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PDCD1: programmed cell death 1

1 protein, 1,127 patents, 26 drugs, 6,986 trials, 14,918 NIH grants and 87,595 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPDCD1HGNC
Nameprogrammed cell death 1HGNC
NCBI Gene ID5133NCBI Gene
HGNC IDHGNC:8760HGNC
EnsemblENSG00000188389NCBI Gene
AliasesADMIO4, AIMTBS, CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q15116Programmed cell death protein 128838Ensembl, GeneID, HGNCUniProt

Patents 1127

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4831196 A22026-10-2810Q15116Espacenet
WO 2026219939 A12026-10-2249Q15116Espacenet
WO 2026215173 A12026-10-1549Q15116Espacenet
WO 2026215363 A12026-10-1549Q15116Espacenet
WO 2026215526 A12026-10-1549Q15116Espacenet
WO 2026189672 A12026-09-17174Q15116Espacenet
WO 2026190350 A12026-09-17174Q15116Espacenet
EP 4806462 A22026-09-1633Q15116Espacenet
EP 4795063 A12026-08-2616Q15116Espacenet
EP 4796121 A22026-08-2633Q15116Espacenet

Drugs 26

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APL-501CHEMBL4594355Programmed cell death protein 1 inhibitorINHIBITORChEMBL
BALSTILIMABCHEMBL4297877Programmed cell death protein 1 antagonistANTAGONISTChEMBL
BUDIGALIMABCHEMBL4297858Programmed cell death protein 1 inhibitorINHIBITORChEMBL
CADONILIMABCHEMBL4594456Programmed cell death protein 1 inhibitorINHIBITORChEMBL
CAMRELIZUMABCHEMBL4297715Programmed cell death protein 1 antagonistANTAGONISTChEMBL
CEMIPLIMABCHEMBL4297723Programmed cell death protein 1 inhibitorINHIBITORChEMBL
CETRELIMABCHEMBL4298001Programmed cell death protein 1 inhibitorINHIBITORChEMBL
CS-1003CHEMBL4594536Programmed cell death protein 1 inhibitorINHIBITORChEMBL
DOSTARLIMABCHEMBL4298124Programmed cell death protein 1 antagonistANTAGONISTChEMBL
FINOTONLIMABCHEMBL4650516Programmed cell death protein 1 inhibitorINHIBITORChEMBL

Trials 6986

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604909SERPLULIMABPHASE2ClinicalTrials.gov
NCT07603856NIVOLUMABPHASE2ClinicalTrials.gov
NCT07603856PEMBROLIZUMABPHASE2ClinicalTrials.gov
NCT07603856CEMIPLIMABPHASE2ClinicalTrials.gov
NCT07603661SINTILIMABPHASE2ClinicalTrials.gov
NCT07602907TORIPALIMABPHASE2ClinicalTrials.gov
NCT07602049CAMRELIZUMABPHASE2ClinicalTrials.gov
NCT07601737TISLELIZUMABPHASE2ClinicalTrials.gov
NCT07598318PUCOTENLIMABPHASE2/PHASE3ClinicalTrials.gov
NCT07596121SERPLULIMABPHASE2ClinicalTrials.gov

NIH grants 14918

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1,1402,025NIH's project files
P30CA016672Cancer Center Support Grant6482,025NIH's project files
P30CA006973Regional Oncology Research Center2382,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award2192,025NIH's project files
P30CA047904Cancer Center Support Grant1382,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant1162,025NIH's project files
P30CA016058Cancer Center Support Grant1062,025NIH's project files
P50CA101942DF/HCC Kidney Cancer SPORE (supplement)1022,025NIH's project files
P30CA016359Cancer Center Support Grant962,025NIH's project files
P30CA086862Cancer Center Support Grant962,025NIH's project files

Papers 87595

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827333PubTator, text miningPubMed
42827008PubTator, text miningPubMed
42826713PubTator, text miningPubMed
42826707PubTator, text miningPubMed
42826135PubTator, text miningPubMed
42826021PubTator, text miningPubMed
42824962PubTator, text miningPubMed
42824772PubTator, text miningPubMed
42824677PubTator, text miningPubMed
42824609PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license