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Gene · 51548

SIRT6: sirtuin 6

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. SIRT6: sirtuin 6. Genes, record 51548. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/51548

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
SIRT6
HGNC
Name
sirtuin 6
HGNC
NCBI Gene ID
51548
NCBI Gene
HGNC ID
HGNC:14934
HGNC
Ensembl
ENSG00000077463
NCBI Gene
Aliases
SIR2L6, hSIRT6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8N6T7NAD-dependent protein deacylase sirtuin-635545Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2025541838 A2025-12-231Q8N6T7Espacenet
EP 4650780 A22025-11-196262Q8N6T7Espacenet
JP 2025169942 A2025-11-141284Q8N6T7Espacenet
JP 2025517970 A2025-06-126262Q8N6T7Espacenet
EP 4491229 A22025-01-15283Q8N6T7Espacenet
WO 2024230934 A12024-11-14408Q8N6T7Espacenet
JP 2024518665 A2024-05-0123Q8N6T7Espacenet
US 11446398 B22022-09-2079446Q8N6T7Espacenet
JP 2022524081 A2022-04-27182417Q8N6T7Espacenet
US 10772975 B22020-09-151284Q8N6T7Espacenet

1 to 10 of 32

See all 32 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,934

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
P01AG047200Comparative genomics of longevity and Alzheimer's disease232025
P01AG051449Role of Retrotransposon Activity in Neurodegeneration and Alzheimer's Disease102025
P30CA008748Cancer Center Support Grant82025
P30CA016672Cancer Center Support Grant82025
R37AG046320Regulation of epigenome stability by SIRT6 during Aging72025
ZIAAG000295Immobilized Proteins In Drug Discovery72025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center62025
P30AG028716Duke Claude D. Pepper Older Americans Independence Center52025
P30DK097512Indiana Diabetes Research Center52025
P30ES001247Environmental Agents as Modulators of Disease Processes52025

1 to 10 of 1,934Source NIH's project files

See all 1,934 nih grants

Papers4,574

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42813062PubTator, text miningPubMed
42793104PubTator, text miningPubMed
42775172PubTator, text miningPubMed
42764862PubTator, text miningPubMed
42727479PubTator, text miningPubMed
42692759PubTator, text miningPubMed
42676034PubTator, text miningPubMed
42664152PubTator, text miningPubMed
42653915PubTator, text miningPubMed
42644057PubTator, text miningPubMed

1 to 10 of 4,574

See all 4,574 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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