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Gene · 51360

MBTPS2: membrane bound transcription factor peptidase, site 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MBTPS2: membrane bound transcription factor peptidase, site 2. Genes, record 51360. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51360

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Gene

Symbol
MBTPS2
HGNC
Name
membrane bound transcription factor peptidase, site 2
HGNC
NCBI Gene ID
51360
NCBI Gene
HGNC ID
HGNC:15455
HGNC
Ensembl
ENSG00000012174
NCBI Gene
Aliases
BRESEK, IFAP, KFSD, KFSDX, OI19, OLMSX, S2P
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43462Membrane-bound transcription factor site-2 protease5190Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026082974 A2026-05-19133O43462Espacenet
EP 4705273 A22026-03-11577O43462Espacenet
JP 2026004568 A2026-01-1453217O43462Espacenet
EP 4650780 A22025-11-1910170O43462Espacenet
JP 2025529142 A2025-09-042567O43462Espacenet
US 12371689 B22025-07-292567O43462Espacenet
JP 2025517970 A2025-06-1210170O43462Espacenet
JP 2025013347 A2025-01-24577O43462Espacenet
EP 4406585 A22024-07-31577O43462Espacenet
JP 2023011696 A2023-01-24577O43462Espacenet

1 to 10 of 36

See all 36 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants917

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMBTPS2 papersNewest fiscal year
ZIAAI005149Immunogen Design for SARS-CoV-2122025
P51OD011132Emory National Primate Research Center112025
UM1AI148373Kaiser Washington Vaccine and Treatment Evaluation Unit92025
UM1AI148576Vaccine and Treatment Evaluation Units92025
UM1AI148684Leadership Group for the Infectious Diseases Clinical Research Consortium (IDCRCLG)92025
ZIAAI005151Innate and Adaptive Immune Responses in SARS-CoV-2 infection (COVID-19)92025
ZIAAI005022Antibody Neutralization Mechanisms82025
ZIAAI005033Immune Responses To Human Pathogens72025
ZICAI005164Non-Human Primate Core for COVID Effort72025
P30CA008748Cancer Center Support Grant62025

1 to 10 of 917Source NIH's project files

See all 917 nih grants

Papers1,302

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Diverging pathomechanisms underlying collagen I-related and MBTPS2-related osteogenesis imperfecta: insights from patient-derived fibroblasts and iPSC-based modelling of bone.Front Endocrinol (Lausanne)202642601949PubTator, text miningPubMed
A Versatile Multiplexed Immunofluorescence Strategy for Efficient, Host-Independent, and Scalable Spatial Protein Profiling.Small Methods202642305051PubTator, text miningPubMed
Lipid metabolism-related gene expression predicts prognostic outcomes in lung adenocarcinoma.Transl Cancer Res202642180928PubTator, text miningPubMed
Double proline- substituted porcine epidemic diarrhea virus full-length spike mRNA vaccine confers enhanced immunogenicity and protective efficacy compared to conventional inactivated vaccine.Vaccine202642142524PubTator, text miningPubMed
Long-read RNA sequencing reveals extensive transcript isoform changes in a patient with IFAP syndrome with a recurrent intronic MBTPS2 variant.Hum Genome Var202641980932PubTator, text miningPubMed
Recurrent MBTPS2 variant c.970+5G>A in IFAP syndrome: a mutational hotspot.Hum Genome Var202641974659PubTator, text miningPubMed
Impaired bone matrix turnover with selective small bone fragility in a child with TENT5A-associated osteogenesis imperfecta.JBMR Plus202641908159PubTator, text miningPubMed
Defining Histological Patterns in Inherited Ichthyoses: Toward a Diagnostic Algorithm Based on 66 Confirmed Cases.Dermatopathology (Basel)202641892076PubTator, text miningPubMed
Conformational dynamics of SARS-CoV-2 spike on a membrane reveals the allosteric effects of furin cleavage and the D614G mutation.Sci Adv202641861002PubTator, text miningPubMed
Functional interrogation of candidate cis-regulatory elements at the LDLR locus.PLoS Genet202641843552PubTator, text miningPubMed

1 to 10 of 1,302

See all 1,302 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/51360

GET https://conductscience.org/api/genes/v1/51360/patents?page=2