Gene · 5160
PDHA1: pyruvate dehydrogenase E1 subunit alpha 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PDHA1: pyruvate dehydrogenase E1 subunit alpha 1. Genes, record 5160. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5160
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P08559 | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 390 | 9 | Ensembl, GeneID, HGNC |
Source UniProt
Patents40
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 373 | P08559 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 60564 | P08559 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 12646 | P08559 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 10204 | P08559 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7310 | P08559 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7310 | P08559 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 12646 | P08559 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 10204 | P08559 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 10204 | P08559 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 10211 | P08559 | Espacenet |
1 to 10 of 40
See all 40 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,122
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PDHA1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 5 | 2025 |
| R01CA140515 | Signaling importance of ‘functionless’ lyso-PAF, an inactive form of platelet activating factor, in melanoma with mutant Nras | 5 | 2025 |
| P30CA012197 | Cancer Center Support Grant | 4 | 2025 |
| P01CA120964 | Molecular Pathogenesis of the Hamartoma Syndromes | 3 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 3 | 2025 |
| P30CA177558 | University of Kentucky Markey Cancer Center – Cancer Center Support Grant | 3 | 2025 |
| P51OD011104 | Tulane National Primate Research Center | 3 | 2025 |
| R35GM134963 | Fluorescence tools that illuminate biology and inspire translation | 3 | 2025 |
1 to 10 of 1,122Source NIH's project files
See all 1,122 nih grantsPapers2,019
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| SUMOylation of PGAM2 regulates mitochondrial metabolism and cuproptosis-related damage during boar sperm cryoinjury. | Theriogenology | 2027 | 42810240 | PubTator, text mining | PubMed |
| LINC00861 protects against sepsis-associated acute kidney injury by regulating apoptosis and inflammation via miR-151a-3p/PDHA1 Axis. | Ann Agric Environ Med | 2026 | 42802968 | PubTator, text mining | PubMed |
| KDM4B Maintains Pyruvate Dehydrogenase Complex Expression to Support Mitochondrial Metabolism and Survival in Cancer Cells. | Epigenomes | 2026 | 42782835 | PubTator, text mining | PubMed |
| A Lipoylation-PDH-TCA Transcriptional Deficit in the Alzheimer's Disease Cortex - Donor-level Multi-cohort Evidence with Neuronal-composition, Disease-specificity and Matched-null Controls. | J Mol Neurosci | 2026 | 42752765 | PubTator, text mining | PubMed |
| A new role of iridium(III) complexes in regulating pluripotency acquisition via mitochondrial remodulation. | Sci China Life Sci | 2026 | 42734690 | PubTator, text mining | PubMed |
| A novel approach to reverse Warburg metabolism in patients with recurrent glioblastoma: A phase II pharmacodynamic study of dichloroacetate. | Neurooncol Adv | 2026 | 42719375 | PubTator, text mining | PubMed |
| KRAS/ERK2-driven stabilization of AARS1 reprograms tumor metabolism and confers Sorafenib resistance in lung adenocarcinoma. | Cell Death Differ | 2026 | 42716955 | PubTator, text mining | PubMed |
| Dysregulated Acetate Metabolism and Cholesterol Biosynthesis in Cumulus Cells of Women with Polycystic Ovary Syndrome. | Cell J | 2026 | 42634992 | PubTator, text mining | PubMed |
| PDHA1 Hyperactivation Orchestrates Metabolic Reprogramming Promoting Endothelial Senescence. | Research (Wash D C) | 2026 | 42625807 | PubTator, text mining | PubMed |
| Crotonylation of ACAT1 K181 contributes to radioresistance by impacting lactate metabolism. | Commun Biol | 2026 | 42587030 | PubTator, text mining | PubMed |
1 to 10 of 2,019
See all 2,019 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5160
GET https://conductscience.org/api/genes/v1/5160/patents?page=2