ConductScience.org, home

Gene · 5167

ENPP1: ectonucleotide pyrophosphatase/phosphodiesterase 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. ENPP1: ectonucleotide pyrophosphatase/phosphodiesterase 1. Genes, record 5167. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5167

On this page

Gene

Symbol
ENPP1
HGNC
Name
ectonucleotide pyrophosphatase/phosphodiesterase 1
HGNC
NCBI Gene ID
5167
NCBI Gene
HGNC ID
HGNC:3356
HGNC
Ensembl
ENSG00000197594
NCBI Gene
Aliases
ARHR2, COLED, M6S1, NPP1, NPPS, PC-1, PCA1, PDNP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P22413Ectonucleotide pyrophosphatase/phosphodiesterase family member 19257Ensembl, GeneID, HGNC

Source UniProt

Patents117

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026083297 A2026-05-191P22413Espacenet
JP 2026015456 A2026-01-291P22413Espacenet
JP 2026004568 A2026-01-1444720P22413Espacenet
EP 4650780 A22025-11-1919683P22413Espacenet
EP 4640849 A22025-10-294087P22413Espacenet
EP 4641201 A22025-10-2925512P22413Espacenet
JP 2025529142 A2025-09-041395P22413Espacenet
US 12371689 B22025-07-291395P22413Espacenet
JP 2025519096 A2025-06-244087P22413Espacenet
JP 2025517969 A2025-06-1225512P22413Espacenet

1 to 10 of 117

See all 117 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,184

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleENPP1 papersNewest fiscal year
UL1TR001863Yale Clinical and Translational Science Award112025
P30DK036836Diabetes Research Center102025
P20GM113134COBRE-DIABETES92025
P30CA008748Cancer Center Support Grant92025
ZIAHG000215Human Biochemical Genetics92025
P30CA014051Cancer Center Support (Core) Grant52025
P30CA034196Cancer Center Support (CORE) Grant52025
R01AR080416ENPP1 regulation of mammalian bone mass52025
ZIADE000649Skeletal Disorders and Mineral Homeostasis Section52025
P01AI039671Costimulatory Mechanisms of Autoimmunity42025

1 to 10 of 2,184Source NIH's project files

See all 2,184 nih grants

Papers3,183

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Gene-Based Rare Variant Burden Analyses Across Biobanks Identify Novel High-Risk Genes for Thoracic Aortic Disease.medRxiv202642818172PubTator, text miningPubMed
Reanalysis of genomic data doubles the diagnostic yield for Welsh patients recruited to the UK 100,000 Genomes Project.Eur J Hum Genet202642806038PubTator, text miningPubMed
Retinal Features and Preserved Vision in ENPP1 Deficiency: Long-Term Insights from Multimodal Imaging and Electrophysiology.Int J Mol Sci202642794828PubTator, text miningPubMed
Hyperglycaemia-induced molecular reprogramming of proximal tubular epithelial cells and its contribution to diabetic kidney disease progression-a narrative review.Front Cell Dev Biol202642787134PubTator, text miningPubMed
ADRB3, LEPR, FTO and PPARG variants contribute to obesity-related metabolic syndrome in Brazilian adults: a polygenic risk score approach.Int J Obes (Lond)202642768086PubTator, text miningPubMed
Perinatal Diagnosis of Generalized Arterial Calcification of Infancy: First Genetically Confirmed ENPP1 Case in an Egyptian Fetus.J Genet Eng Biotechnol202642749424PubTator, text miningPubMed
Gap junctions and hemichannels in cancer: A "Wired versus Broadcast" framework for tumor microenvironment routing of cGAMP-STING signals and therapy response.Transl Oncol202642743660PubTator, text miningPubMed
ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance.Cell Rep202642743059PubTator, text miningPubMed
Chronic hypophosphatemia leading to the diagnosis of autosomal recessive hypophosphatemic rickets type 2 caused by a novel pathogenic variant in ENPP1.Bone202642735739PubTator, text miningPubMed
Integrated placental microarray and single-cell transcriptomic analysis prioritizes Trp-Kyn-NAD+ axis-related candidate markers in pre-eclampsia.Reprod Fertil Dev202642675787PubTator, text miningPubMed

1 to 10 of 3,183

See all 3,183 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5167

GET https://conductscience.org/api/genes/v1/5167/patents?page=2