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Gene · 5160

PDHA1: pyruvate dehydrogenase E1 subunit alpha 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PDHA1: pyruvate dehydrogenase E1 subunit alpha 1. Genes, record 5160. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5160

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Gene

Symbol
PDHA1
HGNC
Name
pyruvate dehydrogenase E1 subunit alpha 1
HGNC
NCBI Gene ID
5160
NCBI Gene
HGNC ID
HGNC:8806
HGNC
Ensembl
ENSG00000131828
NCBI Gene
Aliases
E1alpha, PDHA, PDHAD, PDHCE1A, PHE1A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P08559Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial3909Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21373P08559Espacenet
JP 2026004568 A2026-01-1460564P08559Espacenet
EP 4650780 A22025-11-1912646P08559Espacenet
JP 2025147176 A2025-10-0610204P08559Espacenet
JP 2025529142 A2025-09-047310P08559Espacenet
US 12371689 B22025-07-297310P08559Espacenet
JP 2025517970 A2025-06-1212646P08559Espacenet
JP 2025028160 A2025-02-2810204P08559Espacenet
KR 1020250010750 A2025-01-2110204P08559Espacenet
JP 2024109657 A2024-08-1410211P08559Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,122

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDHA1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant72025
P30CA008748Cancer Center Support Grant62025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control52025
R01CA140515Signaling importance of ‘functionless’ lyso-PAF, an inactive form of platelet activating factor, in melanoma with mutant Nras52025
P30CA012197Cancer Center Support Grant42025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes32025
P30CA014051Cancer Center Support (Core) Grant32025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant32025
P51OD011104Tulane National Primate Research Center32025
R35GM134963Fluorescence tools that illuminate biology and inspire translation32025

1 to 10 of 1,122Source NIH's project files

See all 1,122 nih grants

Papers2,019

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
SUMOylation of PGAM2 regulates mitochondrial metabolism and cuproptosis-related damage during boar sperm cryoinjury.Theriogenology202742810240PubTator, text miningPubMed
LINC00861 protects against sepsis-associated acute kidney injury by regulating apoptosis and inflammation via miR-151a-3p/PDHA1 Axis.Ann Agric Environ Med202642802968PubTator, text miningPubMed
KDM4B Maintains Pyruvate Dehydrogenase Complex Expression to Support Mitochondrial Metabolism and Survival in Cancer Cells.Epigenomes202642782835PubTator, text miningPubMed
A Lipoylation-PDH-TCA Transcriptional Deficit in the Alzheimer's Disease Cortex - Donor-level Multi-cohort Evidence with Neuronal-composition, Disease-specificity and Matched-null Controls.J Mol Neurosci202642752765PubTator, text miningPubMed
A new role of iridium(III) complexes in regulating pluripotency acquisition via mitochondrial remodulation.Sci China Life Sci202642734690PubTator, text miningPubMed
A novel approach to reverse Warburg metabolism in patients with recurrent glioblastoma: A phase II pharmacodynamic study of dichloroacetate.Neurooncol Adv202642719375PubTator, text miningPubMed
KRAS/ERK2-driven stabilization of AARS1 reprograms tumor metabolism and confers Sorafenib resistance in lung adenocarcinoma.Cell Death Differ202642716955PubTator, text miningPubMed
Dysregulated Acetate Metabolism and Cholesterol Biosynthesis in Cumulus Cells of Women with Polycystic Ovary Syndrome.Cell J202642634992PubTator, text miningPubMed
PDHA1 Hyperactivation Orchestrates Metabolic Reprogramming Promoting Endothelial Senescence.Research (Wash D C)202642625807PubTator, text miningPubMed
Crotonylation of ACAT1 K181 contributes to radioresistance by impacting lactate metabolism.Commun Biol202642587030PubTator, text miningPubMed

1 to 10 of 2,019

See all 2,019 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5160

GET https://conductscience.org/api/genes/v1/5160/patents?page=2