Gene · 51360
MBTPS2: membrane bound transcription factor peptidase, site 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MBTPS2: membrane bound transcription factor peptidase, site 2. Genes, record 51360. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51360
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43462 | Membrane-bound transcription factor site-2 protease | 519 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents36
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026082974 A | 2026-05-19 | 133 | O43462 | Espacenet |
| EP 4705273 A2 | 2026-03-11 | 577 | O43462 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 53217 | O43462 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 10170 | O43462 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2567 | O43462 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2567 | O43462 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 10170 | O43462 | Espacenet |
| JP 2025013347 A | 2025-01-24 | 577 | O43462 | Espacenet |
| EP 4406585 A2 | 2024-07-31 | 577 | O43462 | Espacenet |
| JP 2023011696 A | 2023-01-24 | 577 | O43462 | Espacenet |
1 to 10 of 36
See all 36 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants917
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MBTPS2 papers | Newest fiscal year |
|---|---|---|---|
| ZIAAI005149 | Immunogen Design for SARS-CoV-2 | 12 | 2025 |
| P51OD011132 | Emory National Primate Research Center | 11 | 2025 |
| UM1AI148373 | Kaiser Washington Vaccine and Treatment Evaluation Unit | 9 | 2025 |
| UM1AI148576 | Vaccine and Treatment Evaluation Units | 9 | 2025 |
| UM1AI148684 | Leadership Group for the Infectious Diseases Clinical Research Consortium (IDCRCLG) | 9 | 2025 |
| ZIAAI005151 | Innate and Adaptive Immune Responses in SARS-CoV-2 infection (COVID-19) | 9 | 2025 |
| ZIAAI005022 | Antibody Neutralization Mechanisms | 8 | 2025 |
| ZIAAI005033 | Immune Responses To Human Pathogens | 7 | 2025 |
| ZICAI005164 | Non-Human Primate Core for COVID Effort | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
1 to 10 of 917Source NIH's project files
See all 917 nih grantsPapers1,302
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Diverging pathomechanisms underlying collagen I-related and MBTPS2-related osteogenesis imperfecta: insights from patient-derived fibroblasts and iPSC-based modelling of bone. | Front Endocrinol (Lausanne) | 2026 | 42601949 | PubTator, text mining | PubMed |
| A Versatile Multiplexed Immunofluorescence Strategy for Efficient, Host-Independent, and Scalable Spatial Protein Profiling. | Small Methods | 2026 | 42305051 | PubTator, text mining | PubMed |
| Lipid metabolism-related gene expression predicts prognostic outcomes in lung adenocarcinoma. | Transl Cancer Res | 2026 | 42180928 | PubTator, text mining | PubMed |
| Double proline- substituted porcine epidemic diarrhea virus full-length spike mRNA vaccine confers enhanced immunogenicity and protective efficacy compared to conventional inactivated vaccine. | Vaccine | 2026 | 42142524 | PubTator, text mining | PubMed |
| Long-read RNA sequencing reveals extensive transcript isoform changes in a patient with IFAP syndrome with a recurrent intronic MBTPS2 variant. | Hum Genome Var | 2026 | 41980932 | PubTator, text mining | PubMed |
| Recurrent MBTPS2 variant c.970+5G>A in IFAP syndrome: a mutational hotspot. | Hum Genome Var | 2026 | 41974659 | PubTator, text mining | PubMed |
| Impaired bone matrix turnover with selective small bone fragility in a child with TENT5A-associated osteogenesis imperfecta. | JBMR Plus | 2026 | 41908159 | PubTator, text mining | PubMed |
| Defining Histological Patterns in Inherited Ichthyoses: Toward a Diagnostic Algorithm Based on 66 Confirmed Cases. | Dermatopathology (Basel) | 2026 | 41892076 | PubTator, text mining | PubMed |
| Conformational dynamics of SARS-CoV-2 spike on a membrane reveals the allosteric effects of furin cleavage and the D614G mutation. | Sci Adv | 2026 | 41861002 | PubTator, text mining | PubMed |
| Functional interrogation of candidate cis-regulatory elements at the LDLR locus. | PLoS Genet | 2026 | 41843552 | PubTator, text mining | PubMed |
1 to 10 of 1,302
See all 1,302 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/51360
GET https://conductscience.org/api/genes/v1/51360/patents?page=2