Gene · 51514
DTL: denticleless E3 ubiquitin protein ligase adapter
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DTL: denticleless E3 ubiquitin protein ligase adapter. Genes, record 51514. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51514
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NZJ0 | Denticleless protein homolog | 730 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents16
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 43591 | Q9NZJ0 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8146 | Q9NZJ0 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8303 | Q9NZJ0 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 5374 | Q9NZJ0 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8303 | Q9NZJ0 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8146 | Q9NZJ0 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 5374 | Q9NZJ0 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 23850 | Q9NZJ0 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 126821 | Q9NZJ0 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 224026 | Q9NZJ0 | Espacenet |
1 to 10 of 16
See all 16 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants854
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DTL papers | Newest fiscal year |
|---|---|---|---|
| P30CA044579 | University of Virginia Cancer Center Support Grant | 10 | 2025 |
| T32CA009109 | Cancer Research Training Program: From Molecular Mechanisms to Therapeutic Strategies | 7 | 2025 |
| R01HD060860 | Adrenomedullin Signaling at the Maternal-Fetal Interface | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 5 | 2025 |
| T32GM136640 | Tri-institutional PhD Program in Chemical Biology | 4 | 2025 |
| ZIABC010411 | Initiation of DNA Replication in Mammalian Cells | 4 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 2 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 2 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 854Source NIH's project files
See all 854 nih grantsPapers1,470
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Ferroptosis, immune activation and MASH-related HCC. | Gut | 2026 | 42722415 | PubTator, text mining | PubMed |
| Colchicine enhances macrophage cholesterol efflux by targeting DTL-mediated ubiquitination and degradation of ABCA1. | RMD Open | 2026 | 42419788 | PubTator, text mining | PubMed |
| Rare protein-coding variation and the genetic architecture of height in >1.4 million individuals. | medRxiv | 2026 | 42396316 | PubTator, text mining | PubMed |
| Psychometric properties, pragmatic screening cut-offs, and feasibility of two Clock Drawing Test formats in older psychiatric outpatients: Associations with MMSE and HDS-R. | PCN Rep | 2026 | 42256356 | PubTator, text mining | PubMed |
| Schwann-endothelial crosstalk in neurovascularized cell sheets induced host CGRP release to drive mandibular bone regeneration. | J Orthop Translat | 2026 | 41836567 | PubTator, text mining | PubMed |
| The Neuroimmune Axis in Gastric Cancer: Bridging Neural Regulation, Tumor Microenvironment, and Immunotherapy. | Oncol Res | 2026 | 41799505 | PubTator, text mining | PubMed |
| Pro-tumourigenic effects of DCAF13 on the progression of colorectal cancer. | Oncol Lett | 2026 | 41797888 | PubTator, text mining | PubMed |
| Integrated bioinformatics analysis and experimental validation reveal Pevonedistat as a promising therapeutic agent modulating the CRL4-DTL-p21/p53 axis in nasopharyngeal carcinoma. | Hereditas | 2026 | 41794796 | PubTator, text mining | PubMed |
| Construction and validation of a novel diagnostic model for esophageal squamous cell carcinoma: an integrated analysis of multi-omics data. | Front Immunol | 2026 | 41766902 | PubTator, text mining | PubMed |
| Gender-Specific Gene Regulation of Ferroptosis in Non-Utilized Liver Donors. | Genes (Basel) | 2026 | 41751603 | PubTator, text mining | PubMed |
1 to 10 of 1,470
See all 1,470 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/51514
GET https://conductscience.org/api/genes/v1/51514/patents