | 6 | 2025 |
| P30DK034989 | Yale Liver Center | 5 | 2025 |
| P30DK036836 | Diabetes Research Center | 5 | 2025 |
| T32ES011564 | UOFL ENVIRONMENTAL HEALTH SCIENCES TRAINING PROGRAM | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,671Source NIH's project files
See all 1,671 nih grantsPapers3,855
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Catechin-driven dual metabolic modulation enhances docosahexaenoic acid biosynthesis and oxidative stability in Schizochytrium sp. | Bioresour Technol | 2027 | 42632469 | PubTator, text mining | PubMed |
| PCK1 promotes gastric cancer progression by activating the SRC1-JAK1-STAT3 signaling axis. | Transl Oncol | 2026 | 42805114 | PubTator, text mining | PubMed |
| Integrative transcriptomic analysis links epithelial PCK1 dysregulation to ulcerative colitis and acetyl-l-carnitine-mediated inflammatory modulation. | Int Immunopharmacol | 2026 | 42777672 | PubTator, text mining | PubMed |
| Unravelling gut-kidney axis alterations in BPA-related CKD: Integrating network toxicology and machine learning with experimental validation. | Ecotoxicol Environ Saf | 2026 | 42771980 | PubTator, text mining | PubMed |
| Kinetic model of a determinate legume root nodule reveals plant metabolic characteristics for more efficient nitrogen fixation symbiosis. | Metab Eng | 2026 | 42744014 | PubTator, text mining | PubMed |
Branched-Chain Amino Acid Supplementation Exerts Opposite Effects on Offspring Growth and Differentially Affects Maternal Glucose and Lipid Metabolism in Lactating Dams Fed Normal- or Low-Protein Diets. | Nutrients | 2026 | 42739040 | PubTator, text mining | PubMed |
| The tire antioxidant derivative 6PPD-quinone exacerbates IBD by targeting NR1H4-mediated lipid metabolism and mitochondrial dysfunction in human colon epithelial cells. | Food Chem Toxicol | 2026 | 42697461 | PubTator, text mining | PubMed |
| Oxaloacetate damages mitochondria by perturbing MIC60-dependent membrane remodeling. | PLoS Biol | 2026 | 42664297 | PubTator, text mining | PubMed |
| Dominant Effect of Ecological Restoration on Microbial Carbon Cycle in Plant Rhizosphere of Mining Areas. | Microorganisms | 2026 | 42655058 | PubTator, text mining | PubMed |
| ERS-mediated metabolic toxicity: The IRE1α/XBP1s pathway as a critical driver of Cr(VI)-Induced disruption in glucose and lipid metabolism. | Chem Biol Interact | 2026 | 42617994 | PubTator, text mining | PubMed |
1 to 10 of 3,855
See all 3,855 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5105
GET https://conductscience.org/api/genes/v1/5105/patents?page=2