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Gene · 51185

CRBN: cereblon

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CRBN: cereblon. Genes, record 51185. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51185

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Gene

Symbol
CRBN
HGNC
Name
cereblon
HGNC
NCBI Gene ID
51185
NCBI Gene
HGNC ID
HGNC:30185
HGNC
Ensembl
ENSG00000113851
NCBI Gene
Aliases
MRT2, MRT2A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96SW2Protein cereblon44298Ensembl, GeneID, HGNC

Source UniProt

Patents63

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026523243 A2026-07-13127Q96SW2Espacenet
JP 2026516229 A2026-05-20127Q96SW2Espacenet
EP 4705323 A12026-03-11127Q96SW2Espacenet
JP 2026004568 A2026-01-1440919Q96SW2Espacenet
WO 2025244125 A2025-11-2723Q96SW2Espacenet
EP 4650780 A22025-11-19820Q96SW2Espacenet
EP 4641201 A22025-10-29582Q96SW2Espacenet
JP 2025517969 A2025-06-12582Q96SW2Espacenet
JP 2025517970 A2025-06-12820Q96SW2Espacenet
WO 2025068704 A12025-04-031Q96SW2Espacenet

1 to 10 of 63

See all 63 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
IBERDOMIDECHEMBL3989927CRL4(CRBN) E3 ubiquitin ligase modulatorMODULATORChEMBL
LENALIDOMIDECHEMBL848CRL4(CRBN) E3 ubiquitin ligase inhibitorINHIBITORChEMBL
LENALIDOMIDECHEMBL848CRL4(CRBN) E3 ubiquitin ligase modulatorMODULATORChEMBL
LENALIDOMIDE HYDROCHLORIDE MONOHYDRATECHEMBL6068337CRL4(CRBN) E3 ubiquitin ligase modulatorMODULATORChEMBL
POMALIDOMIDECHEMBL43452CRL4(CRBN) E3 ubiquitin ligase inhibitorINHIBITORChEMBL
THALIDOMIDECHEMBL468CRL4(CRBN) E3 ubiquitin ligase inhibitorINHIBITORChEMBL

Trials1,695

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416LENALIDOMIDEPHASE2ClinicalTrials.gov
NCT07601100IBERDOMIDEPHASE1/PHASE2ClinicalTrials.gov
NCT07600151LENALIDOMIDEPHASE1/PHASE2ClinicalTrials.gov
NCT07585747LENALIDOMIDEPHASE2ClinicalTrials.gov
NCT07569757POMALIDOMIDEPHASE3ClinicalTrials.gov
NCT07562022LENALIDOMIDEPHASE3ClinicalTrials.gov
NCT07555938POMALIDOMIDEPHASE3ClinicalTrials.gov
NCT07532525POMALIDOMIDEPHASE1ClinicalTrials.gov
NCT07523737POMALIDOMIDEPHASE2ClinicalTrials.gov
NCT07505849LENALIDOMIDEPHASE2ClinicalTrials.gov

1 to 10 of 1,695

See all 1,695 trials

NIH grants1,407

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCRBN papersNewest fiscal year
R01CA214608The molecular basis of IMiD induced neo-substrate recruitment to the CRL4CRBN ubiquitin E3 ligase282025
P30CA008748Cancer Center Support Grant272025
R35CA197589Inducing Proximity: An Emerging Paradigm for New Therapeutic Modalities272025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias252025
P50CA186781Mayo Clinic Multiple Myeloma SPORE252025
P30CA016672Cancer Center Support Grant242025
R01CA218278Degrading therapeutically important kinases using small molecules202025
P01CA155258Integrative Oncogenomics of Multiple Myeloma152025
R01CA240981Harnessing E3 Ligases for Cancer Therapy142025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant112025

1 to 10 of 1,407Source NIH's project files

See all 1,407 nih grants

Papers2,935

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PROTAC probe-assisted degradomics identifies SPINT2 as a candidate cellular target involved in the anti-cancer activity of Flupentixol.Bioorg Chem202642826660PubTator, text miningPubMed
A scalable, high-throughput glue perturbation screening platform for molecular glue discovery.iScience202642824958PubTator, text miningPubMed
Beyond Immunomodulatory Drugs: Next-Generation Cereblon Modulators in Multiple Myeloma.Cancer J202642809693PubTator, text miningPubMed
Optimizing CRBN-ligands for optical targeted protein degradation.RSC Med Chem202642807851PubTator, text miningPubMed
Bridging E3 Ligase Binding and Targeted Degradation Through Fluorescence Polarization.Int J Mol Sci202642794484PubTator, text miningPubMed
Design, synthesis and biological evaluation of a series of new, potent FLT3 PROTAC degraders with rigid linkers.Bioorg Med Chem202642772077PubTator, text miningPubMed
Molecular glues: Recent advances in cereblon substrate identification and mechanistic insights.Smart Mol202642770064PubTator, text miningPubMed
PARP1-targeting PROTAC attenuates alcohol-associated liver injury and ileal epithelial damage.Biochem Pharmacol202642753829PubTator, text miningPubMed
Design, Synthesis, Biological Studies and Putative Binding Mode of Novel Benzotriazolothalidomide Derivatives as Cereblon Ligands.Chem Biol Drug Des202642740472PubTator, text miningPubMed
Expanding the E3 Ligase Landscape: From Small Molecule to Biological Targeted Protein Degradation.Handb Exp Pharmacol202642730806PubTator, text miningPubMed

1 to 10 of 2,935

See all 2,935 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/51185

GET https://conductscience.org/api/genes/v1/51185/patents?page=2