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Gene · 51393

TRPV2: transient receptor potential cation channel subfamily V member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TRPV2: transient receptor potential cation channel subfamily V member 2. Genes, record 51393. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51393

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Gene

Symbol
TRPV2
HGNC
Name
transient receptor potential cation channel subfamily V member 2
HGNC
NCBI Gene ID
51393
NCBI Gene
HGNC ID
HGNC:18082
HGNC
Ensembl
ENSG00000187688
NCBI Gene
Aliases
VRL, VRL-1, VRL1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y5S1Transient receptor potential cation channel subfamily V member 27641Ensembl, GeneID, HGNC

Source UniProt

Patents57

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467658Q9Y5S1Espacenet
EP 4650780 A22025-11-196724Q9Y5S1Espacenet
EP 4641201 A22025-10-296490Q9Y5S1Espacenet
JP 2025529142 A2025-09-045077Q9Y5S1Espacenet
US 12371689 B22025-07-295077Q9Y5S1Espacenet
JP 2025517969 A2025-06-126490Q9Y5S1Espacenet
JP 2025517970 A2025-06-126724Q9Y5S1Espacenet
JP 2023169439 A2023-11-301Q9Y5S1Espacenet
US 11446398 B22022-09-2090378Q9Y5S1Espacenet
US 11400116 B22022-08-024172Q9Y5S1Espacenet

1 to 10 of 57

See all 57 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants777

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRPV2 papersNewest fiscal year
R01CA206573Structure and function of Transient Receptor Potential Channels122025
R01NS107253Single-Particle Cryo-EM Characterization of AMPA Receptor Functional States102025
R01AR078814Structural and functional principles of activation and regulation of the transient receptor potential channel TRPV3.52025
R01GM093290Regulation of the epithelial Ca2+ channels TRPV6 and TRPV552025
P30CA008748Cancer Center Support Grant42025
ZIANS002945Gating mechanisms and pharmacology of voltage-activated ion channels42025
P30EY014800University of Utah Core Vision Research Grant32025
R01EY027920Molecular mechanisms of mechanotransduction in the aqueous outflow pathway32025
R35GM144120Structure and Function of TRPV channels32025
T32EY024234Vision Research Training Grant at the University of Utah32025

1 to 10 of 777Source NIH's project files

See all 777 nih grants

Papers1,706

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Correction to "Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression".ACS Cent Sci202642799159PubTator, text miningPubMed
Characterization of TRPV2-associated pathology in Parkinson's disease and therapeutic modulation using Tranilast.Front Cell Neurosci202642625634PubTator, text miningPubMed
Structural origins of species-specific differences in TRPV2 activation.Nat Commun202642624855PubTator, text miningPubMed
Inactivation Switch for Run-up in TRPV2.Res Sq202642620408PubTator, text miningPubMed
Correction: Novel recombinant protein PK5-Gal-3C enhances the anti-tumor activity of T cells via binding with TRPV2.Cancer Immunol Immunother202642616099PubTator, text miningPubMed
Transient receptor potential vanilloid 2 functions as a directional driver for hepoxilin A3-mediated neutrophil migration.Sci Adv202642536751PubTator, text miningPubMed
Transient receptor potential vanilloid channels in inflammatory bowel diseases: linking inflammation, angiogenesis, and oxidative stress.Inflammopharmacology202642507268PubTator, text miningPubMed
Structural insights and regulatory mechanisms of endogenous modulation of TRPV2 as a potential drug target.Biochem Pharmacol202642498156PubTator, text miningPubMed
Structure-based virtual screening for selective connexin hemichannel blockers: a historical perspective on the discovery of a small organic inhibitor.Front Pharmacol202642428492PubTator, text miningPubMed
Pharmacological modulation of TRPV2 enhances migration and induces Immunoglobulin E (IgE)-independent degranulation of mast cells.Cell Calcium202642424794PubTator, text miningPubMed

1 to 10 of 1,706

See all 1,706 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/51393

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