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PDE4A: phosphodiesterase 4A

1 protein, 30 patents, 31 drugs, 534 trials, 1,907 NIH grants and 4,647 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPDE4AHGNC
Namephosphodiesterase 4AHGNC
NCBI Gene ID5141NCBI Gene
HGNC IDHGNC:8780HGNC
EnsemblENSG00000065989NCBI Gene
AliasesDPDE2, PDE4, PDE46NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P278153',5'-cyclic-AMP phosphodiesterase 4A8863Ensembl, GeneID, HGNCUniProt

Patents 30

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457709P27815Espacenet
EP 4640849 A22025-10-291571P27815Espacenet
EP 4641201 A22025-10-2910679P27815Espacenet
JP 2025519096 A2025-06-241571P27815Espacenet
JP 2025517969 A2025-06-1210679P27815Espacenet
JP 2025081323 A2025-05-271P27815Espacenet
JP 2025004127 A2025-01-149P27815Espacenet
EP 4374872 A12024-05-2920P27815Espacenet
JP 2023144094 A2023-10-06119P27815Espacenet
US 11666642 B22023-06-06119P27815Espacenet

Drugs 31

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMINOPHYLLINECHEMBL1370561Phosphodiesterase 4 inhibitorINHIBITORChEMBL
AMLEXANOXCHEMBL1096Phosphodiesterase 4 inhibitorINHIBITORChEMBL
APREMILASTCHEMBL514800Phosphodiesterase 4 inhibitorINHIBITORChEMBL
CILOMILASTCHEMBL511115Phosphodiesterase 4 inhibitorINHIBITORChEMBL
CRISABOROLECHEMBL484785Phosphodiesterase 4 inhibitorINHIBITORChEMBL
DIFAMILASTCHEMBL3989968Phosphodiesterase 4 inhibitorINHIBITORChEMBL
DIPYRIDAMOLECHEMBL9323',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL
DOVRAMILASTCHEMBL4297460Phosphodiesterase 4 inhibitorINHIBITORChEMBL
DROTAVERINECHEMBL551978Phosphodiesterase 4 inhibitorINHIBITORChEMBL
DYPHYLLINECHEMBL1752Phosphodiesterase 4 inhibitorINHIBITORChEMBL

Trials 534

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07566351ROFLUMILASTPHASE2ClinicalTrials.gov
NCT07543640ROFLUMILASTPHASE2ClinicalTrials.gov
NCT07537751CRISABOROLEClinicalTrials.gov
NCT07519174CRISABOROLEClinicalTrials.gov
NCT07438509CRISABOROLEPHASE4ClinicalTrials.gov
NCT07437534CRISABOROLEPHASE4ClinicalTrials.gov
NCT07398651APREMILASTClinicalTrials.gov
NCT07367932CRISABOROLEPHASE4ClinicalTrials.gov
NCT07366268APREMILASTClinicalTrials.gov
NCT07349472PENTOXIFYLLINEPHASE2ClinicalTrials.gov

NIH grants 1907

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIAMH002793PET Radiopharmaceutical Sciences132,025NIH's project files
R01DK073368Mechanisms of Compartmentalized cAMP Signaling112,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award92,025NIH's project files
ZIAMH002852Clinical Evaluation of PET Radiotracers92,025NIH's project files
P30CA013148Comprehensive Cancer Center Support Grant82,025NIH's project files
P20GM113226Hepatobiology and Toxicology COBRE72,025NIH's project files
P50AA024337The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ Injury72,025NIH's project files
U01AA0135207/11 Biochemical and Genetic Determinants of Alcohol Consumption62,025NIH's project files
K24AA025704Clinical Neuroscience of Alcoholism: Integrating Neuroscience and Clinical Trials52,025NIH's project files
P30CA054174Mays Cancer Center at UT Health SA52,025NIH's project files

Papers 4647

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822276PubTator, text miningPubMed
42791651PubTator, text miningPubMed
42768757PubTator, text miningPubMed
42743079PubTator, text miningPubMed
42719222PubTator, text miningPubMed
42697380PubTator, text miningPubMed
42679515PubTator, text miningPubMed
42667317PubTator, text miningPubMed
42653130PubTator, text miningPubMed
42648557PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license