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Gene · 5143

PDE4C: phosphodiesterase 4C

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PDE4C: phosphodiesterase 4C. Genes, record 5143. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5143

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Gene

Symbol
PDE4C
HGNC
Name
phosphodiesterase 4C
HGNC
NCBI Gene ID
5143
NCBI Gene
HGNC ID
HGNC:8782
HGNC
Ensembl
ENSG00000105650
NCBI Gene
Aliases
DPDE1, PDE21
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q084933',5'-cyclic-AMP phosphodiesterase 4C7121Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457721Q08493Espacenet
EP 4641201 A22025-10-297093Q08493Espacenet
JP 2025517969 A2025-06-127093Q08493Espacenet
JP 2025081323 A2025-05-2712Q08493Espacenet
US 12264368 B22025-04-01440Q08493Espacenet
US 12264368 B22025-04-01441Q08493Espacenet
JP 2025004127 A2025-01-1411Q08493Espacenet
KR 1020240173306 A2024-12-119Q08493Espacenet
EP 4374872 A12024-05-2944Q08493Espacenet
EP 4374872 A12024-05-2952Q08493Espacenet

1 to 10 of 38

See all 38 patents

Drugs31

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMINOPHYLLINECHEMBL1370561Phosphodiesterase 4 inhibitorINHIBITORChEMBL
AMLEXANOXCHEMBL1096Phosphodiesterase 4 inhibitorINHIBITORChEMBL
APREMILASTCHEMBL514800Phosphodiesterase 4 inhibitorINHIBITORChEMBL
CILOMILASTCHEMBL511115Phosphodiesterase 4 inhibitorINHIBITORChEMBL
CRISABOROLECHEMBL484785Phosphodiesterase 4 inhibitorINHIBITORChEMBL
DIFAMILASTCHEMBL3989968Phosphodiesterase 4 inhibitorINHIBITORChEMBL
DIPYRIDAMOLECHEMBL9323',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL
DOVRAMILASTCHEMBL4297460Phosphodiesterase 4 inhibitorINHIBITORChEMBL
DROTAVERINECHEMBL551978Phosphodiesterase 4 inhibitorINHIBITORChEMBL
DYPHYLLINECHEMBL1752Phosphodiesterase 4 inhibitorINHIBITORChEMBL

1 to 10 of 31

See all 31 drugs

Trials534

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants306

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDE4C papersNewest fiscal year
ZIAMH002852Clinical Evaluation of PET Radiotracers32025
P30CA013148Comprehensive Cancer Center Support Grant22025
P30CA042014Cancer Center Support Grant22025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology22025
ZIAMH002793PET Radiopharmaceutical Sciences22025
P01CA108671Myeloproliferative Neoplasms-Research Consortium12025
P20GM113226Hepatobiology and Toxicology COBRE12025
P30AG050911Oklahoma Nathan Shock Center of Excellence in Basic Biology of Aging12025
P30CA006927Comprehensive Cancer Center Program at Fox Chase12025
P30CA015704Cancer Center Support Grant12025

1 to 10 of 306Source NIH's project files

See all 306 nih grants

Papers451

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Development of a Model for Predicting Chronological Age Based on DNA Methylation Data from Buccal Swabs Using Ion Torrent S5 Technology.Int J Mol Sci202642589712PubTator, text miningPubMed
DNA Methylation at Core N-Methyl-D-Aspartate (NMDA) Receptor Genes Reveals a Glutamatergic Signature of Aging in Post-COVID Whole Blood With Implications for Long-COVID Neuropsychiatric Sequelae.Cureus202642471918PubTator, text miningPubMed
Early blood DNA methylation patterns associated with glycemic progression in a prospective Indian cohort.Clin Epigenetics202641992370PubTator, text miningPubMed
A targeted epigenetic clock for simultaneous assessment of biological aging and cancer-associated methylation drift.Clin Epigenetics202641963974PubTator, text miningPubMed
Cell-Cell Interactome-Based Pathogenesis and Therapies for Osteosarcoma.Cells202641892359PubTator, text miningPubMed
Examining Epigenetic Age in Women with Different Obesity Conditions Using DNA Methylation at the FHL2 Gene.Methods Protoc202641874164PubTator, text miningPubMed
PDE4C stabilized by ELAVL1 promotes lymph node metastasis in papillary thyroid cancer.Am J Cancer Res202641868681PubTator, text miningPubMed
Biological implications and therapeutic potential of phosphodiesterase inhibitors: A review.Medicine (Baltimore)202641790675PubTator, text miningPubMed
Lifespan-Extending Endogenous Metabolites.Aging Cell202641527327PubTator, text miningPubMed
Biopsy and Blood Gene Expression Distinguish Injury, Subclinical and Clinical Rejection in Kidney Transplant Recipients.Transplant Direct202641404547PubTator, text miningPubMed

1 to 10 of 451

See all 451 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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