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Gene · 51422

PRKAG2: protein kinase AMP-activated non-catalytic subunit gamma 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PRKAG2: protein kinase AMP-activated non-catalytic subunit gamma 2. Genes, record 51422. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51422

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Gene

Symbol
PRKAG2
HGNC
Name
protein kinase AMP-activated non-catalytic subunit gamma 2
HGNC
NCBI Gene ID
51422
NCBI Gene
HGNC ID
HGNC:9386
HGNC
Ensembl
ENSG00000106617
NCBI Gene
Aliases
AAKG, AAKG2, CMH6, GSDH, H91620p, WPWS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UGJ05'-AMP-activated protein kinase subunit gamma-25690Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459758Q9UGJ0Espacenet
EP 4641201 A22025-10-292913Q9UGJ0Espacenet
JP 2025517969 A2025-06-122913Q9UGJ0Espacenet
JP 2025032204 A2025-03-1134037Q9UGJ0Espacenet
EP 4461818 A22024-11-1334037Q9UGJ0Espacenet
US 11884978 B22024-01-30680Q9UGJ0Espacenet
JP 2023058610 A2023-04-2534037Q9UGJ0Espacenet
US 11446398 B22022-09-2068313Q9UGJ0Espacenet
JP 2022524081 A2022-04-27171284Q9UGJ0Espacenet
KR 1020210090147 A2021-07-1920Q9UGJ0Espacenet

1 to 10 of 27

See all 27 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
ACADESINECHEMBL1551724AMP-activated protein kinase, AMPK activatorACTIVATOR

Source ChEMBL

Trials2

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01813838ACADESINEPHASE1/PHASE2ClinicalTrials.gov
NCT00559624ACADESINEPHASE1/PHASE2ClinicalTrials.gov

NIH grants1,509

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePRKAG2 papersNewest fiscal year
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal122025
P30DK063491Diabetes Research Center (DRC)102025
P30CA016672Cancer Center Support Grant82025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION42025
R01DK093757Genetic epidemiology of rare and regulatory variants for metabolic traits42025
R01HL132401Mechanisms and Therapeutic Targeting of DNA Damage in Dilated Cardiomyopathy Caused by LMNA Mutations42025
R01NS017950Precursors of Stroke Incidence and Prognosis42025
P30AG062677Mayo Alzheimer's Disease Research Center32025
P30CA068485Cancer Center Support Grant32025
P30CA071789University of Hawaii Cancer Center CCSG32025

1 to 10 of 1,509Source NIH's project files

See all 1,509 nih grants

Papers1,302

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetic loci responsible for atrioventricular block in children.Front Cell Dev Biol202642798645PubTator, text miningPubMed
Hypertrophic Phenotype in an Adolescent from the Amazon Region Associated with Combined Variants in the GLA, TTR, and PRKAG2 genes.Arq Bras Cardiol202642788550PubTator, text miningPubMed
AMPKγ2-Myosin Interaction: A Glycogen-Independent Trigger for PRKAG2 Cardiomyopathy.J Cardiovasc Transl Res202642663759PubTator, text miningPubMed
Genetic overlap between estimated glomerular filtration rate and cardiovascular disease identifies potential targets for cardiorenal syndrome.Ren Fail202642661344PubTator, text miningPubMed
[Ventricular hypertrophy and pre-excitation: a diagnostic clue to PRKAG2-related cardiomyopathy].G Ital Cardiol (Rome)202642643146PubTator, text miningPubMed
Ambient PM2.5 exposure and sleep quality: Evidence from circadian DNA methylation signatures in a population-based study.J Hazard Mater202642537304PubTator, text miningPubMed
Left Ventricular Hypertrophy With Pre-Excitation: Thinking Beyond the Usual Hypertrophic Cardiomyopathy Diagnosis.JACC Case Rep202642530173PubTator, text miningPubMed
The Innocent Delta Wave in Progressive Cardiomyopathy - Culprit vs Bystander.Am J Cardiol202642476209PubTator, text miningPubMed
Cardioneural and accessory atrioventricular pathway ablation for vagally mediated atrial fibrillation in PRKAG2 syndrome.Heart Lung202642463397PubTator, text miningPubMed
Cardiomyopathy in glycogen storage diseases: diagnosis, prognosis, and advanced management.Heart Fail Rev202642430006PubTator, text miningPubMed

1 to 10 of 1,302

See all 1,302 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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