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Gene · 51330

TNFRSF12A: TNF receptor superfamily member 12A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TNFRSF12A: TNF receptor superfamily member 12A. Genes, record 51330. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51330

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Gene

Symbol
TNFRSF12A
HGNC
Name
TNF receptor superfamily member 12A
HGNC
NCBI Gene ID
51330
NCBI Gene
HGNC ID
HGNC:18152
HGNC
Ensembl
ENSG00000006327
NCBI Gene
Aliases
CD266, FN14, TWEAKR, TweakR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NP84Tumor necrosis factor receptor superfamily member 12A1293Ensembl, GeneID, HGNC

Source UniProt

Patents210

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468654Q9NP84Espacenet
EP 4650780 A22025-11-195681Q9NP84Espacenet
EP 4628503 A22025-10-0830Q9NP84Espacenet
JP 2025147176 A2025-10-0613567Q9NP84Espacenet
JP 2025147176 A2025-10-0616536Q9NP84Espacenet
JP 2025529142 A2025-09-045000Q9NP84Espacenet
JP 2025529142 A2025-09-047937Q9NP84Espacenet
US 12371689 B22025-07-295000Q9NP84Espacenet
US 12371689 B22025-07-297937Q9NP84Espacenet
JP 2025517970 A2025-06-125681Q9NP84Espacenet

1 to 10 of 210

See all 210 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
ENAVATUZUMABCHEMBL1743011Tumor necrosis factor receptor superfamily member 12A agonistAGONIST

Source ChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,212

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTNFRSF12A papersNewest fiscal year
P30CA016672Cancer Center Support Grant82025
T32CA154274Training Grant in Cancer Biology72025
ZIABC011176Functions of KSHV microRNAs and circular RNAs72025
T32HL007698Interdisciplinary Training Program in Cardiovascular Disease62025
P30CA134274UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT52025
UL1TR001998Kentucky Center for Clinical and Translational Science52025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant42025
P30ES006694Southwest Environmental Health Sciences Center42025
P30CA006973Regional Oncology Research Center32025
P30CA023108Cancer Center Support Grant32025

1 to 10 of 1,212Source NIH's project files

See all 1,212 nih grants

Papers2,047

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Spatial transcriptomic analysis of progressing oral epithelial dysplasia reveals unique differentially expressed genes and microenvironmental changes.Mol Cancer Res202642808889PubTator, text miningPubMed
Protein Biomarkers in Risk and Prognosis of Amyotrophic Lateral Sclerosis.Eur J Neurol202642698373PubTator, text miningPubMed
CD266+ Myofibroblasts Mediate Resistance to Immunochemotherapy through ECM Stiffness in Head and Neck Squamous Cell Carcinoma.Cancer Immunol Res202642671928PubTator, text miningPubMed
Correction to: The TNFR superfamily member Fn14 impacts immunity and survival in experimental gliomas and response to immune checkpoint inhibitor therapy in glioblastoma patients.Neurooncol Adv202642662693PubTator, text miningPubMed
Construction and Validation of a Ubiquitination-Related Gene Signature Based on WGCNA and Single-cell RNA Sequencing in Bladder Cancer.Curr Med Chem202642576531PubTator, text miningPubMed
Identification of TNFRSF12A as a key regulator of stemness and immunosuppression in a novel glioma subtype via multi-omics analysis and experimental validation.Clin Immunol202642542235PubTator, text miningPubMed
Elevated FN14 expression promotes proliferation, chemoresistance, and impairment of differentiation in rhabdomyosarcoma.Cancer Lett202642521076PubTator, text miningPubMed
Single-cell transcriptome reveals keratinocyte subclusters contributing to altered differentiation and inflammatory responses in atopic dermatitis.Nat Commun202642449103PubTator, text miningPubMed
Preliminary effects of a four-month circuit training intervention on cognitive function and exploratory plasma proteomic profiles in middle-aged and older women: an open-label randomized controlled trial.
Front Sports Act Living202642416337PubTator, text miningPubMed
TWEAK/FN14 inhibition synergizes with oncogene-directed tyrosine kinase inhibitors to overcome resistance across multiple driver contexts.Sci Rep202642399307PubTator, text miningPubMed

1 to 10 of 2,047

See all 2,047 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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