ConductScience.org, home

Gene · 5105

PCK1: phosphoenolpyruvate carboxykinase 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. PCK1: phosphoenolpyruvate carboxykinase 1. Genes, record 5105. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5105

On this page

Gene

Symbol
PCK1
HGNC
Name
phosphoenolpyruvate carboxykinase 1
HGNC
NCBI Gene ID
5105
NCBI Gene
HGNC ID
HGNC:8724
HGNC
Ensembl
ENSG00000124253
NCBI Gene
Aliases
PCKDC, PEPCK-C, PEPCK1, PEPCKC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35558Phosphoenolpyruvate carboxykinase, cytosolic [GTP]6227Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457790P35558Espacenet
EP 4650780 A22025-11-195272P35558Espacenet
JP 2025517970 A2025-06-125272P35558Espacenet
JP 2025032204 A2025-03-1133107P35558Espacenet
EP 4461818 A22024-11-1333107P35558Espacenet
JP 2024517713 A2024-04-23204P35558Espacenet
KR 1020240007179 A2024-01-1673P35558Espacenet
US 11795436 B22023-10-2426P35558Espacenet
JP 2023123507 A2023-09-05338P35558Espacenet
JP 2023058610 A2023-04-2533107P35558Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,671

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePCK1 papersNewest fiscal year
P30DK045735Yale Diabetes Research Center92025
UL1TR001863Yale Clinical and Translational Science Award92025
P20GM113226Hepatobiology and Toxicology COBRE62025
P30CA021765Cancer Center Support Grant (CCSG)62025
P30DK034854Integrated Epithelial and Muscosal Biology62025
R01DA012864Mechanisms and Cellular Function of Opioid Receptor Endocytosis62025
P30DK034989Yale Liver Center52025
P30DK036836Diabetes Research Center52025
T32ES011564UOFL ENVIRONMENTAL HEALTH SCIENCES TRAINING PROGRAM52025
P30CA016672Cancer Center Support Grant42025

1 to 10 of 1,671Source NIH's project files

See all 1,671 nih grants

Papers3,855

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Catechin-driven dual metabolic modulation enhances docosahexaenoic acid biosynthesis and oxidative stability in Schizochytrium sp.Bioresour Technol202742632469PubTator, text miningPubMed
PCK1 promotes gastric cancer progression by activating the SRC1-JAK1-STAT3 signaling axis.Transl Oncol202642805114PubTator, text miningPubMed
Integrative transcriptomic analysis links epithelial PCK1 dysregulation to ulcerative colitis and acetyl-l-carnitine-mediated inflammatory modulation.Int Immunopharmacol202642777672PubTator, text miningPubMed
Unravelling gut-kidney axis alterations in BPA-related CKD: Integrating network toxicology and machine learning with experimental validation.Ecotoxicol Environ Saf202642771980PubTator, text miningPubMed
Kinetic model of a determinate legume root nodule reveals plant metabolic characteristics for more efficient nitrogen fixation symbiosis.Metab Eng202642744014PubTator, text miningPubMed
Branched-Chain Amino Acid Supplementation Exerts Opposite Effects on Offspring Growth and Differentially Affects Maternal Glucose and Lipid Metabolism in Lactating Dams Fed Normal- or Low-Protein Diets.
Nutrients202642739040PubTator, text miningPubMed
The tire antioxidant derivative 6PPD-quinone exacerbates IBD by targeting NR1H4-mediated lipid metabolism and mitochondrial dysfunction in human colon epithelial cells.Food Chem Toxicol202642697461PubTator, text miningPubMed
Oxaloacetate damages mitochondria by perturbing MIC60-dependent membrane remodeling.PLoS Biol202642664297PubTator, text miningPubMed
Dominant Effect of Ecological Restoration on Microbial Carbon Cycle in Plant Rhizosphere of Mining Areas.Microorganisms202642655058PubTator, text miningPubMed
ERS-mediated metabolic toxicity: The IRE1α/XBP1s pathway as a critical driver of Cr(VI)-Induced disruption in glucose and lipid metabolism.Chem Biol Interact202642617994PubTator, text miningPubMed

1 to 10 of 3,855

See all 3,855 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5105

GET https://conductscience.org/api/genes/v1/5105/patents?page=2