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Gene · 51196

PLCE1: phospholipase C epsilon 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PLCE1: phospholipase C epsilon 1. Genes, record 51196. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51196

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Gene

Symbol
PLCE1
HGNC
Name
phospholipase C epsilon 1
HGNC
NCBI Gene ID
51196
NCBI Gene
HGNC ID
HGNC:17175
HGNC
Ensembl
ENSG00000138193
NCBI Gene
Aliases
KIAA1516, NPHS3, PLCE, PPLC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9P2121-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-12,3023Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457920Q9P212Espacenet
EP 4650780 A22025-11-198935Q9P212Espacenet
EP 4640849 A22025-10-291344Q9P212Espacenet
EP 4641201 A22025-10-299192Q9P212Espacenet
JP 2025519096 A2025-06-241344Q9P212Espacenet
JP 2025517969 A2025-06-129192Q9P212Espacenet
JP 2025517970 A2025-06-128935Q9P212Espacenet
JP 2025032204 A2025-03-1133581Q9P212Espacenet
EP 4461818 A22024-11-1333581Q9P212Espacenet
JP 2023058610 A2023-04-2533581Q9P212Espacenet

1 to 10 of 21

See all 21 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,925

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePLCE1 papersNewest fiscal year
P30ES010126UNC Center for Environmental Health and Susceptibility52025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal52025
P30CA016672Cancer Center Support Grant42025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
P30EY014104P30 Core Grant for Vision Research42025
R01EY022305NEIGHBORHOOD Consortium for POAG Genetics42025
P30CA008748Cancer Center Support Grant32025
P30DK056350Nutrition Obesity Research Center (NORC)32025
P30DK063491Diabetes Research Center (DRC)32025
R01AI027655How Listeria senses and responds to different host environments32025

1 to 10 of 1,925Source NIH's project files

See all 1,925 nih grants

Papers2,548

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cholinergic activation of HLH-30/TFEB promotes C. elegans infection resilience.bioRxiv202642818098PubTator, text miningPubMed
Retraction notice to "MiR-328 suppresses the survival of esophageal cancer cells by targeting PLCE1" [Biochem. Biophys. Res. Commun. 470, (2016), 175-180].Biochem Biophys Res Commun202642816240PubTator, text miningPubMed
Genome-wide association susceptibility loci for cluster headache support a role for inflammation in the pathophysiology.J Headache Pain202642557554PubTator, text miningPubMed
Over-induction of innate immune responses suppresses T cell response to mRNA SARS-CoV-2 vaccination.Vaccine202642531983PubTator, text miningPubMed
Development and internal validation of a risk prediction model for gastric precancerous lesions integrating Helicobacter pylori serologic typing and host susceptibility polymorphisms.Medicine (Baltimore)202642410859PubTator, text miningPubMed
Arsenic induced deubiquitination modification of PLCE1 in a de-SUMO-dependent manner to affect malignant behavior in bladder epithelial cells.J Hazard Mater202642335809PubTator, text miningPubMed
PLCε regulates podocyte differentiation and TGF-β1 responses via alteration of SMAD2/SMAD3 ratio.Cell Commun Signal202642129791PubTator, text miningPubMed
Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.Eur Heart J202642036355PubTator, text miningPubMed
Gap Analysis of Metabolic Conversions of Off-Flavors and Antinutrients in Plant-Based Substrates.Compr Rev Food Sci Food Saf202641918190PubTator, text miningPubMed
Influence of age and diet on the expression of microRNAs in coronary heart disease: Findings from the CORDIOPREV study.Maturitas202641849882PubTator, text miningPubMed

1 to 10 of 2,548

See all 2,548 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/51196

GET https://conductscience.org/api/genes/v1/51196/patents?page=2