Gene · 5166
PDK4: pyruvate dehydrogenase kinase 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PDK4: pyruvate dehydrogenase kinase 4. Genes, record 5166. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5166
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q16654 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 411 | 8 | Ensembl, GeneID, HGNC |
Source UniProt
Patents44
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 60573 | Q16654 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 12 | Q16654 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 12 | Q16654 | Espacenet |
| US 12006548 B2 | 2024-06-11 | 525 | Q16654 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 70341 | Q16654 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 173312 | Q16654 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 8288 | Q16654 | Espacenet |
| US 10975437 B2 | 2021-04-13 | 525 | Q16654 | Espacenet |
| US 10429378 B2 | 2019-10-01 | 51 | Q16654 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 241008 | Q16654 | Espacenet |
1 to 10 of 44
See all 44 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| SODIUM DICHLOROACETATE | CHEMBL306823 | Pyruvate dehydrogenase kinase inhibitor | INHIBITOR |
Source ChEMBL
Trials1
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted |
|---|---|---|---|
| NCT00004490 | SODIUM DICHLOROACETATE | PHASE3 |
Source ClinicalTrials.gov
NIH grants1,726
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PDK4 papers | Newest fiscal year |
|---|---|---|---|
| P30DK056341 | Washington University Nutrition Obesity Research Center | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 6 | 2025 |
| P30DK072476 | Pennington/Louisiana NORC | 6 | 2025 |
| P30DK048520 | Colorado Nutrition Obesity Research Center | 5 | 2025 |
| P30EY008098 | Core Grant for Vision Research | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30DK020579 | Diabetes Research Center | 4 | 2025 |
| P30DK034989 | Yale Liver Center | 4 | 2025 |
| P30DK056338 | Texas Medical Center Digestive Diseases Center | 4 | 2025 |
1 to 10 of 1,726Source NIH's project files
See all 1,726 nih grantsPapers3,136
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Maternal obesity imprints methylation marks in oocytes to drive intergenerational metabolic dysfunction. | Nat Metab | 2026 | 42827194 | PubTator, text mining | PubMed |
| Correlation analysis of serum PDK4, NLRP3, and PTEN levels in myocardial injury with sepsis. | J Med Biochem | 2026 | 42781365 | PubTator, text mining | PubMed |
| Integrative transcriptomics and human tibial artery validation identify ADAM12, PDK4, and RUNX1 as peripheral artery disease-associated genes enriched in calcified tibial arteries. | JVS Vasc Sci | 2026 | 42733814 | PubTator, text mining | PubMed |
| A novel approach to reverse Warburg metabolism in patients with recurrent glioblastoma: A phase II pharmacodynamic study of dichloroacetate. | Neurooncol Adv | 2026 | 42719375 | PubTator, text mining | PubMed |
| PPARα activation overcomes fibroinflammatory liver microenvironment-associated anti-PD-1 resistance in hepatocellular carcinoma by mediating GSDME-dependent pyroptosis. | Nat Commun | 2026 | 42693091 | PubTator, text mining | PubMed |
| Targeting the PD-L1-induced PDK4/GLS metabolic axis overcomes anti-PD-1 resistance in non-small cell lung cancer. | J Immunother Cancer | 2026 | 42686373 | PubTator, text mining | PubMed |
| miR-130a-3p Exacerbates Sepsis-Induced Cardiac Dysfunction by Promoting Inflammation and Targeting PDK4. | Clin Appl Thromb Hemost | 2026 | 42657943 | PubTator, text mining | PubMed |
| Integrated Multi-Omics Analysis and Experimental Validation Identify Acetylation-Related Genes as Potential Regulators in Osteoarthritis. | Biomedicines | 2026 | 42652188 | PubTator, text mining | PubMed |
| Metabolic control of smooth muscle cell phenotype switching in atherosclerosis. | Sci Adv | 2026 | 42647644 | PubTator, text mining | PubMed |
| CircRNA PVT1 promotes migration, invasion and glucose metabolism of thyroid cancer cells through modulating the miR-195-5p-PDK4 axis. | Cytotechnology | 2026 | 42597312 | PubTator, text mining | PubMed |
1 to 10 of 3,136
See all 3,136 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5166
GET https://conductscience.org/api/genes/v1/5166/patents?page=2