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Gene · 5166

PDK4: pyruvate dehydrogenase kinase 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PDK4: pyruvate dehydrogenase kinase 4. Genes, record 5166. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5166

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Gene

Symbol
PDK4
HGNC
Name
pyruvate dehydrogenase kinase 4
HGNC
NCBI Gene ID
5166
NCBI Gene
HGNC ID
HGNC:8812
HGNC
Ensembl
ENSG00000004799
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16654[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial4118Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1460573Q16654Espacenet
EP 4650780 A22025-11-1912Q16654Espacenet
JP 2025517970 A2025-06-1212Q16654Espacenet
US 12006548 B22024-06-11525Q16654Espacenet
US 11446398 B22022-09-2070341Q16654Espacenet
JP 2022524081 A2022-04-27173312Q16654Espacenet
US 11078247 B22021-08-038288Q16654Espacenet
US 10975437 B22021-04-13525Q16654Espacenet
US 10429378 B22019-10-0151Q16654Espacenet
JP 2019054813 A2019-04-11241008Q16654Espacenet

1 to 10 of 44

See all 44 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
SODIUM DICHLOROACETATECHEMBL306823Pyruvate dehydrogenase kinase inhibitorINHIBITOR

Source ChEMBL

Trials1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first posted
NCT00004490SODIUM DICHLOROACETATEPHASE3

NIH grants1,726

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDK4 papersNewest fiscal year
P30DK056341Washington University Nutrition Obesity Research Center102025
P30CA016672Cancer Center Support Grant82025
P30CA014195Cancer Center Support Grant (CCSG)62025
P30DK072476Pennington/Louisiana NORC62025
P30DK048520Colorado Nutrition Obesity Research Center52025
P30EY008098Core Grant for Vision Research52025
P30CA008748Cancer Center Support Grant42025
P30DK020579Diabetes Research Center42025
P30DK034989Yale Liver Center42025
P30DK056338Texas Medical Center Digestive Diseases Center42025

1 to 10 of 1,726Source NIH's project files

See all 1,726 nih grants

Papers3,136

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Maternal obesity imprints methylation marks in oocytes to drive intergenerational metabolic dysfunction.Nat Metab202642827194PubTator, text miningPubMed
Correlation analysis of serum PDK4, NLRP3, and PTEN levels in myocardial injury with sepsis.J Med Biochem202642781365PubTator, text miningPubMed
Integrative transcriptomics and human tibial artery validation identify ADAM12, PDK4, and RUNX1 as peripheral artery disease-associated genes enriched in calcified tibial arteries.JVS Vasc Sci202642733814PubTator, text miningPubMed
A novel approach to reverse Warburg metabolism in patients with recurrent glioblastoma: A phase II pharmacodynamic study of dichloroacetate.Neurooncol Adv202642719375PubTator, text miningPubMed
PPARα activation overcomes fibroinflammatory liver microenvironment-associated anti-PD-1 resistance in hepatocellular carcinoma by mediating GSDME-dependent pyroptosis.Nat Commun202642693091PubTator, text miningPubMed
Targeting the PD-L1-induced PDK4/GLS metabolic axis overcomes anti-PD-1 resistance in non-small cell lung cancer.J Immunother Cancer202642686373PubTator, text miningPubMed
miR-130a-3p Exacerbates Sepsis-Induced Cardiac Dysfunction by Promoting Inflammation and Targeting PDK4.Clin Appl Thromb Hemost202642657943PubTator, text miningPubMed
Integrated Multi-Omics Analysis and Experimental Validation Identify Acetylation-Related Genes as Potential Regulators in Osteoarthritis.Biomedicines202642652188PubTator, text miningPubMed
Metabolic control of smooth muscle cell phenotype switching in atherosclerosis.Sci Adv202642647644PubTator, text miningPubMed
CircRNA PVT1 promotes migration, invasion and glucose metabolism of thyroid cancer cells through modulating the miR-195-5p-PDK4 axis.Cytotechnology202642597312PubTator, text miningPubMed

1 to 10 of 3,136

See all 3,136 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5166

GET https://conductscience.org/api/genes/v1/5166/patents?page=2