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Gene · 5125

PCSK5: proprotein convertase subtilisin/kexin type 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PCSK5: proprotein convertase subtilisin/kexin type 5. Genes, record 5125. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5125

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Gene

Symbol
PCSK5
HGNC
Name
proprotein convertase subtilisin/kexin type 5
HGNC
NCBI Gene ID
5125
NCBI Gene
HGNC ID
HGNC:8747
HGNC
Ensembl
ENSG00000099139
NCBI Gene
Aliases
PC5, PC6, PC6A, SPC6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92824Proprotein convertase subtilisin/kexin type 51,8600Ensembl, GeneID, HGNC

Source UniProt

Patents53

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11572Q92824Espacenet
JP 2026004568 A2026-01-1459374Q92824Espacenet
EP 4650780 A22025-11-1916432Q92824Espacenet
EP 4641201 A22025-10-2920220Q92824Espacenet
EP 4641202 A22025-10-291151Q92824Espacenet
EP 4641203 A22025-10-29635Q92824Espacenet
JP 2025147176 A2025-10-0610128Q92824Espacenet
JP 2025529142 A2025-09-043423Q92824Espacenet
JP 2025529142 A2025-09-047294Q92824Espacenet
US 12371689 B22025-07-293423Q92824Espacenet

1 to 10 of 53

See all 53 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,355

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePCSK5 papersNewest fiscal year
P30CA008748Cancer Center Support Grant62025
P30CA006927Comprehensive Cancer Center Program at Fox Chase52025
P30DK020595Diabetes Research and Training Center52025
P30CA021765Cancer Center Support Grant (CCSG)32025
P30DK020572Michigan Diabetes Research Center (MDRC)32025
P30DK063491Diabetes Research Center (DRC)32025
ZIABC009052Understanding Papillomavirus Virion Proteins and Vaccines32025
K24AR072133Mentoring Biomechanics Research in Osteoarthritis22025
P20GM103408Idaho INBRE Program22025
P30AG072975Rush Alzheimer's Disease Research Center22025

1 to 10 of 1,355Source NIH's project files

See all 1,355 nih grants

Papers2,220

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Epigenome-wide profiling identifies distinct DNA methylation architecture underlying ME/CFS and fibromyalgia symptom burden.J Transl Med202642811334PubTator, text miningPubMed
Identification of cognitive factors that predict behavioural weight-loss intervention outcomes.Int J Obes (Lond)202642668311PubTator, text miningPubMed
The interplay of air pollution with plasma neurodegenerative markers and metabolome for dementia, Parkinson's disease and all-cause mortality risks and transitions: The UK Biobank study.Ecotoxicol Environ Saf202642632170PubTator, text miningPubMed
Intrapartum Acupuncture Provision in the UK: A Survey of Independent Acupuncture Practitioners.Healthcare (Basel)202642588292PubTator, text miningPubMed
Whole exome sequencing uncovers novel genetic insights into Tethered cord syndrome.Mol Genet Genomics202642566055PubTator, text miningPubMed
PCSK5 promotes angiogenesis and cardiac repair after myocardial infarction.Nat Commun202642399637PubTator, text miningPubMed
Effect and safety of Neiguan acupoint injection with astragalus injection for chronic heart failure with qi-deficiency and blood-stasis syndrome: a randomized controlled trial.Front Med (Lausanne)202642292177PubTator, text miningPubMed
Identification and validation of a Golgi apparatus related gene signature for prognosis prediction and immune microenvironment profiling in colorectal cancer.Discov Oncol202642105160PubTator, text miningPubMed
Most Useful Acupuncture Points (MUAPs) Teaching Cluster: A Structured Narrative Review of Mechanistic Evidence for Biomedical Acupuncture Training.Cureus202642099340PubTator, text miningPubMed
Quantifying direct genetic signal captured by principal component adjustment.Proc Natl Acad Sci U S A202642060716PubTator, text miningPubMed

1 to 10 of 2,220

See all 2,220 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5125

GET https://conductscience.org/api/genes/v1/5125/patents?page=2