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Gene · 51441

YTHDF2: YTH N6-methyladenosine RNA binding protein F2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. YTHDF2: YTH N6-methyladenosine RNA binding protein F2. Genes, record 51441. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51441

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Gene

Symbol
YTHDF2
HGNC
Name
YTH N6-methyladenosine RNA binding protein F2
HGNC
NCBI Gene ID
51441
NCBI Gene
HGNC ID
HGNC:31675
HGNC
Ensembl
ENSG00000198492
NCBI Gene
Aliases
CAHL, DF2, HGRG8, NY-REN-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y5A9YTH domain-containing family protein 257929Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1470089Q9Y5A9Espacenet
JP 2026004568 A2026-01-1470092Q9Y5A9Espacenet
EP 4650780 A22025-11-199375Q9Y5A9Espacenet
EP 4641201 A22025-10-299619Q9Y5A9Espacenet
WO 2025217591 A12025-10-16106Q9Y5A9Espacenet
JP 2025517969 A2025-06-129619Q9Y5A9Espacenet
JP 2025517970 A2025-06-129375Q9Y5A9Espacenet
JP 2023529460 A2023-07-1019Q9Y5A9Espacenet
US 11446398 B22022-09-2098266Q9Y5A9Espacenet
US 11446398 B22022-09-2098268Q9Y5A9Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants996

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleYTHDF2 papersNewest fiscal year
RM1HG008935Center for dynamic RNA epitranscriptomes - Renewal312025
R01CA186702Mechanisms of epitranscriptomic regulation in cancer102025
R01CA271497The role and therapeutic potential of IGF2BP2 in MLL-rearranged leukemia82025
R01AI125416Defining the role of the RNA modification N6-methyladenosine during Flaviviridae virus infection72025
P30CA014599Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant62025
R01CA096512Cell model for KSHV infection and genetic manipulation62025
R01CA124332Regulation of KSHV replication by N6-methyladenosine (m6A)62025
R35NS111631New mechanisms and technologies for understanding post-transcriptional gene regulation in neurons62025
P30AI064518Center for AIDS Research52025

1 to 10 of 996Source NIH's project files

See all 996 nih grants

Papers3,768

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Single residues within the YTHDF intrinsically disordered region control m 6 A-dependent mRNA decay.bioRxiv202642818126PubTator, text miningPubMed
From translation milestones to clinical breakthroughs: Decision-making hubs and translational strategies for RNA-binding proteins in the immunotherapy of haematological malignancies.Crit Rev Oncol Hematol202642805357PubTator, text miningPubMed
Epitranscriptomic regulation of Notch signaling.Cell Signal202642800623PubTator, text miningPubMed
FTO-Driven m6A Demethylation of TNC Promotes Epithelial-Mesenchymal Transition and Gastric Cancer Metastasis.Biomedicines202642792700PubTator, text miningPubMed
Zearalenone suppresses pituitary follicle-stimulating hormone synthesis via ALKBH5-YTHDF2-SMAD4 axis.J Hazard Mater202642772075PubTator, text miningPubMed
Destabilization of hsa_circ_0015508 by YTHDF2 Enhances miR-496-Mediated FOXN3 Suppression to Drive Nasopharyngeal Carcinoma Progression.Oncol Res202642769473PubTator, text miningPubMed
Targeting the SETD2-FTO-KIT pathway as a pharmacological strategy for TKI-refractory GIST.Acta Pharm Sin B202642764990PubTator, text miningPubMed
Allosteric modulation of YTHDFs by ellagic acid suppresses triple-negative breast cancer via non-canonical activation of the HIF-1α pathway.Cell Rep Med202642748913PubTator, text miningPubMed
circNfix attenuates acute kidney injury by driving m6A-dependent degradation of YTHDF2 to stabilize DAPK2 mRNA.Clin Sci (Lond)202642742123PubTator, text miningPubMed
METTL14 alleviates pyroptosis of placental trophoblasts in gestational diabetes mellitus through the lncRNA MEG8/WNT7A axis via m6A modification.Funct Integr Genomics202642726311PubTator, text miningPubMed

1 to 10 of 3,768

See all 3,768 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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