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PDE4D: phosphodiesterase 4D
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Gene · 5144

Papers2,257

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 2,257

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TitleJournalYearPMIDFound bySource
Epitranscriptomic Regulation of Cardiac Ischemia-Reperfusion Injury: Unveiling the METTL14/IGF2BP1/PDE4D Axis.Korean Circ J202642750131PubTator, text miningPubMed
[Clinical and genetic characteristics of 6 children with acrodysostosis].Zhonghua Er Ke Za Zhi202642742022PubTator, text miningPubMed
Serum N-terminal Pro-B-Type Natriuretic Peptide and Phosphodiesterase 4D Levels in Adults With Overt Hypothyroidism: A Case-Control Study.Cureus202642732212PubTator, text miningPubMed
Large-scale comparative virtual screening identifies novel molecular targets underlying the multi-target activity of quercetin in psoriasis.Inflammopharmacology202642726435PubTator, text miningPubMed
Exploring the molecular mechanisms of Weifuchun in the treatment of chronic atrophic gastritis based on single-cell sequencing and machine learning.J Ethnopharmacol202642716194PubTator, text miningPubMed
Berberine, a natural molecular glue degrader, overcomes CML resistance via TRIM28-mediated HIF1α ubiquitination and subsequent ferroptosis.Cell Rep202642709544PubTator, text miningPubMed
ATP/P2X7 signaling as a potential predictive biomarker for early recurrence of nasal polyps: Correlation with inflammasome activation and epithelial barrier dysfunction.World Allergy Organ J202642707170PubTator, text miningPubMed
A Comprehensive Review of Phosphodiesterases 4 (PDE4) Inhibitors in Clinical Trials.Curr Pharm Des202642515906PubTator, text miningPubMed
Therapeutic potential of pachymic acid in glioma: a comprehensive approach combining experimental validation, network pharmacology, and machine learning.Brain Res202642468874PubTator, text miningPubMed
Design, Synthesis, and Evaluation of Braylin Derivatives as Novel PDE4 Inhibitors with Anti-Inflammatory Effects.Pharmaceutics202642198210PubTator, text miningPubMed
KTX207-mediated PDE4D degradation disrupts tumour cell migration, invasion, and angiogenic potential.Cell Commun Signal202642169031PubTator, text miningPubMed
Natural PDE4 inhibitors from plants: A comprehensive review of discovery, structure-activity relationships, and clinical translation potential.Eur J Med Chem202642166818PubTator, text miningPubMed
PDE4D Mediates the Cardiac Ischemia Reperfusion Injury and Is m6A Modified by METTL14.Korean Circ J202642144760PubTator, text miningPubMed
Design, synthesis, biological evaluation, and molecular dynamics study of asymmetric N-isopropyl-4-piperidone diarylpentanoids as potential anticancer and anti-inflammatory agents.RSC Adv202642080162PubTator, text miningPubMed
Variecolactone, a Natural PDE4 Inhibitor from Marine-Derived Talaromyces sp. ZSD-1, Alleviates Amyloid-β Accumulation and mtDNA Dyshomeostasis via cAMP-PKA-CREB Signaling Pathway.Biomolecules202642072691PubTator, text miningPubMed
Omics-Derived Prognostic Biomarkers in Tongue Squamous Cell Carcinoma: A Systematic Review with Risk-of-Bias Appraisal and Translational Prioritization.Curr Issues Mol Biol202642042050PubTator, text miningPubMed
α-Mangostin protects human brain microvascular endothelial cells from OGD/R-induced damage via regulation of the PDE4D-MAPK pathway.Pathol Res Pract202642033866PubTator, text miningPubMed
Machine learning identifies molecular targets of Di (2-ethylhexyl) phthalate in pulmonary arterial hypertension.Front Bioinform202641938339PubTator, text miningPubMed
Metastasis-Associated Wound Repair Promotes Reciprocal Lung Epithelium Activation and Breast Cancer Metastatic Outgrowth.Cancer Res Commun202641937294PubTator, text miningPubMed
Protein Expression Status of HTR4 and PDE4D Genes in Glial Brain Tumors Followed by the Study of Genomic Instability.Life (Basel)202641900893PubTator, text miningPubMed

gene-search-2026-11-11-0.2.0

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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