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Gene · 51564

HDAC7: histone deacetylase 7

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HDAC7: histone deacetylase 7. Genes, record 51564. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51564

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Gene

Symbol
HDAC7
HGNC
Name
histone deacetylase 7
HGNC
NCBI Gene ID
51564
NCBI Gene
HGNC ID
HGNC:14067
HGNC
Ensembl
ENSG00000061273
NCBI Gene
Aliases
DKFZP586J0917, HD7, HD7A, HDAC7A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8WUI4Histone deacetylase 79526Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1913283Q8WUI4Espacenet
EP 4641201 A22025-10-2915079Q8WUI4Espacenet
EP 4626460 A12025-10-0810Q8WUI4Espacenet
JP 2025517969 A2025-06-1215079Q8WUI4Espacenet
JP 2025517970 A2025-06-1213283Q8WUI4Espacenet
JP 2024123008 A2024-09-106487Q8WUI4Espacenet
US 11446398 B22022-09-2038631Q8WUI4Espacenet
JP 2022524081 A2022-04-27141602Q8WUI4Espacenet
US 10501513 B22019-12-106487Q8WUI4Espacenet
JP 2017197545 A2017-11-0231188Q8WUI4Espacenet

1 to 10 of 25

See all 25 patents

Drugs12

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABEXINOSTATCHEMBL2103863Histone deacetylase inhibitorINHIBITORChEMBL
BELINOSTATCHEMBL408513Histone deacetylase inhibitorINHIBITORChEMBL
CUDC-101CHEMBL598797Histone deacetylase inhibitorINHIBITORChEMBL
ENTINOSTATCHEMBL27759Histone deacetylase inhibitorINHIBITORChEMBL
FIMEPINOSTATCHEMBL3622533Histone deacetylase inhibitorINHIBITORChEMBL
GIVINOSTATCHEMBL1213492Histone deacetylase inhibitorINHIBITORChEMBL
GIVINOSTAT HYDROCHLORIDECHEMBL6068400Histone deacetylase inhibitorINHIBITORChEMBL
PANOBINOSTATCHEMBL483254Histone deacetylase inhibitorINHIBITORChEMBL
PANOBINOSTAT LACTATECHEMBL3545368Histone deacetylase inhibitorINHIBITORChEMBL
QUISINOSTATCHEMBL2105763Histone deacetylase inhibitorINHIBITORChEMBL

1 to 10 of 12

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Trials389

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07492394ENTINOSTATPHASE2ClinicalTrials.gov
NCT07441486ENTINOSTATPHASE2ClinicalTrials.gov
NCT07330544ENTINOSTATPHASE2ClinicalTrials.gov
NCT07261592ENTINOSTATPHASE1/PHASE2ClinicalTrials.gov
NCT07235618ENTINOSTATPHASE2ClinicalTrials.gov
NCT06824662QUISINOSTATEARLY_PHASE1ClinicalTrials.gov
NCT06769633GIVINOSTAT HYDROCHLORIDEPHASE2ClinicalTrials.gov
NCT06561048BELINOSTATPHASE3ClinicalTrials.gov
NCT06406465BELINOSTATPHASE2ClinicalTrials.gov
NCT06240520PANOBINOSTATPHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 389

See all 389 trials

NIH grants1,540

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHDAC7 papersNewest fiscal year
P30CA008748Cancer Center Support Grant142025
R01GM049758Structure and Function of Metalloenzymes112025
P30CA016672Cancer Center Support Grant102025
P30CA043703Case Comprehensive Cancer Center Support Grant92025
R01HL095524Modulation of Lung Disease by Genetic/Epigenetic Profiling62025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology52025
R35GM131821Chemical Approaches to Study Protein Post-translational Modifications52025
P30CA016056Roswell Park Cancer Center Support Grant42025
P30CA013148Comprehensive Cancer Center Support Grant32025
P30CA021765Cancer Center Support Grant (CCSG)32025

1 to 10 of 1,540Source NIH's project files

See all 1,540 nih grants

Papers2,197

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart.J Precis Med (Amst)202642644057PubTator, text miningPubMed
Histone Deacetylase 7 protects against pathologic cardiac hypertrophy.J Mol Cell Cardiol202642250622PubTator, text miningPubMed
HDAC7-Induced Epigenetic Repression Modulates ATF3 Functional Plasticity in Colorectal Cancer Pathogenesis.Int J Biol Sci202642157949PubTator, text miningPubMed
Epigenetic remodeling of the nasal epithelium in chronic rhinosinusitis: Histone deacetylase 7 (HDAC7) mediates type 2 inflammation.Ann Allergy Asthma Immunol202642103401PubTator, text miningPubMed
EGFR-19del nuclear translocation increases HDAC7 expression inhibiting the Hippo pathway and exacerbating TKI resistance in lung adenocarcinoma.Theranostics202642094614PubTator, text miningPubMed
Altered HDAC expression is associated with CYP24A1-mediated vitamin D deficiency in gestational diabetes mellitus.Epigenomics202642089337PubTator, text miningPubMed
USP10 deubiquitinase: Physiological function, diseases and therapeutic target (Review).Int J Mol Med202641891958PubTator, text miningPubMed
Global molecular landscape of early MASLD progression in human obesity.Elife202641870035PubTator, text miningPubMed
HDAC7 is a key factor for the germinal center reaction and its underexpression is associated with DLBCL prognosis.J Immunol202641847858PubTator, text miningPubMed
Growth factor applications and clinical translation: advances and challenges.Ann Med202641837883PubTator, text miningPubMed

1 to 10 of 2,197

See all 2,197 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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