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Gene · 51645

PPIL1: peptidylprolyl isomerase like 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PPIL1: peptidylprolyl isomerase like 1. Genes, record 51645. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51645

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Gene

Symbol
PPIL1
HGNC
Name
peptidylprolyl isomerase like 1
HGNC
NCBI Gene ID
51645
NCBI Gene
HGNC ID
HGNC:9260
HGNC
Ensembl
ENSG00000137168
NCBI Gene
Aliases
CGI-124, CYPL1, PCH14, PPIase, hCyPX
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y3C6Peptidyl-prolyl cis-trans isomerase-like 116628Ensembl, GeneID, HGNC

Source UniProt

Patents197

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457301Q9Y3C6Espacenet
EP 4650780 A22025-11-199357Q9Y3C6Espacenet
EP 4640849 A22025-10-291400Q9Y3C6Espacenet
EP 4641201 A22025-10-299602Q9Y3C6Espacenet
JP 2025519096 A2025-06-241400Q9Y3C6Espacenet
JP 2025517969 A2025-06-129602Q9Y3C6Espacenet
JP 2025517970 A2025-06-129357Q9Y3C6Espacenet
US 11446398 B22022-09-2061828Q9Y3C6Espacenet
JP 2022524081 A2022-04-27164799Q9Y3C6Espacenet
US 11078247 B22021-08-038803Q9Y3C6Espacenet

1 to 10 of 197

See all 197 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants798

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePPIL1 papersNewest fiscal year
P30CA046934University of Colorado Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant32025
P30CA047904Cancer Center Support Grant32025
P30CA054174Mays Cancer Center at UT Health SA32025
P30CA068485Cancer Center Support Grant32025
ZIAHL002066Mechanisms of cardiac ischemia-reperfusion injury and cardioprotection32025
P01CA116087H. pylori-induced Inflammation and Gastric Cancer22025
P20GM103449Vermont Biomedical Research Network-Vermont INBRE22025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202822025
P30DK058404Molecular and Cellular Basis for Digestive Diseases22025

1 to 10 of 798Source NIH's project files

See all 798 nih grants

Papers1,304

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Pin1-cis P-tau Axis: A Key Common Early Pathogenic Driver, Biomarker and Therapeutic Target Across Neurodegenerative, Traumatic, and Vascular Cognitive Disorders.Cells202642782751PubTator, text miningPubMed
Pin1 in cancer: Signaling mechanisms, structural basis and advances in inhibitor development.Eur J Med Chem202642480355PubTator, text miningPubMed
Optimization of the antiviral spectrum of cyclophilin inhibitors targeting respiratory viruses.Antimicrob Agents Chemother202642467054PubTator, text miningPubMed
Peptidyl-prolyl isomerase B suppresses BEFV- and VSV-induced type I interferon responses via degradation of PBLD.Vet Microbiol202642456219PubTator, text miningPubMed
PIN1 inhibits ferroptosis in gastric cancer cells by regulating the CPEB1‑GPX4 pathway.Oncol Rep202642438262PubTator, text miningPubMed
Structure-Based Discovery of (E)- and (Z)-4-Oxobut-2-enoate Derivatives as Novel Covalent Pin1 Inhibitors with Antitumor Activity.J Med Chem202642388100PubTator, text miningPubMed
From Scaffold to Therapy: Benzimidazole Pharmacophore Evolution in Breast Cancer Research.Chem Biodivers202642127228PubTator, text miningPubMed
Systematic Optimization of Proteolysis-Targeting Chimeras for PIN1 Enables Selective Degradation and Antitumor Activity In Vivo.Pharmaceutics202641900774PubTator, text miningPubMed
Causal relationship between genetically predicted Enzyme and Tinnitus risk: a two-sample bi-directional mendelian randomization study.Braz J Otorhinolaryngol202641895103PubTator, text miningPubMed
IgE to cyclophilin Bet v 7 triggers mast cell activation and mediates cross-reactivity with Ara h 18 in children with seasonal allergic rhinitis.Pediatr Allergy Immunol202641781362PubTator, text miningPubMed

1 to 10 of 1,304

See all 1,304 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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