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Gene · 51192

CKLF: chemokine like factor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CKLF: chemokine like factor. Genes, record 51192. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51192

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Gene

Symbol
CKLF
HGNC
Name
chemokine like factor
HGNC
NCBI Gene ID
51192
NCBI Gene
HGNC ID
HGNC:13253
HGNC
Ensembl
ENSG00000217555
NCBI Gene
Aliases
C32, CKLF1, CKLF2, CKLF3, CKLF4, HSPC224, UCK-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UBR5Chemokine-like factor1520Ensembl, GeneID, HGNC

Source UniProt

Patents112

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192282Q9UBR5Espacenet
JP 2025147176 A2025-10-062933Q9UBR5Espacenet
JP 2025138725 A2025-09-251927Q9UBR5Espacenet
JP 2025529142 A2025-09-04958Q9UBR5Espacenet
JP 2025529142 A2025-09-045888Q9UBR5Espacenet
US 12371689 B22025-07-295888Q9UBR5Espacenet
US 12371689 B22025-07-29958Q9UBR5Espacenet
JP 2025517970 A2025-06-122282Q9UBR5Espacenet
JP 2025028160 A2025-02-282933Q9UBR5Espacenet
KR 1020250010750 A2025-01-212933Q9UBR5Espacenet

1 to 10 of 112

See all 112 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants460

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCKLF papersNewest fiscal year
R01AI049313T cell responses to CD1-restricted lipids in tuberculosis62025
P30CA013330Cancer Center Support Grant22025
P30CA016672Cancer Center Support Grant22025
P30CA046934University of Colorado Cancer Center Support Grant22025
P30DK052574Host-environment interactions in the pathophysiology of digestive disease22025
R01AI045889Precision Targeting of CD1-Restricted iNKT Cells for Cancer Immunotherapy22025
T32AI007306Immunologic Basis of Resistance and Hypersensitivity22025
I01BX002348Cellular and Molecular Mechanisms of Renal Anemia12025
K12EY016335Harvard-Vision Clinical Scientist Development Program12025
P20GM103423The Maine Biomedical Research Network (INBRE)12025

1 to 10 of 460Source NIH's project files

See all 460 nih grants

Papers1,450

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CMTM6/PD-L1-targeted AAV promotes anti-tumor immune responses and chemotherapy responsiveness.Front Immunol202642807306PubTator, text miningPubMed
Pharmacology-Informed Human Genetic Evaluation of Panax notoginseng Saponin-Related Candidate Genes for Functional Outcome After Ischemic Stroke Using Mendelian Randomization and Colocalization.Genes (Basel)202642793049PubTator, text miningPubMed
Self-Efficacy and Knowledge in Cardiotoxicity Management Among Pediatric Oncology Nurses: A Cross-Sectional Mediation Analysis.J Pediatr Hematol Oncol202642766532PubTator, text miningPubMed
Erratum to "Ginsenoside Rg1 alleviates post-ischemic stroke neuroinflammation by inhibiting CKLF1-mediated suppression of dead/dying neuron clearance" [Acta Pharmaceutica Sinica B 16 (2026) 3632-3654].
Acta Pharm Sin B202642764893PubTator, text miningPubMed
Role of CMTM6 in disease pathogenesis and clinical translation potential (Review).Mol Med Rep202642535376PubTator, text miningPubMed
Multi-omics analysis identifies CKLF as a promoter for HCC progression by regulating the AKT, ERK pathways, and infiltrating immune cells.Transl Oncol202642241992PubTator, text miningPubMed
CKLF-like MARVEL transmembrane domain-containing superfamily 8 (CMTM8) promotes Notch signalling to maintain CD8+ T cell- and NK cell-dependent tumour immune escape.Br J Pharmacol202642219547PubTator, text miningPubMed
A neutrophil-intrinsic CKLF1-PKM2 axis drives glycolytic flux for de novo DAG synthesis and pro-inflammatory ROS production.Cell Death Differ202642120940PubTator, text miningPubMed
Mistranslation from an endogenous tRNA variant in human pan-genome cell lines.Nucleic Acids Res202641841496PubTator, text miningPubMed
DNA secondary structures in BCL2 and MYC elicit activation-induced cytidine deaminase binding and activity.Nucleic Acids Res202641830329PubTator, text miningPubMed

1 to 10 of 1,450

See all 1,450 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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