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LEF1: lymphoid enhancer binding factor 1

1 protein, 68 patents, 0 drugs, 0 trials, 5,301 NIH grants and 8,441 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolLEF1HGNC
Namelymphoid enhancer binding factor 1HGNC
NCBI Gene ID51176NCBI Gene
HGNC IDHGNC:6551HGNC
EnsemblENSG00000138795NCBI Gene
AliasesECTD1, ECTD17, LEF-1, TCF10, TCF1ALPHA, TCF7L3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9UJU2Lymphoid enhancer-binding factor 13990Ensembl, GeneID, HGNCUniProt

Patents 68

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-292034Q9UJU2Espacenet
JP 2025147176 A2025-10-0615236Q9UJU2Espacenet
JP 2025517969 A2025-06-122034Q9UJU2Espacenet
JP 2025028160 A2025-02-2815236Q9UJU2Espacenet
KR 1020250010750 A2025-01-2115236Q9UJU2Espacenet
JP 2024123008 A2024-09-106844Q9UJU2Espacenet
JP 2024109657 A2024-08-1415075Q9UJU2Espacenet
US 11884978 B22024-01-30573Q9UJU2Espacenet
US 11446398 B22022-09-2047593Q9UJU2Espacenet
JP 2022524081 A2022-04-27150564Q9UJU2Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 5301

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant552,025NIH's project files
P30CA008748Cancer Center Support Grant512,025NIH's project files
P30CA062203Cancer Center Support Grant272,025NIH's project files
P30CA086862Cancer Center Support Grant192,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)182,025NIH's project files
P30CA068485Cancer Center Support Grant152,025NIH's project files
R01AI112579Regulation of T cell exhaustion via 3D chromatin architecture152,025NIH's project files
R01AR031737Regulation of Epidermal Development and Differentiation-Renewal152,025NIH's project files
P30DK054759Precision Medicine Center for Cystic Fibrosis142,025NIH's project files
R01AI121080CTCF in CD8 T cell homeostasis and anti-viral/tumor immunity132,025NIH's project files

Papers 8441

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818321PubTator, text miningPubMed
42790426PubTator, text miningPubMed
42765973PubTator, text miningPubMed
42745872PubTator, text miningPubMed
42715545PubTator, text miningPubMed
42650137PubTator, text miningPubMed
42615802PubTator, text miningPubMed
42586446PubTator, text miningPubMed
42547554PubTator, text miningPubMed
42529928PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license