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PDGFRA: platelet derived growth factor receptor alpha

1 protein, 207 patents, 34 drugs, 1,431 trials, 8,626 NIH grants and 19,704 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPDGFRAHGNC
Nameplatelet derived growth factor receptor alphaHGNC
NCBI Gene ID5156NCBI Gene
HGNC IDHGNC:8803HGNC
EnsemblENSG00000134853NCBI Gene
AliasesCD140A, CD140a, GAS9, PDGFR-2, PDGFR2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P16234Platelet-derived growth factor receptor alpha1,08915Ensembl, GeneID, HGNCUniProt

Patents 207

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4830719 A22026-10-2813P16234Espacenet
JP 2026120541 A2026-07-2253P16234Espacenet
JP 2026090361 A2026-06-0213P16234Espacenet
JP 2026082857 A2026-05-1953P16234Espacenet
EP 4650780 A22025-11-191629P16234Espacenet
EP 4641201 A22025-10-291234P16234Espacenet
JP 2025163070 A2025-10-28388P16234Espacenet
JP 2025147176 A2025-10-0610192P16234Espacenet
JP 2025529142 A2025-09-043429P16234Espacenet
JP 2025529142 A2025-09-047307P16234Espacenet

Drugs 34

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMUVATINIBCHEMBL2103851Platelet-derived growth factor receptor alpha inhibitorINHIBITORChEMBL
AVAPRITINIBCHEMBL4204794Platelet-derived growth factor receptor alpha inhibitorINHIBITORChEMBL
BECAPLERMINCHEMBL1201556Platelet-derived growth factor receptor agonistAGONISTChEMBL
CEDIRANIBCHEMBL491473Platelet-derived growth factor receptor inhibitorINHIBITORChEMBL
CRENOLANIBCHEMBL2105728Platelet-derived growth factor receptor inhibitorINHIBITORChEMBL
DOVITINIBCHEMBL522892Platelet-derived growth factor receptor inhibitorINHIBITORChEMBL
ENMD-981693CHEMBL52885Platelet-derived growth factor receptor inhibitorINHIBITORChEMBL
FAMITINIBCHEMBL1278146Platelet-derived growth factor receptor inhibitorINHIBITORChEMBL
FORETINIBCHEMBL1230609Platelet-derived growth factor receptor inhibitorINHIBITORChEMBL
ILORASERTIBCHEMBL1980297Platelet-derived growth factor receptor inhibitorINHIBITORChEMBL

Trials 1431

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07583589NINTEDANIBPHASE2ClinicalTrials.gov
NCT07572695MIDOSTAURINClinicalTrials.gov
NCT07559864REGORAFENIBPHASE2ClinicalTrials.gov
NCT07537985REGORAFENIBClinicalTrials.gov
NCT07517653FAMITINIBPHASE2ClinicalTrials.gov
NCT07514455REGORAFENIBPHASE2ClinicalTrials.gov
NCT07514429REGORAFENIBPHASE2ClinicalTrials.gov
NCT07501351REGORAFENIBPHASE2ClinicalTrials.gov
NCT07495579REGORAFENIBPHASE2ClinicalTrials.gov
NCT07491523NINTEDANIBClinicalTrials.gov

NIH grants 8626

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant2452,025NIH's project files
P30CA016672Cancer Center Support Grant2292,025NIH's project files
R01CA102613Molecular Mechanisms in Gastrointestinal Stromal Tumor542,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)452,025NIH's project files
ZIAAI001130Eosinophils and Eosinophil Activation in the Pathogenesis of Human Disease402,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase372,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award342,025NIH's project files
P50CA097257Brain Tumor SPORE Grant332,025NIH's project files
P01CA096832NORMAL & NEOPLASTIC GROWTH IN THE BRAIN312,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant312,025NIH's project files

Papers 19704

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823566PubTator, text miningPubMed
42819738PubTator, text miningPubMed
42817679PubTator, text miningPubMed
42810841PubTator, text miningPubMed
42793025PubTator, text miningPubMed
42792247PubTator, text miningPubMed
42789045PubTator, text miningPubMed
42786078PubTator, text miningPubMed
42783456PubTator, text miningPubMed
42783422PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license