Gene · 51422
PRKAG2: protein kinase AMP-activated non-catalytic subunit gamma 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PRKAG2: protein kinase AMP-activated non-catalytic subunit gamma 2. Genes, record 51422. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51422
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UGJ0 | 5'-AMP-activated protein kinase subunit gamma-2 | 569 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents27
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 59758 | Q9UGJ0 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2913 | Q9UGJ0 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2913 | Q9UGJ0 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 34037 | Q9UGJ0 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 34037 | Q9UGJ0 | Espacenet |
| US 11884978 B2 | 2024-01-30 | 680 | Q9UGJ0 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 34037 | Q9UGJ0 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 68313 | Q9UGJ0 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 171284 | Q9UGJ0 | Espacenet |
| KR 1020210090147 A | 2021-07-19 | 20 | Q9UGJ0 | Espacenet |
1 to 10 of 27
See all 27 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| ACADESINE | CHEMBL1551724 | AMP-activated protein kinase, AMPK activator | ACTIVATOR |
Source ChEMBL
Trials2
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT01813838 | ACADESINE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT00559624 | ACADESINE | PHASE1/PHASE2 | ClinicalTrials.gov |
NIH grants1,509
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PRKAG2 papers | Newest fiscal year |
|---|---|---|---|
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 12 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| R01DK062370 | Identifying Genes for Type 2 Diabetes: FUSION | 4 | 2025 |
| R01DK093757 | Genetic epidemiology of rare and regulatory variants for metabolic traits | 4 | 2025 |
| R01HL132401 | Mechanisms and Therapeutic Targeting of DNA Damage in Dilated Cardiomyopathy Caused by LMNA Mutations | 4 | 2025 |
| R01NS017950 | Precursors of Stroke Incidence and Prognosis | 4 | 2025 |
| P30AG062677 | Mayo Alzheimer's Disease Research Center | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| P30CA071789 | University of Hawaii Cancer Center CCSG | 3 | 2025 |
1 to 10 of 1,509Source NIH's project files
See all 1,509 nih grantsPapers1,302
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Genetic loci responsible for atrioventricular block in children. | Front Cell Dev Biol | 2026 | 42798645 | PubTator, text mining | PubMed |
| Hypertrophic Phenotype in an Adolescent from the Amazon Region Associated with Combined Variants in the GLA, TTR, and PRKAG2 genes. | Arq Bras Cardiol | 2026 | 42788550 | PubTator, text mining | PubMed |
| AMPKγ2-Myosin Interaction: A Glycogen-Independent Trigger for PRKAG2 Cardiomyopathy. | J Cardiovasc Transl Res | 2026 | 42663759 | PubTator, text mining | PubMed |
| Genetic overlap between estimated glomerular filtration rate and cardiovascular disease identifies potential targets for cardiorenal syndrome. | Ren Fail | 2026 | 42661344 | PubTator, text mining | PubMed |
| [Ventricular hypertrophy and pre-excitation: a diagnostic clue to PRKAG2-related cardiomyopathy]. | G Ital Cardiol (Rome) | 2026 | 42643146 | PubTator, text mining | PubMed |
| Ambient PM2.5 exposure and sleep quality: Evidence from circadian DNA methylation signatures in a population-based study. | J Hazard Mater | 2026 | 42537304 | PubTator, text mining | PubMed |
| Left Ventricular Hypertrophy With Pre-Excitation: Thinking Beyond the Usual Hypertrophic Cardiomyopathy Diagnosis. | JACC Case Rep | 2026 | 42530173 | PubTator, text mining | PubMed |
| The Innocent Delta Wave in Progressive Cardiomyopathy - Culprit vs Bystander. | Am J Cardiol | 2026 | 42476209 | PubTator, text mining | PubMed |
| Cardioneural and accessory atrioventricular pathway ablation for vagally mediated atrial fibrillation in PRKAG2 syndrome. | Heart Lung | 2026 | 42463397 | PubTator, text mining | PubMed |
| Cardiomyopathy in glycogen storage diseases: diagnosis, prognosis, and advanced management. | Heart Fail Rev | 2026 | 42430006 | PubTator, text mining | PubMed |
1 to 10 of 1,302
See all 1,302 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/51422
GET https://conductscience.org/api/genes/v1/51422/patents?page=2