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TLR7: toll like receptor 7

1 protein, 331 patents, 12 drugs, 437 trials, 8,124 NIH grants and 17,143 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTLR7HGNC
Nametoll like receptor 7HGNC
NCBI Gene ID51284NCBI Gene
HGNC IDHGNC:15631HGNC
EnsemblENSG00000196664NCBI Gene
AliasesIMD74, SLEB17, TLR7-likeNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9NYK1Toll-like receptor 71,0491Ensembl, GeneID, HGNCUniProt

Patents 331

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4777520 A12026-07-226Q9NYK1Espacenet
JP 2026016483 A2026-02-032Q9NYK1Espacenet
JP 2026004568 A2026-01-1467232Q9NYK1Espacenet
EP 4650780 A22025-11-1910348Q9NYK1Espacenet
EP 4641201 A22025-10-2910670Q9NYK1Espacenet
JP 2025529142 A2025-09-044685Q9NYK1Espacenet
US 12371689 B22025-07-294685Q9NYK1Espacenet
US 12365711 B22025-07-2222Q9NYK1Espacenet
JP 2025517969 A2025-06-1210670Q9NYK1Espacenet
JP 2025517970 A2025-06-1210348Q9NYK1Espacenet

Drugs 12

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AFIMETORANCHEMBL4650329Toll-like receptor 7 inhibitorINHIBITORChEMBL
AZD-8848CHEMBL4297356Toll-like receptor 7 agonistAGONISTChEMBL
BAZLITORANCHEMBL4297995Toll-like receptor 7 antagonistANTAGONISTChEMBL
CPG-52852CHEMBL549344Toll-like receptor 7 agonistAGONISTChEMBL
ENPATORANCHEMBL4802159Toll-like receptor 7 antagonistANTAGONISTChEMBL
GSK-2245035CHEMBL4297492Toll-like receptor 7 agonistAGONISTChEMBL
HYDROXYCHLOROQUINECHEMBL1535Toll-like receptor 7 antagonistANTAGONISTChEMBL
HYDROXYCHLOROQUINE SULFATECHEMBL1690Toll-like receptor 7 antagonistANTAGONISTChEMBL
IMIQUIMODCHEMBL1282Toll-like receptor 7 agonistAGONISTChEMBL
RESIQUIMODCHEMBL383322Toll-like receptor 7 agonistAGONISTChEMBL

Trials 437

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07467252HYDROXYCHLOROQUINEPHASE2ClinicalTrials.gov
NCT07443436HYDROXYCHLOROQUINEPHASE2ClinicalTrials.gov
NCT07355218ENPATORANPHASE3ClinicalTrials.gov
NCT07332481ENPATORANPHASE3ClinicalTrials.gov
NCT07265297HYDROXYCHLOROQUINEPHASE3ClinicalTrials.gov
NCT07251413IMIQUIMODPHASE1/PHASE2ClinicalTrials.gov
NCT07210775IMIQUIMODPHASE1/PHASE2ClinicalTrials.gov
NCT07190534HYDROXYCHLOROQUINEClinicalTrials.gov
NCT07061717HYDROXYCHLOROQUINEPHASE3ClinicalTrials.gov
NCT07013110HYDROXYCHLOROQUINEPHASE2ClinicalTrials.gov

NIH grants 8124

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success322,025NIH's project files
P30CA016672Cancer Center Support Grant302,025NIH's project files
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged282,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award262,025NIH's project files
P30CA008748Cancer Center Support Grant242,025NIH's project files
P51OD011132Emory National Primate Research Center232,025NIH's project files
P30AI050409Center for AIDS Research at Emory University182,025NIH's project files
R01AI163029Inborn errors of immunity in patients with life-threatening COVID-19182,025NIH's project files
U54GM104938Oklahoma Shared Clinical and Translational Resources182,025NIH's project files
R01AI072429Regulation of TLR trafficking for proper self versus non-self discrimination162,025NIH's project files

Papers 17143

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827395PubTator, text miningPubMed
42827008PubTator, text miningPubMed
42825403PubTator, text miningPubMed
42811768PubTator, text miningPubMed
42808586PubTator, text miningPubMed
42792959PubTator, text miningPubMed
42787611PubTator, text miningPubMed
42781103PubTator, text miningPubMed
42763984PubTator, text miningPubMed
42741301PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license