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TLR8: toll like receptor 8

1 protein, 87 patents, 7 drugs, 42 trials, 4,513 NIH grants and 8,542 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTLR8HGNC
Nametoll like receptor 8HGNC
NCBI Gene ID51311NCBI Gene
HGNC IDHGNC:15632HGNC
EnsemblENSG00000101916NCBI Gene
AliasesCD288, IMD98, TLR-8, hTLR8NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9NR97Toll-like receptor 81,04139Ensembl, GeneID, HGNCUniProt

Patents 87

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467233Q9NR97Espacenet
WO 2025252547 A12025-12-11153Q9NR97Espacenet
EP 4660322 A12025-12-10153Q9NR97Espacenet
EP 4650780 A22025-11-19410Q9NR97Espacenet
JP 2025529142 A2025-09-044686Q9NR97Espacenet
US 12371689 B22025-07-294686Q9NR97Espacenet
US 12365711 B22025-07-2223Q9NR97Espacenet
JP 2025517970 A2025-06-12410Q9NR97Espacenet
US 12274744 B22025-04-15282Q9NR97Espacenet
JP 2025061659 A2025-04-1123Q9NR97Espacenet

Drugs 7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AFIMETORANCHEMBL4650329Toll-like receptor 8 inhibitorINHIBITORChEMBL
BAZLITORANCHEMBL4297995Toll-like receptor 8 antagonistANTAGONISTChEMBL
ENPATORANCHEMBL4802159Toll-like receptor 8 antagonistANTAGONISTChEMBL
MOTOLIMODCHEMBL3301618Toll-like receptor 8 agonistAGONISTChEMBL
RESIQUIMODCHEMBL383322Toll-like receptor 8 agonistAGONISTChEMBL
SELGANTOLIMODCHEMBL4594258Toll-like receptor 8 agonistAGONISTChEMBL
TELRATOLIMODCHEMBL4297631Toll-like receptor 8 agonistAGONISTChEMBL

Trials 42

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07355218ENPATORANPHASE3ClinicalTrials.gov
NCT07332481ENPATORANPHASE3ClinicalTrials.gov
NCT05650567ENPATORANPHASE2ClinicalTrials.gov
NCT05551273SELGANTOLIMODPHASE2ClinicalTrials.gov
NCT05540327ENPATORANPHASE2ClinicalTrials.gov
NCT05162586ENPATORANPHASE22025-12-01ClinicalTrials.gov
NCT05045261SELGANTOLIMODPHASE2ClinicalTrials.gov
NCT04895696AFIMETORANPHASE2ClinicalTrials.gov
NCT04891770SELGANTOLIMODPHASE22025-07-24ClinicalTrials.gov
NCT04647708ENPATORANPHASE1ClinicalTrials.gov

NIH grants 4513

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant172,025NIH's project files
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success152,025NIH's project files
P30CA016058Cancer Center Support Grant132,025NIH's project files
U19AI089992Immune signatures of vaccine responses in vulnerable populations132,025NIH's project files
P30CA008748Cancer Center Support Grant112,025NIH's project files
P30CA047904Cancer Center Support Grant112,025NIH's project files
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged112,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award102,025NIH's project files
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)92,025NIH's project files
P30CA016087Cancer Center Support Grant92,025NIH's project files

Papers 8542

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827395PubTator, text miningPubMed
42824315PubTator, text miningPubMed
42812615PubTator, text miningPubMed
42794434PubTator, text miningPubMed
42792959PubTator, text miningPubMed
42782216PubTator, text miningPubMed
42743356PubTator, text miningPubMed
42741301PubTator, text miningPubMed
42720504PubTator, text miningPubMed
42688675PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license