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Gene · 51514

DTL: denticleless E3 ubiquitin protein ligase adapter

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DTL: denticleless E3 ubiquitin protein ligase adapter. Genes, record 51514. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51514

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Gene

Symbol
DTL
HGNC
Name
denticleless E3 ubiquitin protein ligase adapter
HGNC
NCBI Gene ID
51514
NCBI Gene
HGNC ID
HGNC:30288
HGNC
Ensembl
ENSG00000143476
NCBI Gene
Aliases
CDT2, DCAF2, L2DTL, RAMP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NZJ0Denticleless protein homolog7305Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1443591Q9NZJ0Espacenet
EP 4650780 A22025-11-198146Q9NZJ0Espacenet
EP 4641201 A22025-10-298303Q9NZJ0Espacenet
EP 4641202 A22025-10-295374Q9NZJ0Espacenet
JP 2025517969 A2025-06-128303Q9NZJ0Espacenet
JP 2025517970 A2025-06-128146Q9NZJ0Espacenet
KR 1020250017231 A2025-02-045374Q9NZJ0Espacenet
US 11446398 B22022-09-2023850Q9NZJ0Espacenet
JP 2022524081 A2022-04-27126821Q9NZJ0Espacenet
JP 2019054813 A2019-04-11224026Q9NZJ0Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants854

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDTL papersNewest fiscal year
P30CA044579University of Virginia Cancer Center Support Grant102025
T32CA009109Cancer Research Training Program: From Molecular Mechanisms to Therapeutic Strategies72025
R01HD060860Adrenomedullin Signaling at the Maternal-Fetal Interface62025
P30CA008748Cancer Center Support Grant52025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control52025
T32GM136640Tri-institutional PhD Program in Chemical Biology42025
ZIABC010411Initiation of DNA Replication in Mammalian Cells42025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant22025
P30CA016058Cancer Center Support Grant22025
P30CA016086Cancer Center Support Grant22025

1 to 10 of 854Source NIH's project files

See all 854 nih grants

Papers1,470

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Ferroptosis, immune activation and MASH-related HCC.Gut202642722415PubTator, text miningPubMed
Colchicine enhances macrophage cholesterol efflux by targeting DTL-mediated ubiquitination and degradation of ABCA1.RMD Open202642419788PubTator, text miningPubMed
Rare protein-coding variation and the genetic architecture of height in >1.4 million individuals.medRxiv202642396316PubTator, text miningPubMed
Psychometric properties, pragmatic screening cut-offs, and feasibility of two Clock Drawing Test formats in older psychiatric outpatients: Associations with MMSE and HDS-R.PCN Rep202642256356PubTator, text miningPubMed
Schwann-endothelial crosstalk in neurovascularized cell sheets induced host CGRP release to drive mandibular bone regeneration.J Orthop Translat202641836567PubTator, text miningPubMed
The Neuroimmune Axis in Gastric Cancer: Bridging Neural Regulation, Tumor Microenvironment, and Immunotherapy.Oncol Res202641799505PubTator, text miningPubMed
Pro-tumourigenic effects of DCAF13 on the progression of colorectal cancer.Oncol Lett202641797888PubTator, text miningPubMed
Integrated bioinformatics analysis and experimental validation reveal Pevonedistat as a promising therapeutic agent modulating the CRL4-DTL-p21/p53 axis in nasopharyngeal carcinoma.Hereditas202641794796PubTator, text miningPubMed
Construction and validation of a novel diagnostic model for esophageal squamous cell carcinoma: an integrated analysis of multi-omics data.Front Immunol202641766902PubTator, text miningPubMed
Gender-Specific Gene Regulation of Ferroptosis in Non-Utilized Liver Donors.Genes (Basel)202641751603PubTator, text miningPubMed

1 to 10 of 1,470

See all 1,470 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/51514

GET https://conductscience.org/api/genes/v1/51514/patents