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Gene · 51135

IRAK4: interleukin 1 receptor associated kinase 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IRAK4: interleukin 1 receptor associated kinase 4. Genes, record 51135. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51135

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Gene

Symbol
IRAK4
HGNC
Name
interleukin 1 receptor associated kinase 4
HGNC
NCBI Gene ID
51135
NCBI Gene
HGNC ID
HGNC:17967
HGNC
Ensembl
ENSG00000198001
NCBI Gene
Aliases
IMD67, IPD1, IRAK-4, NY-REN-64, REN64
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NWZ3Interleukin-1 receptor-associated kinase 446096Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450292Q9NWZ3Espacenet
JP 2026004568 A2026-01-1450294Q9NWZ3Espacenet
EP 4650780 A22025-11-1916443Q9NWZ3Espacenet
JP 2025517970 A2025-06-1216443Q9NWZ3Espacenet
EP 4484957 A12025-01-0136Q9NWZ3Espacenet
US 11892452 B22024-02-06148Q9NWZ3Espacenet
JP 2023123507 A2023-09-05314Q9NWZ3Espacenet
WO 2023162878 A2023-08-3136Q9NWZ3Espacenet
US 11701385 B22023-07-18111Q9NWZ3Espacenet
US 11446398 B22022-09-2041721Q9NWZ3Espacenet

1 to 10 of 43

See all 43 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
ZIMLOVISERTIBCHEMBL4081711Interleukin-1 receptor-associated kinase 4 inhibitorINHIBITOR

Source ChEMBL

Trials5

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04933799ZIMLOVISERTIBPHASE2ClinicalTrials.gov
NCT04575610ZIMLOVISERTIBPHASE2ClinicalTrials.gov
NCT04413617ZIMLOVISERTIBPHASE22023-04-07ClinicalTrials.gov
NCT04092452ZIMLOVISERTIBPHASE22023-06-15ClinicalTrials.gov
NCT02996500ZIMLOVISERTIBPHASE22020-02-27ClinicalTrials.gov

NIH grants2,116

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIRAK4 papersNewest fiscal year
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success162025
P30CA008748Cancer Center Support Grant132025
ZIABC011008Oncogenic mechanisms and molecular targets in lymphoma92025
P30DK034854Integrated Epithelial and Muscosal Biology82025
R01AI127564Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis82025
UL1TR001863Yale Clinical and Translational Science Award82025
P30CA016672Cancer Center Support Grant72025
ZIAAI000647Genes And Gene Products As Immunoadjuvants72025
R01AI163029Inborn errors of immunity in patients with life-threatening COVID-1962025
R01CA275007Therapeutic targeting of IRAK4 in MDS52025

1 to 10 of 2,116Source NIH's project files

See all 2,116 nih grants

Papers3,419

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Histone H4 lysine 20 tri-methylation safeguards breast cancer lineage fidelity and unfolded protein response.Nat Commun202642802180PubTator, text miningPubMed
Machine Learning-Driven Drug Repositioning Identifies Putative IRAK4 Inhibitors Through Structure-Based Computational Evaluation.Curr Issues Mol Biol202642793211PubTator, text miningPubMed
Non-canonical signaling hubs upon inhibition of MyD88-ERK interaction in cancer.Cell Death Dis202642791244PubTator, text miningPubMed
The E3 ubiquitin ligase HECTD3 controls immune colonic inflammation by restricting MyD88 activation and signaling.JCI Insight202642784256PubTator, text miningPubMed
Canakinumab or emavusertib for anemia in lower-risk MDS: results of the CANFIRE and LUCAS phase 2, open-label, multicenter trials.Commun Med (Lond)202642749863PubTator, text miningPubMed
Local ancestry inference identifies robust evidence of selection in Neolithic Europe.Mol Biol Evol202642749287PubTator, text miningPubMed
A possible founder IRAK4 variant in Okinawa, Japan.J Hum Immun202642742462PubTator, text miningPubMed
Discovery of JH-XIII-05-01, a First-in-Class Dual IRAK1/IRAK4 Degrader for MYD88 Mutant Lymphomas.ACS Med Chem Lett202642741641PubTator, text miningPubMed
Structural optimization of 2-(2-aminopyridin-4-yl)-N-(3-carbamoyl-1H-pyrazol-4-yl)-1,3-oxazole-4-carboxamide derivatives as potent interleukin-1 receptor-associated kinase 4 inhibitors.Bioorg Med Chem202642735465PubTator, text miningPubMed
CFTR regulates lipid metabolism by relieving adipose inflammation in obesity.Int J Obes (Lond)202642668310PubTator, text miningPubMed

1 to 10 of 3,419

See all 3,419 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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