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Gene · 5139

PDE3A: phosphodiesterase 3A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PDE3A: phosphodiesterase 3A. Genes, record 5139. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5139

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Gene

Symbol
PDE3A
HGNC
Name
phosphodiesterase 3A
HGNC
NCBI Gene ID
5139
NCBI Gene
HGNC ID
HGNC:8778
HGNC
Ensembl
ENSG00000172572
NCBI Gene
Aliases
CGI-PDE, CGI-PDE A, CGI-PDE-A, HTNB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14432cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A1,1419Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4640849 A22025-10-291140Q14432Espacenet
EP 4641201 A22025-10-297652Q14432Espacenet
JP 2025529142 A2025-09-043427Q14432Espacenet
US 12371689 B22025-07-293427Q14432Espacenet
JP 2025519096 A2025-06-241140Q14432Espacenet
JP 2025517969 A2025-06-127652Q14432Espacenet
JP 2025032204 A2025-03-1133153Q14432Espacenet
JP 2025004127 A2025-01-147Q14432Espacenet
EP 4463571 A12024-11-20237Q14432Espacenet
EP 4461818 A22024-11-1333153Q14432Espacenet

1 to 10 of 43

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Drugs21

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMINOPHYLLINECHEMBL1370561Phosphodiesterase 3 inhibitorINHIBITORChEMBL
ANAGRELIDECHEMBL760Phosphodiesterase 3 inhibitorINHIBITORChEMBL
ANAGRELIDE HYDROCHLORIDECHEMBL1200759Phosphodiesterase 3 inhibitorINHIBITORChEMBL
CILOSTAZOLCHEMBL799Phosphodiesterase 3A inhibitorINHIBITORChEMBL
DIPYRIDAMOLECHEMBL9323',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL
DYPHYLLINECHEMBL1752Phosphodiesterase 3A inhibitorINHIBITORChEMBL
ENOXIMONECHEMBL249856Phosphodiesterase 3 inhibitorINHIBITORChEMBL
ENSIFENTRINECHEMBL4594287Phosphodiesterase 3 inhibitorINHIBITORChEMBL
IBUDILASTCHEMBL19449Phosphodiesterase 3A inhibitorINHIBITORChEMBL
INAMRINONECHEMBL12856Phosphodiesterase 3A inhibitorINHIBITORChEMBL

1 to 10 of 21

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Trials338

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07600385CILOSTAZOLPHASE3ClinicalTrials.gov
NCT07588932CILOSTAZOLEARLY_PHASE1ClinicalTrials.gov
NCT07436689LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT07349472PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT07348510AMINOPHYLLINEClinicalTrials.gov
NCT07315139PENTOXIFYLLINEClinicalTrials.gov
NCT07288398LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT07252518PENTOXIFYLLINEClinicalTrials.gov
NCT07238985CILOSTAZOLPHASE1/PHASE2ClinicalTrials.gov
NCT07199504DIPYRIDAMOLEPHASE2/PHASE3ClinicalTrials.gov

1 to 10 of 338

See all 338 trials

NIH grants965

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDE3A papersNewest fiscal year
T32HL007227Pathophysiology of Myocardial Disease62025
P30DK063491Diabetes Research Center (DRC)52025
R01HD072929Optimal Oxygenation in Neonatal Lung Injury52025
R35CA197568Lung Adenocarcinoma: From Genome Alterations to Therapeutic Discovery42025
ZICHL006019Light Microscopy Core42025
I01BX003362Genetics of Cardiometabolic Diseases in the VA Population32025
P30CA068485Cancer Center Support Grant32025
P30DK020572Michigan Diabetes Research Center (MDRC)32025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION32025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal32025

1 to 10 of 965Source NIH's project files

See all 965 nih grants

Papers1,182

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of transcriptomic signatures associated with an ac4C related gene set and candidate expression based clusters in osteoarthritis through integrative bioinformatics.PLoS One202642784567PubTator, text miningPubMed
Anagrelide Remodels the PDE3A-SLFN12 Interactome to Associate with Translation Initiation Machinery in Cancer Cell Lines.Mol Cell Proteomics202642759699PubTator, text miningPubMed
The PDE3-specific inhibitor milrinone improves asthenozoospermic sperm function by regulating cAMP-PKA signaling pathway and energy metabolism.Reprod Fertil Dev202642692814PubTator, text miningPubMed
A framework to map cAMP signalling nanodomains: phosphodiesterase-centred phosphoproteome-interactome networks (pPINs) in cardiac myocytes.J Mol Endocrinol202642690226PubTator, text miningPubMed
Driver vs. passenger: Primary resistance to larotrectinib in synovial sarcoma harboring concurrent SS18 rearrangement and PDE3A-NTRK2 fusion.Tumori202642376758PubTator, text miningPubMed
Preclinical response of uveal melanomas to the velcrin compound, BAY 2666605.Mol Cancer Ther202642227579PubTator, text miningPubMed
Pan-cancer ex vivo target evaluation of phosphodiesterase 3 A (PDE3A).J Mol Med (Berl)202642047795PubTator, text miningPubMed
The Role of A-Kinase Anchoring Proteins for Inhibitory cAMP Signalling in Platelets.Cells202641892342PubTator, text miningPubMed
cAMP/PKA signaling in endocrine hypertension: genetic mechanisms and pathophysiological insights.Front Endocrinol (Lausanne)202641816209PubTator, text miningPubMed
Biological implications and therapeutic potential of phosphodiesterase inhibitors: A review.Medicine (Baltimore)202641790675PubTator, text miningPubMed

1 to 10 of 1,182

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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