Gene · 5143
PDE4C: phosphodiesterase 4C
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PDE4C: phosphodiesterase 4C. Genes, record 5143. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5143
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q08493 | 3',5'-cyclic-AMP phosphodiesterase 4C | 712 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents38
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 57721 | Q08493 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7093 | Q08493 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 7093 | Q08493 | Espacenet |
| JP 2025081323 A | 2025-05-27 | 12 | Q08493 | Espacenet |
| US 12264368 B2 | 2025-04-01 | 440 | Q08493 | Espacenet |
| US 12264368 B2 | 2025-04-01 | 441 | Q08493 | Espacenet |
| JP 2025004127 A | 2025-01-14 | 11 | Q08493 | Espacenet |
| KR 1020240173306 A | 2024-12-11 | 9 | Q08493 | Espacenet |
| EP 4374872 A1 | 2024-05-29 | 44 | Q08493 | Espacenet |
| EP 4374872 A1 | 2024-05-29 | 52 | Q08493 | Espacenet |
1 to 10 of 38
See all 38 patentsDrugs31
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AMINOPHYLLINE | CHEMBL1370561 | Phosphodiesterase 4 inhibitor | INHIBITOR | ChEMBL |
| AMLEXANOX | CHEMBL1096 | Phosphodiesterase 4 inhibitor | INHIBITOR | ChEMBL |
| APREMILAST | CHEMBL514800 | Phosphodiesterase 4 inhibitor | INHIBITOR | ChEMBL |
| CILOMILAST | CHEMBL511115 | Phosphodiesterase 4 inhibitor | INHIBITOR | ChEMBL |
| CRISABOROLE | CHEMBL484785 | Phosphodiesterase 4 inhibitor | INHIBITOR | ChEMBL |
| DIFAMILAST | CHEMBL3989968 | Phosphodiesterase 4 inhibitor | INHIBITOR | ChEMBL |
| DIPYRIDAMOLE | CHEMBL932 | 3',5'-cyclic phosphodiesterase inhibitor | INHIBITOR | ChEMBL |
| DOVRAMILAST | CHEMBL4297460 | Phosphodiesterase 4 inhibitor | INHIBITOR | ChEMBL |
| DROTAVERINE | CHEMBL551978 | Phosphodiesterase 4 inhibitor | INHIBITOR | ChEMBL |
| DYPHYLLINE | CHEMBL1752 | Phosphodiesterase 4 inhibitor | INHIBITOR | ChEMBL |
1 to 10 of 31
See all 31 drugsTrials534
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07566351 | ROFLUMILAST | PHASE2 | ClinicalTrials.gov | |
| NCT07543640 | ROFLUMILAST | PHASE2 | ClinicalTrials.gov | |
| NCT07537751 | CRISABOROLE | ClinicalTrials.gov | ||
| NCT07519174 | CRISABOROLE | ClinicalTrials.gov | ||
| NCT07438509 | CRISABOROLE | PHASE4 | ClinicalTrials.gov | |
| NCT07437534 | CRISABOROLE | PHASE4 | ClinicalTrials.gov | |
| NCT07398651 | APREMILAST | ClinicalTrials.gov | ||
| NCT07367932 | CRISABOROLE | PHASE4 | ClinicalTrials.gov | |
| NCT07366268 | APREMILAST | ClinicalTrials.gov | ||
| NCT07349472 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov |
1 to 10 of 534
See all 534 trialsNIH grants306
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PDE4C papers | Newest fiscal year |
|---|---|---|---|
| ZIAMH002852 | Clinical Evaluation of PET Radiotracers | 3 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 2 | 2025 |
| P30CA042014 | Cancer Center Support Grant | 2 | 2025 |
| P30DK084567 | Mayo Center for Cell Signaling in Gastroenterology | 2 | 2025 |
| ZIAMH002793 | PET Radiopharmaceutical Sciences | 2 | 2025 |
| P01CA108671 | Myeloproliferative Neoplasms-Research Consortium | 1 | 2025 |
| P20GM113226 | Hepatobiology and Toxicology COBRE | 1 | 2025 |
| P30AG050911 | Oklahoma Nathan Shock Center of Excellence in Basic Biology of Aging | 1 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 1 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 1 | 2025 |
1 to 10 of 306Source NIH's project files
See all 306 nih grantsPapers451
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Development of a Model for Predicting Chronological Age Based on DNA Methylation Data from Buccal Swabs Using Ion Torrent S5 Technology. | Int J Mol Sci | 2026 | 42589712 | PubTator, text mining | PubMed |
| DNA Methylation at Core N-Methyl-D-Aspartate (NMDA) Receptor Genes Reveals a Glutamatergic Signature of Aging in Post-COVID Whole Blood With Implications for Long-COVID Neuropsychiatric Sequelae. | Cureus | 2026 | 42471918 | PubTator, text mining | PubMed |
| Early blood DNA methylation patterns associated with glycemic progression in a prospective Indian cohort. | Clin Epigenetics | 2026 | 41992370 | PubTator, text mining | PubMed |
| A targeted epigenetic clock for simultaneous assessment of biological aging and cancer-associated methylation drift. | Clin Epigenetics | 2026 | 41963974 | PubTator, text mining | PubMed |
| Cell-Cell Interactome-Based Pathogenesis and Therapies for Osteosarcoma. | Cells | 2026 | 41892359 | PubTator, text mining | PubMed |
| Examining Epigenetic Age in Women with Different Obesity Conditions Using DNA Methylation at the FHL2 Gene. | Methods Protoc | 2026 | 41874164 | PubTator, text mining | PubMed |
| PDE4C stabilized by ELAVL1 promotes lymph node metastasis in papillary thyroid cancer. | Am J Cancer Res | 2026 | 41868681 | PubTator, text mining | PubMed |
| Biological implications and therapeutic potential of phosphodiesterase inhibitors: A review. | Medicine (Baltimore) | 2026 | 41790675 | PubTator, text mining | PubMed |
| Lifespan-Extending Endogenous Metabolites. | Aging Cell | 2026 | 41527327 | PubTator, text mining | PubMed |
| Biopsy and Blood Gene Expression Distinguish Injury, Subclinical and Clinical Rejection in Kidney Transplant Recipients. | Transplant Direct | 2026 | 41404547 | PubTator, text mining | PubMed |
1 to 10 of 451
See all 451 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5143
GET https://conductscience.org/api/genes/v1/5143/patents?page=2