ConductScience.org, home

Library / Genes

PDK1: pyruvate dehydrogenase kinase 1

1 protein, 55 patents, 1 drug, 1 trial, 6,139 NIH grants and 11,940 papers.

Gene 6

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPDK1HGNC
Namepyruvate dehydrogenase kinase 1HGNC
NCBI Gene ID5163NCBI Gene
HGNC IDHGNC:8809HGNC
EnsemblENSG00000152256NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q15118[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial4365Ensembl, GeneID, HGNCUniProt

Patents 55

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-193150Q15118Espacenet
JP 2025157475 A2025-10-1560Q15118Espacenet
EP 4620519 A22025-09-248Q15118Espacenet
EP 4620520 A22025-09-248Q15118Espacenet
EP 4620521 A22025-09-248Q15118Espacenet
JP 2025517970 A2025-06-123150Q15118Espacenet
JP 2024123008 A2024-09-107977Q15118Espacenet
JP 2024123008 A2024-09-107979Q15118Espacenet
US 11860162 B22024-01-021583Q15118Espacenet
JP 2022544882 A2022-10-2161Q15118Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
SODIUM DICHLOROACETATECHEMBL306823Pyruvate dehydrogenase kinase inhibitorINHIBITORChEMBL

Trials 1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT00004490SODIUM DICHLOROACETATEPHASE3ClinicalTrials.gov

NIH grants 6139

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1262,025NIH's project files
P30CA008748Cancer Center Support Grant602,025NIH's project files
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes222,025NIH's project files
P30CA068485Cancer Center Support Grant182,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant152,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase142,025NIH's project files
P30CA006973Regional Oncology Research Center142,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program142,025NIH's project files
P30CA016520Abramson Cancer Center Support Grant132,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant132,025NIH's project files

Papers 11940

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42810159PubTator, text miningPubMed
42809633PubTator, text miningPubMed
42789062PubTator, text miningPubMed
42782835PubTator, text miningPubMed
42774692PubTator, text miningPubMed
42745287PubTator, text miningPubMed
42716156PubTator, text miningPubMed
42689220PubTator, text miningPubMed
42649850PubTator, text miningPubMed
42586446PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license