Gene · 51330
TNFRSF12A: TNF receptor superfamily member 12A
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TNFRSF12A: TNF receptor superfamily member 12A. Genes, record 51330. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51330
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NP84 | Tumor necrosis factor receptor superfamily member 12A | 129 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents210
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 68654 | Q9NP84 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5681 | Q9NP84 | Espacenet |
| EP 4628503 A2 | 2025-10-08 | 30 | Q9NP84 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 13567 | Q9NP84 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 16536 | Q9NP84 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5000 | Q9NP84 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7937 | Q9NP84 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5000 | Q9NP84 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7937 | Q9NP84 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 5681 | Q9NP84 | Espacenet |
1 to 10 of 210
See all 210 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| ENAVATUZUMAB | CHEMBL1743011 | Tumor necrosis factor receptor superfamily member 12A agonist | AGONIST |
Source ChEMBL
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,212
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TNFRSF12A papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| T32CA154274 | Training Grant in Cancer Biology | 7 | 2025 |
| ZIABC011176 | Functions of KSHV microRNAs and circular RNAs | 7 | 2025 |
| T32HL007698 | Interdisciplinary Training Program in Cardiovascular Disease | 6 | 2025 |
| P30CA134274 | UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT | 5 | 2025 |
| UL1TR001998 | Kentucky Center for Clinical and Translational Science | 5 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 4 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 4 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 3 | 2025 |
| P30CA023108 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,212Source NIH's project files
See all 1,212 nih grantsPapers2,047
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Spatial transcriptomic analysis of progressing oral epithelial dysplasia reveals unique differentially expressed genes and microenvironmental changes. | Mol Cancer Res | 2026 | 42808889 | PubTator, text mining | PubMed |
| Protein Biomarkers in Risk and Prognosis of Amyotrophic Lateral Sclerosis. | Eur J Neurol | 2026 | 42698373 | PubTator, text mining | PubMed |
| CD266+ Myofibroblasts Mediate Resistance to Immunochemotherapy through ECM Stiffness in Head and Neck Squamous Cell Carcinoma. | Cancer Immunol Res | 2026 | 42671928 | PubTator, text mining | PubMed |
| Correction to: The TNFR superfamily member Fn14 impacts immunity and survival in experimental gliomas and response to immune checkpoint inhibitor therapy in glioblastoma patients. | Neurooncol Adv | 2026 | 42662693 | PubTator, text mining | PubMed |
| Construction and Validation of a Ubiquitination-Related Gene Signature Based on WGCNA and Single-cell RNA Sequencing in Bladder Cancer. | Curr Med Chem | 2026 | 42576531 | PubTator, text mining | PubMed |
| Identification of TNFRSF12A as a key regulator of stemness and immunosuppression in a novel glioma subtype via multi-omics analysis and experimental validation. | Clin Immunol | 2026 | 42542235 | PubTator, text mining | PubMed |
| Elevated FN14 expression promotes proliferation, chemoresistance, and impairment of differentiation in rhabdomyosarcoma. | Cancer Lett | 2026 | 42521076 | PubTator, text mining | PubMed |
| Single-cell transcriptome reveals keratinocyte subclusters contributing to altered differentiation and inflammatory responses in atopic dermatitis. | Nat Commun | 2026 | 42449103 | PubTator, text mining | PubMed |
Preliminary effects of a four-month circuit training intervention on cognitive function and exploratory plasma proteomic profiles in middle-aged and older women: an open-label randomized controlled trial. | Front Sports Act Living | 2026 | 42416337 | PubTator, text mining | PubMed |
| TWEAK/FN14 inhibition synergizes with oncogene-directed tyrosine kinase inhibitors to overcome resistance across multiple driver contexts. | Sci Rep | 2026 | 42399307 | PubTator, text mining | PubMed |
1 to 10 of 2,047
See all 2,047 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/51330
GET https://conductscience.org/api/genes/v1/51330/patents?page=2