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Gene · 5144

PDE4D: phosphodiesterase 4D

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PDE4D: phosphodiesterase 4D. Genes, record 5144. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5144

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Gene

Symbol
PDE4D
HGNC
Name
phosphodiesterase 4D
HGNC
NCBI Gene ID
5144
NCBI Gene
HGNC ID
HGNC:8783
HGNC
Ensembl
ENSG00000113448
NCBI Gene
Aliases
ACRDYS2, DPDE3, HSPDE4D, PDE43, PDE4DN2, STRK1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q084993',5'-cyclic-AMP phosphodiesterase 4D809122Ensembl, GeneID, HGNC

Source UniProt

Patents60

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457738Q08499Espacenet
WO 2025252547 A12025-12-11100Q08499Espacenet
EP 4660322 A12025-12-10100Q08499Espacenet
EP 4641201 A22025-10-296847Q08499Espacenet
WO 2025195968 A12025-09-2511Q08499Espacenet
EP 4620461 A12025-09-2411Q08499Espacenet
JP 2025517969 A2025-06-126847Q08499Espacenet
JP 2025081323 A2025-05-2715Q08499Espacenet
JP 2025032204 A2025-03-1133156Q08499Espacenet
WO 2025016918 A12025-01-23100Q08499Espacenet

1 to 10 of 60

See all 60 patents

Drugs32

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMINOPHYLLINECHEMBL1370561Phosphodiesterase 4 inhibitorINHIBITORChEMBL
AMLEXANOXCHEMBL1096Phosphodiesterase 4 inhibitorINHIBITORChEMBL
APREMILASTCHEMBL514800Phosphodiesterase 4 inhibitorINHIBITORChEMBL
CILOMILASTCHEMBL511115Phosphodiesterase 4 inhibitorINHIBITORChEMBL
CRISABOROLECHEMBL484785Phosphodiesterase 4 inhibitorINHIBITORChEMBL
DIFAMILASTCHEMBL3989968Phosphodiesterase 4 inhibitorINHIBITORChEMBL
DIPYRIDAMOLECHEMBL9323',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL
DOVRAMILASTCHEMBL4297460Phosphodiesterase 4 inhibitorINHIBITORChEMBL
DROTAVERINECHEMBL551978Phosphodiesterase 4 inhibitorINHIBITORChEMBL
DYPHYLLINECHEMBL1752Phosphodiesterase 4 inhibitorINHIBITORChEMBL

1 to 10 of 32

See all 32 drugs

Trials540

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,937

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDE4D papersNewest fiscal year
P30CA008748Cancer Center Support Grant72025
P30CA016672Cancer Center Support Grant72025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes62025
P30ES007048Environmental Exposures, Host Factors and Human Disease62025
UL1TR001863Yale Clinical and Translational Science Award62025
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors52025
T32HL007427SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES52025
P30CA013148Comprehensive Cancer Center Support Grant42025
P30CA076292Moffitt Cancer Center Support Grant42025
R01DK073368Mechanisms of Compartmentalized cAMP Signaling42025

1 to 10 of 1,937Source NIH's project files

See all 1,937 nih grants

Papers2,257

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Epitranscriptomic Regulation of Cardiac Ischemia-Reperfusion Injury: Unveiling the METTL14/IGF2BP1/PDE4D Axis.Korean Circ J202642750131PubTator, text miningPubMed
[Clinical and genetic characteristics of 6 children with acrodysostosis].Zhonghua Er Ke Za Zhi202642742022PubTator, text miningPubMed
Serum N-terminal Pro-B-Type Natriuretic Peptide and Phosphodiesterase 4D Levels in Adults With Overt Hypothyroidism: A Case-Control Study.Cureus202642732212PubTator, text miningPubMed
Large-scale comparative virtual screening identifies novel molecular targets underlying the multi-target activity of quercetin in psoriasis.Inflammopharmacology202642726435PubTator, text miningPubMed
Exploring the molecular mechanisms of Weifuchun in the treatment of chronic atrophic gastritis based on single-cell sequencing and machine learning.J Ethnopharmacol202642716194PubTator, text miningPubMed
Berberine, a natural molecular glue degrader, overcomes CML resistance via TRIM28-mediated HIF1α ubiquitination and subsequent ferroptosis.Cell Rep202642709544PubTator, text miningPubMed
ATP/P2X7 signaling as a potential predictive biomarker for early recurrence of nasal polyps: Correlation with inflammasome activation and epithelial barrier dysfunction.World Allergy Organ J202642707170PubTator, text miningPubMed
A Comprehensive Review of Phosphodiesterases 4 (PDE4) Inhibitors in Clinical Trials.Curr Pharm Des202642515906PubTator, text miningPubMed
Therapeutic potential of pachymic acid in glioma: a comprehensive approach combining experimental validation, network pharmacology, and machine learning.Brain Res202642468874PubTator, text miningPubMed
Design, Synthesis, and Evaluation of Braylin Derivatives as Novel PDE4 Inhibitors with Anti-Inflammatory Effects.Pharmaceutics202642198210PubTator, text miningPubMed

1 to 10 of 2,257

See all 2,257 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5144

GET https://conductscience.org/api/genes/v1/5144/patents?page=2