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PDK4: pyruvate dehydrogenase kinase 4
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Gene · 5166

Papers3,136

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

21 to 40 of 3,136

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TitleJournalYearPMIDFound bySource
Mechanisms of vascular calcification: cellular phenotype switching drives matrix remodeling and mineralized microenvironment formation.Front Cardiovasc Med202642395876PubTator, text miningPubMed
Tamarixetin Improves Metabolic Dysfunction by Inhibiting the p300-Mediated Epigenetic Activation of Pyruvate Dehydrogenase Kinase 4.J Med Food202642376872PubTator, text miningPubMed
PDK4-dependent lactate production and lactylation promote renal calcium oxalate crystal-induced EMT and mitochondrial dysfunction via the TGF-β/SMAD3/GPX4 axis.Cell Signal202642364861PubTator, text miningPubMed
[Reshaping glycometabolic reprogramming to suppress M1 macrophage polarization for diabetic wound therapy].Sheng Li Xue Bao202642358142PubTator, text miningPubMed
Integrated Bulk and Single-Cell Transcriptomic Analysis Followed by Clinical Validation Reveal Programmed Cell Death-Related Shared Molecular Signatures in OA and MDD.Int J Mol Sci202642352882PubTator, text miningPubMed
m6A target gene signatures reveal immune-related diagnostic biomarkers in systemic sclerosis-associated pulmonary arterial hypertension.J Thorac Dis202642306654PubTator, text miningPubMed
PDK4 drives time-dependent physical endurance impairment during acute hypoxia by disrupting carbohydrate metabolism.Nutr Metab (Lond)202642304482PubTator, text miningPubMed
Beyond proteostasis: LONP1 as an immunometabolic checkpoint in health and disease.Biochem Pharmacol202642302976PubTator, text miningPubMed
TET3 promotes preeclampsia by regulating PDK4-mediated glucose metabolism reprogramming in trophoblasts.iScience202642291230PubTator, text miningPubMed
MYC_V1-Related Genes Affect Gastric Cancer Proliferation by Regulating Energy Metabolism and Analysis of Therapeutic Targets.Int J Mol Sci202642278393PubTator, text miningPubMed
Aristolochic Acid and Hepatocellular Carcinoma: A Critical Review of Genotoxic and Inflammatory Mechanisms.Int J Mol Sci202642278277PubTator, text miningPubMed
ac4C modification of PDK4 by NAT10 promotes pulmonary fibrosis by reprogramming mitochondrial dynamics in fibroblasts.Free Radic Biol Med202642264200PubTator, text miningPubMed
Metabolic control of smooth muscle cell phenotype switching in atherosclerosis.bioRxiv202642239337PubTator, text miningPubMed
Modulation of intestinal bile acids influences colonic mucosal responses.Sci Rep202642236792PubTator, text miningPubMed
Immunological differences in atopic dermatitis across age groups: insights from single-cell multi-omics.J Transl Med202642231444PubTator, text miningPubMed
Impact of aging on CD146+ mesenchymal stromal cells-mediated regulation of bone marrow CD34+ hematopoietic stem/progenitor cell mobilization.Front Bioeng Biotechnol202642183054PubTator, text miningPubMed
Peroxisome proliferator-activated receptor-α activation attenuates susceptibility to postoperative atrial fibrillation.J Thorac Dis202642182749PubTator, text miningPubMed
Piceatannol-3'-O-β-d-glucopyranoside mitigates myocardial ischemia-reperfusion injury by inhibiting ferroptosis through the regulation of NDUFS1 lactylation via metabolic reprogramming.Redox Biol202642134300PubTator, text miningPubMed
Immune cells with senescence-related transcriptional signatures orchestrate the inflammatory continuum in osteoarthritis synovium: a single-cell and machine learning study.Front Immunol202642079609PubTator, text miningPubMed
Transcriptomic identification of PDK4 as a potential target of leonurine to ox-LDL-induced inflammation and lipid accumulation in THP-1 macrophages.Biochem Biophys Res Commun202642061006PubTator, text miningPubMed

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  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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