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Gene · 5106

PCK2: phosphoenolpyruvate carboxykinase 2, mitochondrial

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PCK2: phosphoenolpyruvate carboxykinase 2, mitochondrial. Genes, record 5106. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5106

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Gene

Symbol
PCK2
HGNC
Name
phosphoenolpyruvate carboxykinase 2, mitochondrial
HGNC
NCBI Gene ID
5106
NCBI Gene
HGNC ID
HGNC:8725
HGNC
Ensembl
ENSG00000100889
NCBI Gene
Aliases
PEPCK, PEPCK-M, PEPCK2, mtPCK2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16822Phosphoenolpyruvate carboxykinase [GTP], mitochondrial6400Ensembl, GeneID, HGNC

Source UniProt

Patents7

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19366Q16822Espacenet
EP 4641201 A22025-10-29261Q16822Espacenet
JP 2025517969 A2025-06-12261Q16822Espacenet
JP 2025517970 A2025-06-12366Q16822Espacenet
US 11446398 B22022-09-2063024Q16822Espacenet
JP 2022524081 A2022-04-27165995Q16822Espacenet
US 7842467 B12010-11-302814Q16822Espacenet

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,645

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePCK2 papersNewest fiscal year
P30DK045735Yale Diabetes Research Center132025
P30DK020593Vanderbilt Diabetes Research Center122025
T32DK007061Research Training in Diabetes and Endocrinology72025
P30DK019525University of Pennsylvania Diabetes Research Center62025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes52025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)52025
P30DK034989Yale Liver Center52025
P30DK036836Diabetes Research Center52025
R01DK078184Factors Controlling Metabolic Flux in the Liver52025
UL1TR001863Yale Clinical and Translational Science Award52025

1 to 10 of 1,645Source NIH's project files

See all 1,645 nih grants

Papers3,204

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Structural characterization and insulin resistance-improving activity of glucomannogalactan from Volvariella volvacea.Int J Biol Macromol202642826778PubTator, text miningPubMed
Glycolytic reprogramming and cell-specific lactylation in asthma: an evidence-graded framework for testable metabolic-epigenetic profiles.Front Immunol202642813062PubTator, text miningPubMed
Crosstalk between NUAK1 and the SETD1A complex regulates glycolysis and gluconeogenesis upon glucose deprivation.J Biol Chem202642778105PubTator, text miningPubMed
Enterobacteriaceae for succinic acid biomanufacturing: metabolic blueprints, systems-level engineering and future perspectives.Biotechnol Adv202642772475PubTator, text miningPubMed
Targeting PCK2 alleviates GERD by suppressing MAPK-dependent endoplasmic reticulum stress and oxidative stress-induced apoptosis.Biochim Biophys Acta Gen Subj202642692205PubTator, text miningPubMed
Oxaloacetate damages mitochondria by perturbing MIC60-dependent membrane remodeling.PLoS Biol202642664297PubTator, text miningPubMed
PCK2 Inhibition Reverses Cisplatin Resistance of Non-Small Cell Lung Cancer by Triggering Ferroptosis.FASEB J202642599961PubTator, text miningPubMed
Docking Analysis of Drugs Used in the Treatment of Alzheimer's Disease, Using Cell Membrane Receptors and Enzymes of the Kynurenine Pathway: A Pilot Study.Int J Mol Sci202642589213PubTator, text miningPubMed
Circadian Regulation of Glucose Metabolism: Implications for Pathogenesis and Chronotherapy of Type 2 Diabetes.Diabetology (Basel)202642583078PubTator, text miningPubMed
Metformin's disruption of gluconeogenesis in type 2 diabetes impairments of the cori and alanine cycles as hidden drivers of metabolic waste accumulation, NF-κBHIF-1α-mediated low-grade inflammation, and multisystem dysfunction.
Probl Endokrinol (Mosk)202642545322PubTator, text miningPubMed

1 to 10 of 3,204

See all 3,204 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5106

GET https://conductscience.org/api/genes/v1/5106/grants?page=2