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Gene · 51206

GP6: glycoprotein VI platelet

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GP6: glycoprotein VI platelet. Genes, record 51206. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51206

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Gene

Symbol
GP6
HGNC
Name
glycoprotein VI platelet
HGNC
NCBI Gene ID
51206
NCBI Gene
HGNC ID
HGNC:14388
HGNC
Ensembl
ENSG00000088053
NCBI Gene
Aliases
BDPLT11, GPIV, GPVI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9HCN6Platelet glycoprotein VI3396Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448057Q9HCN6Espacenet
JP 2025147176 A2025-10-066120Q9HCN6Espacenet
JP 2025529142 A2025-09-041758Q9HCN6Espacenet
JP 2025529142 A2025-09-046525Q9HCN6Espacenet
US 12371689 B22025-07-291758Q9HCN6Espacenet
US 12371689 B22025-07-296525Q9HCN6Espacenet
JP 2025028160 A2025-02-286120Q9HCN6Espacenet
KR 1020250010750 A2025-01-216120Q9HCN6Espacenet
JP 2024109657 A2024-08-146127Q9HCN6Espacenet
US 11446398 B22022-09-2035696Q9HCN6Espacenet

1 to 10 of 25

See all 25 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
GLENZOCIMABCHEMBL4650395Platelet glycoprotein VI (GPVI) inhibitorINHIBITOR

Source ChEMBL

Trials5

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06437431GLENZOCIMABPHASE2/PHASE3ClinicalTrials.gov
NCT05559398GLENZOCIMABPHASE2/PHASE3ClinicalTrials.gov
NCT05070260GLENZOCIMABPHASE2/PHASE3ClinicalTrials.gov
NCT04659109GLENZOCIMABPHASE2ClinicalTrials.gov
NCT03803007GLENZOCIMABPHASE1/PHASE2ClinicalTrials.gov

NIH grants1,402

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGP6 papersNewest fiscal year
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI282025
P30CA016672Cancer Center Support Grant102025
P51OD011092Support for National Primate Research Center82025
P30CA069533OHSU Knight Cancer Institute72025
P30EY010572Ophthalmology Core Facility52025
R01HL144113Contact Pathway Activation on Vascular Devices52025
ZIAHL006170Cardiovascular Genomics and Bioinformatics projects52025
R01HL162940Computational Modeling of Device-Induced Platelet Activation and Receptor Shedding Relevant to Thrombosis and Bleeding in Device-Assisted Circulation42025
P30CA008748Cancer Center Support Grant32025
P30CA030199Cancer Center Support Grant (CCSG)32025

1 to 10 of 1,402Source NIH's project files

See all 1,402 nih grants

Papers3,850

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Inhibition of mitochondrial permeability transition selectively suppresses thrombogenic platelet procoagulant activity.Blood202642821743PubTator, text miningPubMed
A Boolean Seven-Layer Platelet Decision Model Models Consistently the Logic and Semiquantitatively the Dynamics of Platelet Activation and Inhibition.Comput Struct Biotechnol J202642819776PubTator, text miningPubMed
Circulating Proteins as Predictors of Improvement in Physical Function in Hospitalized Older Adults with Geriatric Syndromes: Findings from the REHAB-HF Trial.medRxiv202642818424PubTator, text miningPubMed
Differential inhibition of bispecific GPVI and CLEC-2 nanobody ligands by a monovalent nanobody.Thromb Res202642805106PubTator, text miningPubMed
Platelet glycoprotein VI in platelet-neutrophil interactions: From complex formation to neutrophil extracellular trap-associated pathology.Int Immunopharmacol202642763243PubTator, text miningPubMed
Study of centrifugal blood pump non-physiological shear stress induced platelet hemostatic dysfunction.Thromb Res202642743859PubTator, text miningPubMed
Platelets mediate fibrin-induced thromboinflammation and NETosis through a GPVI-polyphosphate-FXIIa procoagulant axis.Blood Vessel Thromb Hemost202642729624PubTator, text miningPubMed
Construction of molecular signatures based on the co-expression network of NECSO-related gene TRPM4 and its prognostic value in hepatocellular carcinoma.J Gastrointest Oncol202642703320PubTator, text miningPubMed
Predicting Device-Induced Platelet Damage in Assisted Circulation Using a New Biophysical Model and Experimental Validation.Artif Organs202642698235PubTator, text miningPubMed
Comparative analysis of human papilloma virus detection methods and prognostic significance of transcriptionally active viral load in oropharyngeal squamous cell carcinoma.Oral Oncol202642696859PubTator, text miningPubMed

1 to 10 of 3,850

See all 3,850 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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