Gene · 5167
ENPP1: ectonucleotide pyrophosphatase/phosphodiesterase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ENPP1: ectonucleotide pyrophosphatase/phosphodiesterase 1. Genes, record 5167. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5167
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P22413 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 | 925 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents117
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026083297 A | 2026-05-19 | 1 | P22413 | Espacenet |
| JP 2026015456 A | 2026-01-29 | 1 | P22413 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 44720 | P22413 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 19683 | P22413 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 4087 | P22413 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 25512 | P22413 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1395 | P22413 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1395 | P22413 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 4087 | P22413 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 25512 | P22413 | Espacenet |
1 to 10 of 117
See all 117 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,184
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ENPP1 papers | Newest fiscal year |
|---|---|---|---|
| UL1TR001863 | Yale Clinical and Translational Science Award | 11 | 2025 |
| P30DK036836 | Diabetes Research Center | 10 | 2025 |
| P20GM113134 | COBRE-DIABETES | 9 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
| ZIAHG000215 | Human Biochemical Genetics | 9 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 5 | 2025 |
| P30CA034196 | Cancer Center Support (CORE) Grant | 5 | 2025 |
| R01AR080416 | ENPP1 regulation of mammalian bone mass | 5 | 2025 |
| ZIADE000649 | Skeletal Disorders and Mineral Homeostasis Section | 5 | 2025 |
| P01AI039671 | Costimulatory Mechanisms of Autoimmunity | 4 | 2025 |
1 to 10 of 2,184Source NIH's project files
See all 2,184 nih grantsPapers3,183
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Gene-Based Rare Variant Burden Analyses Across Biobanks Identify Novel High-Risk Genes for Thoracic Aortic Disease. | medRxiv | 2026 | 42818172 | PubTator, text mining | PubMed |
| Reanalysis of genomic data doubles the diagnostic yield for Welsh patients recruited to the UK 100,000 Genomes Project. | Eur J Hum Genet | 2026 | 42806038 | PubTator, text mining | PubMed |
| Retinal Features and Preserved Vision in ENPP1 Deficiency: Long-Term Insights from Multimodal Imaging and Electrophysiology. | Int J Mol Sci | 2026 | 42794828 | PubTator, text mining | PubMed |
| Hyperglycaemia-induced molecular reprogramming of proximal tubular epithelial cells and its contribution to diabetic kidney disease progression-a narrative review. | Front Cell Dev Biol | 2026 | 42787134 | PubTator, text mining | PubMed |
| ADRB3, LEPR, FTO and PPARG variants contribute to obesity-related metabolic syndrome in Brazilian adults: a polygenic risk score approach. | Int J Obes (Lond) | 2026 | 42768086 | PubTator, text mining | PubMed |
| Perinatal Diagnosis of Generalized Arterial Calcification of Infancy: First Genetically Confirmed ENPP1 Case in an Egyptian Fetus. | J Genet Eng Biotechnol | 2026 | 42749424 | PubTator, text mining | PubMed |
| Gap junctions and hemichannels in cancer: A "Wired versus Broadcast" framework for tumor microenvironment routing of cGAMP-STING signals and therapy response. | Transl Oncol | 2026 | 42743660 | PubTator, text mining | PubMed |
| ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance. | Cell Rep | 2026 | 42743059 | PubTator, text mining | PubMed |
| Chronic hypophosphatemia leading to the diagnosis of autosomal recessive hypophosphatemic rickets type 2 caused by a novel pathogenic variant in ENPP1. | Bone | 2026 | 42735739 | PubTator, text mining | PubMed |
| Integrated placental microarray and single-cell transcriptomic analysis prioritizes Trp-Kyn-NAD+ axis-related candidate markers in pre-eclampsia. | Reprod Fertil Dev | 2026 | 42675787 | PubTator, text mining | PubMed |
1 to 10 of 3,183
See all 3,183 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5167
GET https://conductscience.org/api/genes/v1/5167/patents?page=2