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Gene · 5142

PDE4B: phosphodiesterase 4B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PDE4B: phosphodiesterase 4B. Genes, record 5142. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5142

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Gene

Symbol
PDE4B
HGNC
Name
phosphodiesterase 4B
HGNC
NCBI Gene ID
5142
NCBI Gene
HGNC ID
HGNC:8781
HGNC
Ensembl
ENSG00000184588
NCBI Gene
Aliases
DPDE4, PDEIVB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q073433',5'-cyclic-AMP phosphodiesterase 4B73643Ensembl, GeneID, HGNC

Source UniProt

Patents60

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457714Q07343Espacenet
JP 2026004568 A2026-01-1457715Q07343Espacenet
JP 2026004568 A2026-01-1457717Q07343Espacenet
EP 4650780 A22025-11-195945Q07343Espacenet
EP 4641201 A22025-10-295680Q07343Espacenet
EP 4641202 A22025-10-295038Q07343Espacenet
JP 2025517969 A2025-06-125680Q07343Espacenet
JP 2025517970 A2025-06-125945Q07343Espacenet
JP 2025081323 A2025-05-278Q07343Espacenet
KR 1020250017231 A2025-02-045038Q07343Espacenet

1 to 10 of 60

See all 60 patents

Drugs31

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMINOPHYLLINECHEMBL1370561Phosphodiesterase 4 inhibitorINHIBITORChEMBL
AMLEXANOXCHEMBL1096Phosphodiesterase 4 inhibitorINHIBITORChEMBL
APREMILASTCHEMBL514800Phosphodiesterase 4 inhibitorINHIBITORChEMBL
CILOMILASTCHEMBL511115Phosphodiesterase 4 inhibitorINHIBITORChEMBL
CRISABOROLECHEMBL484785Phosphodiesterase 4 inhibitorINHIBITORChEMBL
DIFAMILASTCHEMBL3989968Phosphodiesterase 4 inhibitorINHIBITORChEMBL
DIPYRIDAMOLECHEMBL9323',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL
DOVRAMILASTCHEMBL4297460Phosphodiesterase 4 inhibitorINHIBITORChEMBL
DROTAVERINECHEMBL551978Phosphodiesterase 4 inhibitorINHIBITORChEMBL
DYPHYLLINECHEMBL1752Phosphodiesterase 4 inhibitorINHIBITORChEMBL

1 to 10 of 31

See all 31 drugs

Trials534

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,398

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDE4B papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).92025
R01DA0548697/7 Psychiatric Genomics Consortium: Advancing Discovery and Impact62025
DP1DA054394Building Bridges to Allow Cross-species Translational genetics for the Study of Addiction52025
I01BX004820Genetic Vulnerability for Sustained Multi-Substance Use in MVP52025
K01AA030083Mass Multivariate Derivation and Validation of AUD Biotypes using Developmental Imaging and Genomic Approaches52025
K01DA051759Identifying genetic sources of comorbidity between cannabis and schizophrenia using genome-wide and integrative omics data52025
P30CA054174Mays Cancer Center at UT Health SA52025
P50AA012870Center for the Translational Neuroscience of Alcoholism52025
ZIAMH002793PET Radiopharmaceutical Sciences52025
P30CA021765Cancer Center Support Grant (CCSG)42025

1 to 10 of 1,398Source NIH's project files

See all 1,398 nih grants

Papers1,785

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Nerandomilast is Associated With Altered Alveolar Epithelial Cell State Dynamics While Attenuating Fibrotic Remodeling in Pulmonary Fibrosis.Genes Cells202642827411PubTator, text miningPubMed
Endoplasmic reticulum stress and maladaptive repair in fibrotic interstitial lung diseases: A human-evidence-based narrative review.Ther Adv Respir Dis202642813994PubTator, text miningPubMed
The emerging role of PDE4 inhibitors for the treatment of pulmonary fibrosis.Expert Rev Clin Pharmacol202642768757PubTator, text miningPubMed
MiR-23b-3p exerts a protective effect in hypertensive nephropathy by inhibiting fibrosis and inflammation.Am J Hypertens202642726087PubTator, text miningPubMed
Reconfiguring the macrophage-centric intercellular network in pulmonary fibrosis: Emerging perspectives and therapeutic opportunities.Pharmacol Res202642705427PubTator, text miningPubMed
ALDH2 regulates oxaliplatin sensitivity via PDE4B in p53-mutant colorectal cancer.Int J Med Sci202642694559PubTator, text miningPubMed
Pharmacokinetics and Safety of Nerandomilast in Healthy Volunteers.Eur J Drug Metab Pharmacokinet202642563128PubTator, text miningPubMed
Elucidating the molecular mechanisms of paeoniflorin intervention in oral lichen planus: a computational biology and bioinformatics-based research strategy.Front Bioinform202642539528PubTator, text miningPubMed
Precision Modulation of the PDE4 Pathway: The Emerging Role of Nerandomilast in Pulmonary Fibrosis.J Pharm Technol202642490950PubTator, text miningPubMed
Selective phosphodiesterase 4B inhibition in fibrotic lung disease: a scoping review of vascular-immune mechanisms and extrapulmonary implications.Eur Respir Rev202642486502PubTator, text miningPubMed

1 to 10 of 1,785

See all 1,785 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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