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PCSK1: proprotein convertase subtilisin/kexin type 1

1 protein, 93 patents, 0 drugs, 0 trials, 4,705 NIH grants and 7,634 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPCSK1HGNC
Nameproprotein convertase subtilisin/kexin type 1HGNC
NCBI Gene ID5122NCBI Gene
HGNC IDHGNC:8743HGNC
EnsemblENSG00000175426NCBI Gene
AliasesBMIQ12, NEC1, PC1, PC1/3, PC3, SPC3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P29120Neuroendocrine convertase 17533Ensembl, GeneID, HGNCUniProt

Patents 93

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11567P29120Espacenet
JP 2026004568 A2026-01-1459359P29120Espacenet
EP 4650780 A22025-11-194536P29120Espacenet
EP 4640849 A22025-10-29605P29120Espacenet
EP 4641201 A22025-10-294093P29120Espacenet
JP 2025147176 A2025-10-0610116P29120Espacenet
JP 2025529142 A2025-09-047290P29120Espacenet
US 12371689 B22025-07-297290P29120Espacenet
JP 2025519096 A2025-06-24605P29120Espacenet
JP 2025517969 A2025-06-124093P29120Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 4705

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK020595Diabetes Research and Training Center152,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant132,025NIH's project files
P30DK063491Diabetes Research Center (DRC)132,025NIH's project files
P30CA008748Cancer Center Support Grant122,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)122,025NIH's project files
P30DK020541NYR-Diabetes Research Center (NYR-DRC)92,025NIH's project files
P30ES009089Center for Environmental Health in Northern Manhattan92,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility92,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award92,025NIH's project files
P30CA014236Cancer Center Support Grant (CCSG)82,025NIH's project files

Papers 7634

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821293PubTator, text miningPubMed
42814551PubTator, text miningPubMed
42812380PubTator, text miningPubMed
42810039PubTator, text miningPubMed
42794351PubTator, text miningPubMed
42792527PubTator, text miningPubMed
42791368PubTator, text miningPubMed
42783415PubTator, text miningPubMed
42781559PubTator, text miningPubMed
42776329PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license