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Gene · 51107

APH1A: aph-1A gamma-secretase subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. APH1A: aph-1A gamma-secretase subunit. Genes, record 51107. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51107

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Gene

Symbol
APH1A
HGNC
Name
aph-1A gamma-secretase subunit
HGNC
NCBI Gene ID
51107
NCBI Gene
HGNC ID
HGNC:29509
HGNC
Ensembl
ENSG00000117362
NCBI Gene
Aliases
6530402N02Rik, APH-1, APH-1A, CGI-78
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96BI3Gamma-secretase subunit APH-1A26525Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437617Q96BI3Espacenet
EP 4650780 A22025-11-198572Q96BI3Espacenet
JP 2025529142 A2025-09-04409Q96BI3Espacenet
US 12371689 B22025-07-29409Q96BI3Espacenet
JP 2025517970 A2025-06-128572Q96BI3Espacenet
JP 2025062604 A2025-04-145629Q96BI3Espacenet
US 11446398 B22022-09-205629Q96BI3Espacenet
US 11400116 B22022-08-02974Q96BI3Espacenet
JP 2022524081 A2022-04-27108600Q96BI3Espacenet
WO 2020043864 A12020-03-05175Q96BI3Espacenet

1 to 10 of 21

See all 21 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AVAGACESTATCHEMBL1090771Gamma-secretase inhibitorINHIBITORChEMBL
BEGACESTATCHEMBL463981Gamma-secretase inhibitorINHIBITORChEMBL
NIROGACESTATCHEMBL1770916Gamma-secretase inhibitorINHIBITORChEMBL
NIROGACESTAT HYDROBROMIDECHEMBL4298153Gamma-secretase inhibitorINHIBITORChEMBL
RG-4733CHEMBL4297422Gamma-secretase inhibitorINHIBITORChEMBL
SEMAGACESTATCHEMBL520733Gamma-secretase inhibitorINHIBITORChEMBL
TARENFLURBILCHEMBL190083Gamma-secretase modulatorMODULATORChEMBL

Trials67

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07539454NIROGACESTATPHASE2ClinicalTrials.gov
NCT07176689NIROGACESTATPHASE4ClinicalTrials.gov
NCT07170644NIROGACESTATPHASE2ClinicalTrials.gov
NCT07150104NIROGACESTATPHASE1/PHASE2ClinicalTrials.gov
NCT07150091NIROGACESTATPHASE1/PHASE2ClinicalTrials.gov
NCT07084896NIROGACESTATPHASE1/PHASE2ClinicalTrials.gov
NCT05949099NIROGACESTATPHASE2ClinicalTrials.gov
NCT05879146NIROGACESTATPHASE2ClinicalTrials.gov
NCT05573802NIROGACESTATPHASE1/PHASE2ClinicalTrials.gov
NCT05556798NIROGACESTATPHASE1ClinicalTrials.gov

1 to 10 of 67

See all 67 trials

NIH grants959

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAPH1A papersNewest fiscal year
P30CA008748Cancer Center Support Grant112025
P30CA016672Cancer Center Support Grant62025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)62025
P30CA168524The University of Kansas Cancer Center52025
ZIAAG000311ALZHEIMERS RESEARCH PROJECT: Design And Development Of Experimental Therapeutics ((Systemic & Neurodegenerative Disorders and Alzheimer's Disease)42025
U19AG032438Bridge Funding for Dominantly Inherited Alzheimer Network32025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study22025
P20GM121327University of Kentucky Center for Cancer Metabolism22025
P30CA043703Case Comprehensive Cancer Center Support Grant22025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant22025

1 to 10 of 959Source NIH's project files

See all 959 nih grants

Papers1,260

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
AHA1 Regulates Aβ Production via Modulation of APP Abundance and γ-Secretase Assembly.J Neurochem202642661397PubTator, text miningPubMed
miR-151-5p regulates neural stem cell fate by targeting APH1A to modulate Notch signaling gradients.Stem Cell Reports202642167224PubTator, text miningPubMed
Endogenous APE1-mediated confined catalytic hairpin assembly for high-contrast imaging of miRNA in living cell enables tumor cell-specific recognition.Biosens Bioelectron202642000659PubTator, text miningPubMed
In Silico Structure-Guided Design of Peptide Candidates Targeting γ-Secretase Subunit Assembly.Proteins202641927485PubTator, text miningPubMed
Distinct Regulatory Genomic Architectures Distinguish Early-Onset from Late-Onset Alzheimer's Disease.Genes (Basel)202641751570PubTator, text miningPubMed
Exploring Gene Expression Patterns in Alzheimer's Disease Using a Human Microarray Data Meta-Analysis.Biology (Basel)202641744654PubTator, text miningPubMed
In Silico Phosphoproteomic Analysis Reveals Divergent Regulation of Presenilin 1 and Presenilin 2.Neuromolecular Med202641615513PubTator, text miningPubMed
Deciphering the regulatory landscape of enhancer RNAs in health and disease.Signal Transduct Target Ther202641605892PubTator, text miningPubMed
Subtype-Independent Dysregulation of the Notch Signaling Pathway and Its miRNA Regulators in Breast Cancer.Biomedicines202541463075PubTator, text miningPubMed
The manipulator behind "Scissors": γ -secretase and its modulators in Alzheimer's disease.Front Aging Neurosci202540927393PubTator, text miningPubMed

1 to 10 of 1,260

See all 1,260 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/51107

GET https://conductscience.org/api/genes/v1/51107/patents?page=2