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Gene · 5164

PDK2: pyruvate dehydrogenase kinase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PDK2: pyruvate dehydrogenase kinase 2. Genes, record 5164. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5164

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Gene

Symbol
PDK2
HGNC
Name
pyruvate dehydrogenase kinase 2
HGNC
NCBI Gene ID
5164
NCBI Gene
HGNC ID
HGNC:8810
HGNC
Ensembl
ENSG00000005882
NCBI Gene
Aliases
PDHK2, PDKII
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15119[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial40738Ensembl, GeneID, HGNC

Source UniProt

Patents34

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1914486Q15119Espacenet
EP 4641201 A22025-10-2916978Q15119Espacenet
JP 2025517969 A2025-06-1216978Q15119Espacenet
JP 2025517970 A2025-06-1214486Q15119Espacenet
JP 2024123008 A2024-09-107983Q15119Espacenet
US 11446398 B22022-09-2070332Q15119Espacenet
JP 2022524081 A2022-04-27173303Q15119Espacenet
US 10501513 B22019-12-107983Q15119Espacenet
US 10131691 B22018-11-2012Q15119Espacenet
JP 2017197545 A2017-11-0232684Q15119Espacenet

1 to 10 of 34

See all 34 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
SODIUM DICHLOROACETATECHEMBL306823Pyruvate dehydrogenase kinase inhibitorINHIBITOR

Source ChEMBL

Trials1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first posted
NCT00004490SODIUM DICHLOROACETATEPHASE3

NIH grants883

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDK2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant72025
P30CA016058Cancer Center Support Grant62025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant32025
P01AG026572Perimenopause in Brain Aging and Alzheimer's Disease22025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes22025
P30CA008748Cancer Center Support Grant22025
P30CA010815Consolidated Basic Cancer Research Program22025
P30CA014195Cancer Center Support Grant (CCSG)22025
P30CA016086Cancer Center Support Grant22025
P30CA021765Cancer Center Support Grant (CCSG)22025

1 to 10 of 883Source NIH's project files

See all 883 nih grants

Papers1,365

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Particulate Matter Exposure and Diabetic Kidney Dysfunction: Insights from Integrated Transcriptomic and Bioinformatics Analyses.Int J Mol Sci202642737513PubTator, text miningPubMed
The tire antioxidant derivative 6PPD-quinone exacerbates IBD by targeting NR1H4-mediated lipid metabolism and mitochondrial dysfunction in human colon epithelial cells.Food Chem Toxicol202642697461PubTator, text miningPubMed
Inflammatory-metabolic coupling in glia: LCN2-PDK axis as molecular mechanism and therapeutic paradigm.Biochem Pharmacol202642665101PubTator, text miningPubMed
Unraveling the association between triclosan and breast cancer: A multidimensional research strategy integrating machine learning, mendelian randomization, and molecular dynamics simulations.Environ Int202642594736PubTator, text miningPubMed
The tire antioxidant derivative 6PPD-quinone exacerbates IBD by targeting NR1H4-mediated lipid metabolism and mitochondrial dysfunction in human colon epithelial cells.Food Chem Toxicol202642521008PubTator, text miningPubMed
The role of reactive oxygen species metabolism-related genes in mediating cisplatin resistance in ovarian clear cell carcinoma.J Pak Med Assoc202642444226PubTator, text miningPubMed
Bulk RNA sequencing identifies biomarkers for mitochondrial and programmed cell death in keloids.Burns202642314404PubTator, text miningPubMed
Circular RNAs in cancer: Its biogenesis, functions, relationships with cancer progression, applications in immunotherapy and biomarker potentials.Cancer Immunol Immunother202641915211PubTator, text miningPubMed
The role of PYY in improving insulin resistance.Front Endocrinol (Lausanne)202641788781PubTator, text miningPubMed
Microglia-Neuron Crosstalk: An Intimate Molecular Conversation in Neurodegeneration.Int J Mol Sci202641752147PubTator, text miningPubMed

1 to 10 of 1,365

See all 1,365 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5164

GET https://conductscience.org/api/genes/v1/5164/patents?page=2